Molecular genetics of colorectal carcinoma

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

Hereditary Colorectal Cancer

2003 • 2,142 citations

The evolution of cancer of the colon and rectum

1975 • 2,120 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Tumor Suppressor Genes

1991 • 1,784 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

Allelotype of Colorectal Carcinomas

1989 • 1,333 citations

p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.

1990 • 1,080 citations

Hypomethylation of DNA from Benign and Malignant Human Colon Neoplasms

1985 • 844 citations

Identification of deletion mutations and three new genes at the familial polyposis locus

1991 • 769 citations

Identification of a Gene Located at Chromosome 5q21 that Is Mutated in Colorectal Cancers

1991 • 758 citations

Clonal Analysis of Human Colorectal Tumors

1987 • 638 citations

Cancer statistics, 1991

1991 • 625 citations

Reduced genomic 5-methylcytosine content in human colonic neoplasia.

1988 • 491 citations

Common Inheritance of Susceptibility to Colonic Adenomatous Polyps and Associated Colorectal Cancers

1988 • 472 citations

Gardner syndrome in a man with an interstitial deletion of 5q

1986 • 458 citations

Allelic Loss in Colorectal Carcinoma

1989 • 338 citations

High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer.

1991 • 311 citations

Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis.

1990 • 280 citations

Clinical and pathological associations with allelic loss in colorectal carcinoma [corrected]

1989 • 273 citations

pp60c-src activation in human colon carcinoma.

1989 • 267 citations

Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens.

1991 • 262 citations

Genetic Analysis of an Inherited Predisposition to Colon Cancer in a Family with a Variable Number of Adenomatous Polyps

1990 • 254 citations

Risk of hepatoblastoma in familial adenomatous polyposis

1991 • 242 citations

Screening guidelines and premorbid diagnosis of familial adenomatous polyposis using linkage

1991 • 220 citations

Abnormal patterns of DNA methylation in human neoplasia: potential consequences for tumor progression.

1991 • 207 citations

Familial Polyposis Coli

1976 • 187 citations

Genetic changes and histopathological types in colorectal tumors from patients with familial adenomatous polyposis.

1990 • 179 citations

Inhibition of urokinase-type plasminogen activator by antibodies: the effect on dissemination of a human tumor in the nude mouse.

1991 • 179 citations

The biochemistry of ras p21

1991 • 176 citations

Loss of heterozygosity of p53 gene and p53 protein expression in human colorectal carcinomas.

1991 • 159 citations

From gene to carcinogen: a rapidly evolving field in molecular epidemiology.

1991 • 146 citations

Human colorectal cancer: high frequency of deletions at chromosome 1p35.

1990 • 140 citations

Association of nm23-H1 allelic deletions with distant metastases in colorectal carcinoma

1991 • 135 citations

Isoprenoid modification and plasma membrane association: critical factors for ras oncogenicity.

1991 • 126 citations

The relationship of DNA aneuploidy to molecular genetic alterations in colorectal carcinoma

1992 • 120 citations

Correlations between rectal mucosa cell proliferation and the clinical and pathological features of nonfamilial neoplasia of the large intestine.

1991 • 114 citations

Hereditary non-polyposis colorectal cancer

1991 • 113 citations

Hereditary Colorectal Cancer

1990 • 102 citations

How prevalent is cancer family syndrome?

1991 • 81 citations

Familial Adenomatous Polyposis

1989 • 79 citations

7th Jan Waldenström Lecture. The Biology of Human Cancer Metastasis

1991 • 78 citations

Abnormal methylation of the calcitonin gene in human colonic neoplasms.

1989 • 75 citations

The biology of human cancer metastasis

1991 • 73 citations

Expression of c-myc and other cell cycle-dependent genes in human colon neoplasia.

1985 • 54 citations

Frequency of hereditary nonpolyposis colorectal cancer in southern Alberta

1991 • 48 citations

Variable gastrointestinal and urologic cancers in a lynch syndrome II kindred

1991 • 22 citations

Geographic Epidemiology of Colorectal Cancer: The Role of Dietary Fat

1989 • 15 citations

Correlation between bromodeoxyuridine labelling and ornithine decarboxylase levels in normal rectal mucosa of patients with colorectal adenoma

1991 • 11 citations

Linkage analysis in adenomatous polyposis coli: the use of four closely linked DNA probes in 20 UK families.

1991 • 11 citations