A comparative assessment of the efficacy and side-effect liability of neuroprotective compounds in experimental stroke

Pathobiology of ischaemic stroke: an integrated view

1999 • 3,776 citations

Ebselen in Acute Ischemic Stroke

1998 • 597 citations

Clinical trials with neuroprotective drugs in acute ischaemic stroke: are we doing the right thing?

1999 • 375 citations

Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: a randomised controlled trial

2000 • 302 citations

Ischemic brain edema following occlusion of the middle cerebral artery in the rat. I: The time courses of the brain water, sodium and potassium contents and blood-brain barrier permeability to 125I-albumin.

1985 • 300 citations

Mechanisms of Ionotropic Glutamate Receptor-Mediated Excitotoxicity in Isolated Spinal Cord White Matter

2000 • 292 citations

Neuroprotective Effects of a Novel Nitrone, NXY-059, after Transient Focal Cerebral Ischemia in the Rat

1999 • 242 citations

Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.

1990 • 198 citations

Cerestat and other NMDA antagonists in ischemic stroke

1997 • 185 citations

Lacunar infarcts. Pathogenesis and validity of the clinical syndromes.

1991 • 176 citations

Clomethiazole Acute Stroke Study (CLASS)

1999 • 175 citations

Continuing Ischemic Damage After Acute Middle Cerebral Artery Infarction in Humans Demonstrated by Short-Echo Proton Spectroscopy

1995 • 153 citations

Massive Persistent Release of Excitatory Amino Acids Following Human Occlusive Stroke

1995 • 151 citations

The pharmacotherapy of focal cortical ischaemia in the mouse

1990 • 151 citations

Factors determining the therapeutic window for stroke

1998 • 145 citations

Drug development for stroke: importance of protecting cerebral white matter

1999 • 128 citations

Neuroprotection for Acute Stroke

1999 • 104 citations

Tolerability and Pharmacokinetics of the Nitrone NXY-059 in Patients With Acute Stroke

2001 • 98 citations

Neuroprotective Therapy

1998 • 94 citations

Many agents that antagonize the NMDA receptor-channel complex in vivo also cause disturbances of motor coordination.

1994 • 92 citations

A mouse model of focal cerebral ischemia for screening neuroprotective drug effects

1992 • 91 citations

The Glycine Antagonist GV150526 Protects Somatosensory Evoked Potentials and Reduces the Infarct Area in the MCAo Model of Focal Ischemia in the Rat

1997 • 88 citations

Chapter 13 Nitrone-Based Free Radical Traps as Neuroprotective Agents in Cerebral Ischaemia and Other Pathologies

1996 • 85 citations

Temporary middle cerebral artery occlusion in the rat: consistent protocol for a model of stroke and reperfusion

2000 • 74 citations

The Current Status of Neuronal Protective Therapy: Why Have All Neuronal Protective Drugs Worked in Animals but None So Far in Stroke Patients?

1994 • 70 citations

Mechanisms of ischaemic damage to central white matter axons: a quantitative histological analysis using rat optic nerve

1999 • 68 citations

Does neuroprotection improve stroke outcome?

1998 • 68 citations

Improved Therapeutic Window for Treatment of Histotoxic Hypoxia with a Free Radical Spin Trap

1995 • 60 citations

Clomethiazole (Zendra®) in Acute Ischemic Stroke Basic Pharmacology and Biochemistry and Clinical Efficacy

1998 • 59 citations

Excitatory amino acids : clinical results with antagonists

1997 • 57 citations

Safety and Tolerability of GV150526 (a Glycine Site Antagonist at the N -Methyl- <scp>d</scp> -Aspartate Receptor) in Patients With Acute Stroke

1999 • 56 citations

Remacemide Hydrochloride

1999 • 48 citations

Excitatory amino acids—Clinical results with antagonists

1997 • 48 citations

Amino acid neurotransmission

1998 • 35 citations

Clinical trial update: neuroprotection against acute ischaemic stroke

1999 • 28 citations

Sipatrigine (BW 619C89) is a Neuroprotective Agent and a Sodium Channel and Calcium Channel Inhibitor

2000 • 27 citations

N-methyl-D-aspartate antagonists for stroke and head trauma

1997 • 26 citations

Neuroprotection of Acute Ischemic Stroke: Where are We?

1999 • 25 citations

Focal ischemia enhances the adverse effect potential of N-methyl-d-aspartate receptor antagonists in rats

1998 • 22 citations

Chapter 8 Development of the NMDA Ion-Channel Blocker, Aptiganel Hydrochloride, as a Neuroprotective Agent for Acute CNS Injury

1996 • 16 citations

The Low‐Affinity, Use‐Dependent NMDA Receptor Antagonist AR‐R 15896AR: An Update of Progress in Stroke

1999 • 16 citations

Preclinical and Clinical Aspects of Remacemide Hydrochloride

1997 • 13 citations

Ifenprodil and Eliprodil

1997 • 13 citations

Ligands of the NMDA receptor-associated glycine recognition site and motor behavior

1998 • 12 citations

The NBQX Story

1997 • 10 citations