Cardiac Growth Factors in Human Hypertrophy

Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.

1978 • 7,562 citations

Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method.

1977 • 4,520 citations

Wall stress and patterns of hypertrophy in the human left ventricle.

1975 • 2,343 citations

Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro

1993 • 1,347 citations

Human Experimentation: Code of Ethics of W.M.A

1964 • 1,332 citations

THE CELLULAR AND MOLECULAR RESPONSE OF CARDIAC MYOCYTES TO MECHANICAL STRESS

1997 • 876 citations

Noninvasive determination of left ventricular end-systolic stress: validation of the method and initial application.

1982 • 668 citations

Cardiac hypertrophy. Mechanical, neural, and endocrine dependence.

1991 • 625 citations

Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy. Effects on coronary resistance, contractility, and relaxation.

1990 • 607 citations

Extracellular Matrix Remodeling in Heart Failure

1997 • 560 citations

Left ventricular myocardial structure in aortic valve disease before, intermediate, and late after aortic valve replacement.

1989 • 483 citations

Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell.

1998 • 460 citations

Angiotensin II Induces Apoptosis of Adult Ventricular MyocytesIn Vitro

1997 • 413 citations

Insulin-like growth factor-I induces hypertrophy with enhanced expression of muscle specific genes in cultured rat cardiomyocytes.

1993 • 401 citations

The spectrum of left ventricular hypertrophy in a general population sample: the Framingham Study.

1987 • 391 citations

Selective changes in cardiac gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding.

1993 • 359 citations

Alterations in cardiac gene expression during the transition from stable hypertrophy to heart failure. Marked upregulation of genes encoding extracellular matrix components.

1994 • 344 citations

Control of Cardiac Gene Expression by Mechanical Stress

1993 • 343 citations

Insulin-like growth factor-1 enhances ventricular hypertrophy and function during the onset of experimental cardiac failure.

1995 • 328 citations

Differential Cardiac Effects of Growth Hormone and Insulin-like Growth Factor1 in the Rat

1996 • 275 citations

Diastolic stiffness and myocardial structure in aortic valve disease before and after valve replacement.

1984 • 249 citations

Gene expression of the renin-angiotensin system in human tissues. Quantitative analysis by the polymerase chain reaction.

1993 • 244 citations

Signaling Pathways in Cardiac Myocyte Hypertrophy

1997 • 241 citations

Overexpression of Transforming Growth Factor-β1 and Insulin-Like Growth Factor-I in Patients With Idiopathic Hypertrophic Cardiomyopathy

1997 • 211 citations

Left ventricular function before and following aortic valve replacement.

1977 • 209 citations

Distribution and functional significance of cardiac angiotensin converting enzyme in hypertrophied rat hearts.

1993 • 191 citations

Pressure- and Volume-Induced Left Ventricular Hypertrophies Are Associated With Distinct Myocyte Phenotypes and Differential Induction of Peptide Growth Factor mRNAs

1995 • 190 citations

Noninvasive assessment of load reduction in patients with asymptomatic aortic regurgitation

1980 • 143 citations

Molecular mechanism of cardiac cellular hypertrophy by mechanical stress

1995 • 143 citations

Effect of Angiotensin-Converting Enzyme Inhibition on Myocardial Fibrosis and Function in Hypertrophied and Failing Myocardium From the Spontaneously Hypertensive Rat

1997 • 121 citations

Myocardial structure and function in patients with aortic valve disease and their relation to postoperative results

1978 • 116 citations

BASIC DETERMINANTS OF MYOCARDIAL HYPERTROPHY: A Review of Molecular Mechanisms

1997 • 106 citations

Regional angiotensin II production in essential hypertension and renal artery stenosis.

1993 • 103 citations

Production of angiotensins I and II at tissue sites in intact pigs

1992 • 85 citations

Human Vascular Renin-Angiotensin System and Its Functional Changes in Relation to Different Sodium Intakes

1998 • 83 citations

Evidence for the Existence of a Functional Cardiac Renin-Angiotensin System in Humans

1996 • 81 citations

Expression and localization of endothelin-1 and endothelin receptors in human meningiomas. Evidence for a role in tumoral growth.

1995 • 79 citations

Sarcoplasmic Reticulum Genes Are Upregulated in Mild Cardiac Hypertrophy But Downregulated in Severe Cardiac Hypertrophy Induced by Pressure Overload

1996 • 71 citations

Local stress, not systemic factors, regulate gene expression of the cardiac renin-angiotensin system in vivo: a comprehensive study of all its components in the dog.

1996 • 71 citations

Colonic H-K-ATPase β-subunit: identification in apical membranes and regulation by dietary K depletion

1999 • 56 citations

Effects of Constitutive Overexpression of Insulin-Like Growth Factor-1 on the Mechanical Characteristics and Molecular Properties of Ventricular Myocytes

1998 • 55 citations

Silent ischemia in unstable angina is related to an altered cardiac norepinephrine handling.

1993 • 45 citations

Plasma endothelin and renal endothelin are two distinct systems involved in volume homeostasis

1995 • 43 citations

5'-Aminolevulinate synthase activity is decreased in skeletal muscle of anemic rats

1992 • 41 citations

Endothelins and cardiac hypertrophy

1997 • 41 citations

Hypertrophic response to hemodynamic overload: role of load vs. renin-angiotensin system activation

1999 • 34 citations

Regulation of adult cardiocyte growth: effects of active and passive mechanical loading

1997 • 27 citations

Increased renal endothelin formation is associated with sodium retention and increased free water clearance

1998 • 27 citations

Overview of the Treatment of Heart Failure

1997 • 26 citations

Correlation Between Function and Proto-oncogene Expression in Isolated Working Rat Hearts Under Various Overload Conditions

1997 • 10 citations