Sipatrigine (BW 619C89) is a Neuroprotective Agent and a Sodium Channel and Calcium Channel Inhibitor

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Cerebroprotective effect of BW619C89 after focal or global cerebral ischaemia in the rat

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Contrasting Ca²⁺ channel subtypes at cell bodies and synaptic terminals of rat anterioventral cochlear bushy neurones

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Long-term beneficial effects of BW619C89 on neurological deficit, cognitive deficit and brain damage after middle cerebral artery occlusion in the rat

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State-dependent inhibition of Na+ currents by the neuroprotective agent 619C89 in rat hippocampal neurons and in a mammalian cell line expressing rat brain type IIA Na+ channels

1996 • 44 citations

Chapter 7 NMDA Antagonists: Their Role in Neuroprotection

1996 • 44 citations

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Effects of Ca2+ and Na+ channel inhibitors in vitro and in global cerebral ischaemia in vivo

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Chapter 5 Calcium Antagonists: Their Role in Neuroprotection

1996 • 33 citations

A use-dependent sodium channel antagonist, 619C89, in reduction of ischemic brain damage and glutamate release after acute subdural hematoma in the rat

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Neuroprotective Use‐Dependent Blockers of Na⁺ and Ca²⁺ Channels Controlling Presynaptic Release of Glutamate^a

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Neuroprotective Agents and Cerebral Ischaemia

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Chapter 6 Sodium and Potassium Channel Modulators: Their Role in Neuroprotection

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Inhibition of recombinant low-voltage-activated Ca2+ channels by the neuroprotective agent BW619C89 (Sipatrigine)

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Neuroprotective effects of the glutamate release inhibitor 619C89 in temporary middle cerebral artery occlusion

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Consensus Proposal for 5-HT3 Antagonists in the Prevention of Acute Emesis Related to Highly Emetogenic Chemotherapy

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A comparison of the effects of a sodium channel blocker and an NMDA antagonist upon extracellular glutamate in rat focal cerebral ischemia

1995 • 20 citations

On the inhibition of voltage activated calcium currents in rat cortical neurones by the neuroprotective agent 619C89

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A Randomized, Double‐Blind, Placebo‐Controlled Ascending Dose Tolerance Study of 619C89 in Acute Stroke

1995 • 19 citations

Inhibition of human N-type voltage-gated Ca2+ channels by the neuroprotective agent BW619C89

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The neuropathology of vigabatrin.

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Parallel dose–response studies of the voltage-dependent Na+ channel antagonist BW619C89, and the voltage-dependent Ca2+ channel antagonist nimodipine, in rat transient focal cerebral ischaemia

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σ receptor-mediated emetic response in pigeons: agonists, antagonists and modifiers

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Electrophysiology of Sipatrigine: A Lamotrigine Derivative Exhibiting Neuroprotective Effects

2000 • 11 citations

Pharmacokinetics of 619C89, a novel neuronal sodium channel inhibitor, in acute stroke patients after loading and discrete maintenance infusions

1996 • 11 citations

[Physiological function of sigma receptors: central pharmacological effects of sigma ligands].

1994 • 9 citations

Evaluation of the Novel Neuroprotective Agent BW619C89 in the Middle Cerebral Artery Occlusion Model of Focal Ischemia in the Spontaneously Hypertensive Rat and Normotensive Fischer 344 Rat

1995 • 8 citations

About the antiemetic effectivity of granisetron in chemotherapy-induced acute emesis: a comparison of results with intravenous and oral dosing.

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THE NMDA RECEPTOR-ION CHANNEL - ITS IMPORTANCE TO INVIVO ISCHEMIC-INJURY TO SELECTIVELY VULNERABLE NEURONS

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MOLECULAR MODE OF ACTION OF THE NEUROPROTECTIVE AGENT BW619C89

1994 • 5 citations

The neuroprotective agent BW619C89 inhibits neuronal excitability and synaptic transmission in rat corticostriatal slices

1999 • 2 citations

Deleted Work

1955 • 0 citations