Functional significance of amino acid residues within conserved hydrophilic regions in human interferons-α

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

INTERFERONS AND THEIR ACTIONS

1987 • 1,838 citations

Functional messenger RNAs are produced by SP6in vitrotranscription of cloned cDNAs

1984 • 1,533 citations

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA

1978 • 1,055 citations

Transcription and Translation — A Practical Approach

1985 • 811 citations

The biology of the interferon system 1984

1985 • 413 citations

The Interferon Genes

1986 • 304 citations

Specific molecular activities of recombinant and hybrid leukocyte interferons.

1982 • 298 citations

A family of structural genes for human lymphoblastoid (leukocyte-type) interferon

1980 • 253 citations

Human leukocyte interferon: production, purification to homogeneity, and initial characterization.

1979 • 233 citations

Target cell specificity of two species of human interferon-alpha produced in Escherichia coli and of hybrid molecules derived from them.

1981 • 190 citations

Antiviral activities of hybrids of two major human leukocyte interferons

1981 • 148 citations

Human leukocyte interferon subtypes have different antiproliferative and antiviral activities on human cells

1983 • 119 citations

Various human interferon a subclasses cross-react with common receptors: Their binding affinities correlate with their specific biological activities

1984 • 113 citations

Prediction of the secondary and tertiary structures of interferon from four homologous amino acid sequences

1982 • 77 citations

Simplified DNA manupulations based on in vitro mutagenesis

1985 • 53 citations

Is sequence conservation in interferons due to selection for functional proteins?

1985 • 50 citations

Functionally important conserved amino-acids in interferon-α2 identified with analogues produced from synthetic genes

1986 • 42 citations

Cell Surface Receptor-mediated Internalization of Interferon: Its Relation to the Antiviral Activity of Interferon

1983 • 41 citations

Receptor dynamics of closely related ligands: ‘fast’ and ‘slow’ interferons.

1985 • 31 citations

Production of a monoclonal antibody to human interferon-α (IFN-α) and its use to identify IFN-α-producing cells in virus infection in vivo

1986 • 26 citations

Efficient in vitro expression of interferon α analogs using SP6 polymerase and rabbit reticulocyte lysate

1988 • 26 citations

Gene expression in Acetabularia: I. Calibration of wheat germ cell-free translation system proteins as internal references for two-dimensional electrophoresis

1982 • 22 citations

Single amino acid substitutions at conserved residues of human interferon-alpha can effect antiviral specific activity.

1985 • 15 citations

Interferon analogues from synthetic genes: an approach to protein structure-activity studies.

1986 • 14 citations

Conserved amino acid residues arginine 33 and tyrosine 123 are critical for the antiviral activity of murine interferon-α1

1988 • 14 citations

SHORT COMMUNICATION: Amino Acid Substitutions Which Alter the Antiviral Activity of Human Interferon-α₁on Mouse Cells

1988 • 10 citations

Construction of expression vectors for the production of interferons in yeast.

1987 • 8 citations

Nucleotide sequence and expression in E. coli of a human interferon-alpha gene selected from a genomic library using synthetic oligonucleotides.

1984 • 4 citations