Chemical Mutagenesis of Human Interferon-β: Construction, Expression inE. coli, and Biological Activity of Sodium Bisulfite-Induced Mutations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

[2] New M13 vectors for cloning

1983 • 5,402 citations

Translational Initiation in Prokaryotes

1981 • 785 citations

Characterization of translational initiation sites inE. coli

1982 • 673 citations

Antitumor effects of interferon

1978 • 346 citations

A role for mRNA secondary structure in the control of translation initiation

1982 • 344 citations

Cytoplasmic Inclusion Bodies in Escherichia coli Producing Biosynthetic Human Insulin Proteins

1982 • 308 citations

The human interferons—From protein purification and sequence to cloning and expression in bacteria: Before, between, and beyond

1983 • 236 citations

Secondary structure of mRNA and efficiency of translation initiation

1980 • 210 citations

Isolation and Purification of Protein Granules from Escherichia coli Cells Overproducing Bovine Growth Hormone

1985 • 201 citations

Structural relationship of human interferon alpha genes and pseudogenes

1985 • 195 citations

Target cell specificity of two species of human interferon-alpha produced in Escherichia coli and of hybrid molecules derived from them.

1981 • 190 citations

The filamentous phage (Ff) as vectors for recombinant DNA— a review

1982 • 188 citations

Structure and expression of a cloned cDNA for mouse interferon-beta.

1983 • 157 citations

Structure and expression of cloned murine IFN-α genes

1983 • 154 citations

Escherichia coli ribonuclease III cleavage sites

1982 • 149 citations

Antiviral activities of hybrids of two major human leukocyte interferons

1981 • 148 citations

[50] Proteases in Escherichia coli

1981 • 125 citations

Inducible high level synthesis of mature human fibroblast interferon inEscherichia coli

1983 • 101 citations

The influence of mRNA primary and secondary structure on human IFN-γ gene expression inE. coli

1984 • 97 citations

Organization, structure and expression of murine interferon alpha genes

1985 • 97 citations

Characterization of a mouse interferon gene locus I. Isolation of a cluster of four α-interferon genes

1985 • 82 citations

Processing of procaryotic ribonucleic acid.

1981 • 78 citations

Prediction of the secondary and tertiary structures of interferon from four homologous amino acid sequences

1982 • 77 citations

[31] Directed mutagenesis with sodium bisulfite

1983 • 77 citations

Effects of recombinant and hybrid recombinant human leukocyte interferons on cytotoxic activity of natural killer cells.

1983 • 76 citations

The Structure and Bacterial Expression of Three Distinct Bovine Interferon-β Genes

1984 • 57 citations

Isolation and Bacterial Expression of a Murine Alpha Leukocyte Interferon Gene

1984 • 51 citations

Is sequence conservation in interferons due to selection for functional proteins?

1985 • 50 citations

Antiviral and protein-inducing activities of recombinant human leukocyte interferons and their hybrids

1984 • 45 citations

A single amino acid change in IFN-β1 abolishes its antiviral activity

1981 • 43 citations

Structure and expression inEscherichia coilof a cloned rat interferon-α gene

1984 • 41 citations

Antiviral Activities of Cloned Human Leukocyte Interferons against Herpes Simplex Virus Type 2 Infections of Mice

1983 • 24 citations

Biological Properties of Human Interferon Beta 1 Synthesized in Recombinant Bacteria

1983 • 19 citations

Novel Modified β-Interferons: Gene Cloning, Expression, and Biological Activity in Bacterial Extracts

1986 • 12 citations