Folate and colonic carcinogenesis: searching for a mechanistic understanding

CpG Islands in vertebrate genomes

1987 • 3,315 citations

Biology of Natural Killer Cells

1989 • 2,970 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

Methionine metabolism in mammals

1990 • 1,463 citations

Hypomethylation of DNA from Benign and Malignant Human Colon Neoplasms

1985 • 844 citations

Relaxation of imprinted genes in human cancer

1993 • 792 citations

Folate, Methionine, and Alcohol Intake and Risk of Colorectal Adenoma

1993 • 712 citations

Constitutive Fragile Sites and Cancer

1984 • 693 citations

DNA methylation and gene expression

1991 • 685 citations

Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs

1989 • 655 citations

Hypomethylation of ras oncogenes in primary human cancers

1983 • 507 citations

Reduced genomic 5-methylcytosine content in human colonic neoplasia.

1988 • 491 citations

Methionine metabolism in mammals. Distribution of homocysteine between competing pathways.

1984 • 414 citations

Genetic alterations in the adenoma–carcinoma sequence

1992 • 381 citations

Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA.

1983 • 361 citations

Effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis

1989 • 325 citations

A comparison of cancer risk in crohn's disease and ulcerative colitis

1981 • 304 citations

Methylation and Imprinting: from Host Defense to Gene Regulation?

1993 • 299 citations

The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens

1984 • 296 citations

Folate Intake and Carcinogenesis of the Colon and Rectum

1991 • 293 citations

DNA methylation and gene expression.

1991 • 291 citations

DNA Methylation in Folate Deficiency: Use of CpG Methylase

1993 • 286 citations

Nutritional factors in colorectal cancer risk: A case‐control study in majorca

1991 • 281 citations

Possible involvement of protein kinase C and calcium ion in growth factor-induced expression of c-myc oncogene in Swiss 3T3 fibroblasts.

1986 • 241 citations

Folate deficiency enhances the development of colonic neoplasia in dimethylhydrazine-treated rats.

1992 • 225 citations

Improvement in cervical dysplasia associated with folic acid therapy in users of oral contraceptives

1982 • 215 citations

Folate Deficiency and Cervical Dysplasia

1992 • 205 citations

Impaired Folic Acid Absorption in Inflammatory Bowel Disease: Effects of Salicylazosulfapyridine (Azulfidine)

1973 • 201 citations

Rapid appearance of hypomethylated DNA in livers of rats fed cancer-promoting, methyl-deficient diets.

1989 • 190 citations

Labile Methyl Groups and the Promotion of Cancer

1986 • 169 citations

Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer.

1992 • 165 citations

Improvement in bronchial squamous metaplasia in smokers treated with folate and vitamin B12. Report of a preliminary randomized, double-blind intervention trial

1988 • 154 citations

Integration sites of human papillomavirus 18 DNA sequences on HeLa cell chromosomes

1987 • 152 citations

Red blood cell folate is associated with the development of dysplasia and cancer in ulcerative colitis

1993 • 150 citations

Folate Deficiency in Rats Fed Diets Containing Free Amino Acids or Intact Proteins

1988 • 142 citations

Inhibition of Folate Enzymes by Sulfasalazine

1978 • 137 citations

Oral folic acid supplementation for cervical dysplasia: A clinical intervention trial

1992 • 137 citations

Bacterially Synthesized Folate in Rat Large Intestine is Incorporated into Host Tissue Folyl Polyglutamates

1991 • 127 citations

Altered levels of protein kinase C and Ca2+-dependent protein kinases in human colon carcinomas.

1987 • 126 citations

Alterations in expression and methylation of specific gene in livers of rats fed a cancer promoting methyl-deficient diet

1991 • 125 citations

Association of Marginal Folate Depletion With Increased Human Chromosomal Damage In Vivo: Demonstration by Analysis of Micronucleated Erythrocytes

1988 • 121 citations

Improvement in Bronchial Squamous Metaplasia in Smokers Treated With Folate and Vitamin B12

1988 • 121 citations

Folate status and the immune system.

1991 • 120 citations

A mutant protein kinase C that can transform fibroblasts

1989 • 119 citations

Sulfasalazine Inhibits the Absorption of Folates in Ulcerative Colitis

1981 • 117 citations

Liver cell proliferation and incidence of hepatocellular carcinomas in rats fed consecutively a choline-devoid and a choline-supplemented diet

1988 • 92 citations

Accumulation of 1,2-sn-diradylglycerol with increased membrane-associated protein kinase C may be the mechanism for spontaneous hepatocarcinogenesis in choline-deficient rats.

1993 • 91 citations

Molecular genetics of colorectal carcinoma

1992 • 85 citations

Rodent models for carcinoma of the colon

1985 • 81 citations

Folie acid deficiency and methyl group metabolism in rat brain: Effects of l-dopa

1974 • 77 citations

1,2-Dimethylhydrazine-induced alterations in protein kinase C activity in the rat preneoplastic colon.

1990 • 60 citations

Hepatic Content of S-Adenosylmethionine, S-Adenosylhomocysteine and Glutathione in Rats Receiving Treatments Modulating Methyl Donor Availability

1989 • 47 citations

Protein kinase C activity as marker for colorectal cancer

1991 • 45 citations

Amplification and elevated expression of c-myc in a chemically induced mouse colon tumor.

1985 • 32 citations

Effects of folate in culture medium on common fragile sites in lymphocyte chromosomes from normal and leukemic children

1988 • 23 citations

Effects of dietary choline deficiency on the mutagenic activation of chemical carcinogens by rat liver fractions

1983 • 8 citations

Activated K‐ras in Tumorigenic and Non‐tumorigenic Cell Variants from a Rat Colon Adenocarcinoma, Induced by Dimethylhydrazine

1988 • 5 citations