The Low‐Affinity, Use‐Dependent NMDA Receptor Antagonist AR‐R 15896AR: An Update of Progress in Stroke

Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines

1993 • 318 citations

The problem of assessing effective neuroprotection in experimental cerebral ischemia

1998 • 279 citations

Specific Domains of β-Amyloid from Alzheimer Plaque Elicit Neuron Killing in Human Microglia

1996 • 268 citations

Trapping Channel Block of NMDA-Activated Responses By Amantadine and Memantine

1997 • 237 citations

A new model of temporary focal neocortical ischemia in the rat.

1992 • 225 citations

Regional Variations in the Pharmacology of NMDA Receptor Channel Blockers: Implications for Therapeutic Potential

1995 • 137 citations

Calpain Activation Contributes to Dendritic Remodeling after Brief Excitotoxic InjuryIn Vitro

1997 • 136 citations

Selective Vulnerability of the Brain: New Insights into the Pathophysiology of Stroke

1989 • 126 citations

Antiepileptic Drug Actions

1989 • 109 citations

Differences in degree of trapping of low-affinity uncompetitive N-methyl-D-aspartic acid receptor antagonists with similar kinetics of block.

1999 • 92 citations

NR1 and NR2 subunit contributions to N-methyl-D-aspartate receptor channel blocker pharmacology.

1997 • 87 citations

Reorganization of the Cytoskeleton in Rat Neurons Following Stimulation With Excitatory Amino Acids In Vitro

1991 • 74 citations

Dizocilpine-like Discriminative Stimulus Effects of Low-affinity Uncompetitive NMDA Antagonists

1996 • 59 citations

Block of the N-methyl-D-aspartate receptor by remacemide and its des-glycine metabolite.

1996 • 51 citations

Clinical pharmacokinetics of escalating i.v. doses of dexanabinol (HU-211), a neuroprotectant agent, in normal volunteers.

1997 • 43 citations

-(S)-Alpha-phenyl-2-pyridine-ethanamine Dihydrochloride-, a low affinity uncompetitive N-methyl-D-aspartic acid antagonist, is effective in rodent models of global and focal ischemia.

1997 • 36 citations

N‐Methyl‐<scp>d</scp>‐Aspartate‐ or Glutamate‐Mediated Toxicity in Cultured Rat Cortical Neurons Is Antagonized by FPL 15896AR

1995 • 34 citations

Alteration in NMDA receptor subunit mRNA expression in vulnerable and resistant regions of in vitro ischemic rat hippocampal slices

1997 • 32 citations

Neuroprotective Properties of the Uncompetitive NMDA Receptor Antagonist Remacemide Hydrochloride

1995 • 30 citations

ARL-15896, a NovelN-Methyl-D-aspartate Receptor Ion Channel Antagonist: Neuroprotection against Mitochondrial Metabolic Toxicity and Regional Pharmacology

1996 • 23 citations

Effects of anticonvulsants in a novel operant learning paradigm in rats: Comparison of remacemide hydrochloride and FPL 15896AR to other anticonvulsant agents

1995 • 22 citations

Study of potency, kinetics of block and toxicity of NMDA receptor antagonists using fura-2

1996 • 22 citations

Antagonism of N-methyl-D-aspartate-evoked currents in rat cortical cultures by ARL 15896AR.

1997 • 19 citations

Low‐Affinity NMDA Receptor Antagonists

1997 • 16 citations

Lippincott‐Raven Publishers, Philadelphia © International League Against Epilepsy Remacemide Hydrochloride and ARL 15896AR Lack Abuse Potential: Additional Differences from Other Uncompetitive NMDA Antagonists

1996 • 15 citations

[S]-AR-R 15896AR-A novel anticonvulsant: acute safety, pharmacokinetic and pharmacodynamic properties.

1999 • 15 citations

The anticonvulsant (±)-5-aminocarbonyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (ADCI) selectively blocks NMDA-activated current in cultured rat hippocampal neurones: Kinetic analysis and comparison with dizocilpine

1992 • 14 citations

Preclinical and Clinical Aspects of Remacemide Hydrochloride

1997 • 13 citations

Neuroprotective actions of 2-amino-N-(1,2-diphenylethyl)-acetamide hydrochloride (FPL 13950) in animal models of hypoxia and global ischemia.

1995 • 13 citations

σ receptor-mediated emetic response in pigeons: agonists, antagonists and modifiers

1993 • 13 citations

Cerebroprotective and anticonvulsant action of competitive and non-competitive NMDA antagonists

1990 • 10 citations

AR-R15896AR blocks the early NMDA-induced loss of MAP2 in primary cortical cultures

1999 • 9 citations

Lack of evidence for direct involvement of NMDA receptors or polyamines in blood–brain barrier injury after cerebral ischemia in rats

1998 • 9 citations

Therapeutic potential of PCP receptor ligands

1994 • 5 citations

Correlates of bupropion HCl (Wellbutrin) serum levels with age, weight, sex and cigarette smoking

1992 • 4 citations