The human heart endothelin system: ET-1 synthesis, storage, release and effect

A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

1998 • 2,570 citations

Polar secretion of endothelin-1 by cultured endothelial cells.

1992 • 650 citations

Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice

1998 • 643 citations

Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy

1990 • 641 citations

Inhibition of myocardial endothelin pathway improves long-term survival in heart failure

1996 • 630 citations

Atrial fibrillation after coronary artery bypass grafting is associated with sympathetic activation

1995 • 372 citations

Role of Endogenous Endothelin in Chronic Heart Failure

1997 • 367 citations

Prognostic impact of big endothelin-1 plasma concentrations compared with invasive hemodynamic evaluation in severe heart failure

1996 • 349 citations

Stimulation of the p38 Mitogen-activated Protein Kinase Pathway in Neonatal Rat Ventricular Myocytes by the G Protein–coupled Receptor Agonists, Endothelin-1 and Phenylephrine: A Role in Cardiac Myocyte Hypertrophy?

1998 • 313 citations

Short-Term Oral Endothelin-Receptor Antagonist Therapy in Conventionally Treated Patients With Symptomatic Severe Chronic Heart Failure

1998 • 292 citations

Characterization and localization of endothelin receptor subtypes in the human atrioventricular conducting system and myocardium.

1993 • 262 citations

Transgenic Overexpression of Constitutively Active Protein Kinase C ε Causes Concentric Cardiac Hypertrophy

2000 • 240 citations

Signaling in Myocardial Hypertrophy

1999 • 199 citations

Handbook of Microscopic Anatomy

1987 • 195 citations

Expression of Endothelin-1, Endothelin-Converting Enzyme, and Endothelin Receptors in Chronic Heart Failure

1999 • 190 citations

Autoradiographical Localization of Binding Sites for Porcine [125I]Endothelin-1 in Humans, Pigs, and Rats

1989 • 179 citations

Functional Effects of Endothelin and Regulation of Endothelin Receptors in Isolated Human Nonfailing and Failing Myocardium

1999 • 173 citations

Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import.

1996 • 173 citations

Ca2+/Calmodulin-dependent Kinase II and Calcineurin Play Critical Roles in Endothelin-1-induced Cardiomyocyte Hypertrophy

2000 • 172 citations

Systemic Blockade of the Endothelin-B Receptor Increases Peripheral Vascular Resistance in Healthy Men

1999 • 153 citations

Activated Protein Kinase C Isoforms Target to Cardiomyocyte Caveolae

1999 • 148 citations

Endothelin Receptors in the Failing and Nonfailing Human Heart

1998 • 140 citations

Activation of β ₂ -Adrenergic Receptors Hastens Relaxation and Mediates Phosphorylation of Phospholamban, Troponin I, and C-Protein in Ventricular Myocardium From Patients With Terminal Heart Failure

1999 • 135 citations

Cardiac Growth Factors in Human Hypertrophy

1999 • 128 citations

Prevention of Cardiac Hypertrophy by Calcineurin Inhibition

1999 • 126 citations

Paracrine effects of endocardial endothelial cells on myocyte contraction mediated via endothelin

1993 • 125 citations

Contrasting Inotropic Effects of Endogenous Endothelin in the Normal and Failing Human Heart

2000 • 123 citations

Acute hemodynamic and neurohumoral effects of selective ETA receptor blockade in patients with congestive heart failure

2000 • 122 citations

Secretory pathways in endothelin synthesis

1999 • 121 citations

Comparison of Plasma Neurohormones in Congestive Heart Failure Patients With Atrial Fibrillation Versus Patients With Sinus Rhythm

1998 • 110 citations

Human Endothelial Cell Storage Granules

1998 • 99 citations

Selective Upregulation of Cardiac Endothelin System in Patients With Ischemic but Not Idiopathic Dilated Cardiomyopathy

2000 • 90 citations

Protein kinase C isoenzymes in rat and human cardiovascular tissues

1997 • 75 citations

Angiotensin converting enzyme inhibition modulates endogenous endothelin in chronic canine thoracic inferior vena caval constriction.

1996 • 68 citations

Endothelin-1 and Its Receptor in Hypertrophic Cardiomyopathy

1996 • 64 citations

Comparison of the positive inotropic effects of serotonin, histamine, angiotensin II, endothelin and isoprenaline in the isolated human right atrium

1993 • 63 citations

Endothelin ETA-Receptors Couple to Inositol Phosphate Formation and Inhibition of Adenylate Cyclase in Human Right Atrium

1994 • 63 citations

Expression of Endothelin Peptides and Mrna in the Human Heart

1996 • 60 citations

Potential paracrine role of the pericardium in the regulation of cardiac function

1998 • 56 citations

Contractile and arrhythmic effects of endothelin receptor agonists in human heart in vitro: blockade with SB 209670.

2000 • 56 citations

Influence of endothelin 1 on human atrial myocardium—myocardial function and subcellular pathways

1996 • 53 citations

Expression of Endothelin-1 and Endothelin-Converting Enzyme-1 mRNAs and Proteins in Failing Human Hearts

1998 • 49 citations

Effects of long-term therapy with bosentan on the progression of left ventricular dysfunction and remodeling in dogs with heart failure

2000 • 47 citations

Endothelin receptors in the human coronary artery, ventricle and atrium

1993 • 44 citations

Characterization of the binding of endothelin ET_B selective ligands in human and rat heart

1996 • 44 citations

Endothelin receptor pathway in human left ventricular myocytes: relation to contractility

2000 • 34 citations

Untitled

1998 • 31 citations

ET_A and ET_B Specific Ligands Synergistically Antagonize Endothelin‐1 Binding to an Atypical Endothelin Receptor in Primary Rat Astrocytes

1998 • 24 citations

Endothelin in congestive heart failure

1996 • 23 citations

Endothelin receptors and calcium translocation pathways in human airways

1999 • 16 citations

Alterations in plasma endothelin during passage through the left heart chambers before and after brief myocardial ischaemia

1993 • 5 citations