Efficient mapping and characterization of a T cell epitope by the simultaneous synthesis of multiple peptides

General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

1985 • 1,650 citations

Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.

1984 • 1,467 citations

Binding of immunogenic peptides to Ia histocompatibility molecules

1985 • 1,209 citations

Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis

1988 • 838 citations

The Relation Between Major Histocompatibility Complex (MHC) Restriction and the Capacity of Ia to Bind Immunogenic Peptides

1987 • 696 citations

A sequence pattern common to T cell epitopes.

1988 • 623 citations

A priori delineation of a peptide which mimics a discontinuous antigenic determinant

1986 • 499 citations

Prediction of immunodominant helper T cell antigenic sites from the primary sequence.

1987 • 483 citations

Isolation and characterization of antigen-la complexes involved in T cell recognition

1986 • 470 citations

Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans.

1985 • 463 citations

Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells

1987 • 367 citations

[15] Cleavage at aspartylprolyl bonds

1977 • 319 citations

Identification of the T-cell and Ia contact residues of a T-cell antigenic epitope

1987 • 297 citations

Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II.

1984 • 296 citations

Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein.

1985 • 289 citations

Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: process of selection of lines and characterization of the cells.

1982 • 261 citations

Characterization, sequence determination, and immunogenicity of a 64-kilodalton protein of Mycobacterium bovis BCG expressed in escherichia coli K-12

1987 • 252 citations

Cognitive features of continuous antigenic determinants

1988 • 162 citations

T lymphocyte clones illuminate pathogenesis and affect therapy of experimental arthritis

1985 • 155 citations

Antigen processing at the molecular level

1987 • 137 citations

Use of recombinant antigens expressed in Escherichia coli K-12 to map B-cell and T-cell epitopes on the immunodominant 65-kilodalton protein of Mycobacterium bovis BCG

1988 • 101 citations

Hydrophobic strip-of-helix algorithm for selection of T cell-presented peptides☆

1987 • 91 citations

Mutations of class II MHC molecules

1987 • 85 citations

Antigenicity and Immunogenicity of Synthetic Peptides of Foot-and-Mouth Disease Virus

1987 • 60 citations

Epitope mapping of the outer structural protein VP1 of three different serotypes of foot-and-mouth disease virus

1986 • 35 citations