Contribution of O⁶‐alkylguanine and N‐alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: New insights gained from studies of genetically engineered mammalian cell lines

Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents

1990 • 880 citations

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.

1990 • 736 citations

REGULATION AND EXPRESSION OF THE ADAPTIVE RESPONSE TO ALKYLATING AGENTS

1988 • 645 citations

Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine.

1990 • 292 citations

Apurinic sites as mutagenic intermediates

1985 • 283 citations

DNA synthesis with methylated poly(dC-dG) templates. Evidence for a competitive nature to miscoding by

1979 • 247 citations

Transfection and expression of human O⁶-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents

1991 • 219 citations

The relation between reaction kinetics and mutagenic action of mono-functional alkylating agents in higher eukaryotic systems

1979 • 211 citations

Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferase

1991 • 187 citations

Removal of O6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines

1981 • 183 citations

Self-destruction and tolerance in resistance of mammalian cells to alkylation damage

1992 • 173 citations

Human tumor cell strains defective in the repair of alkylation damage

1980 • 169 citations

Regulation of Repair of Alkylation Damage in Mammalian Genomes

1993 • 164 citations

Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase

1991 • 142 citations

Inducibility of the DNA Repair Gene Encoding O⁶-Methylguanine- DNA Methyltransferase in Mammalian Cells by DNA-Damaging Treatments

1991 • 138 citations

Inducibility of the DNA repair gene encoding O6-methylguanine-DNA methyltransferase in mammalian cells by DNA-damaging treatments.

1991 • 111 citations

Induction of mutations and sister-chromatid exchanges in Chinese hamster ovary cells by ethylating agents

1982 • 103 citations

Relationship of DNA repair phenotypes of human fibroblast and tumor strains to killing by N-methyl-N'-nitro-N-nitrosoguanidine.

1984 • 63 citations

Overexpression of human DNA repair protein N-methylpurine-DNA glycosylase results in the increased removal of N-methylpurines in DNA without a concomitant increase in resistance to alkylating agents in Chinese hamster ovary cells

1992 • 61 citations

Expression of the endogenous O6-methylguanine-DNA-methyltransferase protects Chinese hamster ovary cells from spontaneous G:C to A:T transitions.

1992 • 56 citations

The induction of SCE and chromosomal aberrations with relation to specific base methylation of DNA in Chinese hamster cells by N-methyl-N-nitrosourea and dimethyl sulphate

1982 • 43 citations

Alkylation-induced sister-chromatic exchanges correlate with reduced cell survival, not mutations

1982 • 41 citations

Dependency of the yield of sister-chromatid exchanges induced by alkylating agents on fixation time

1985 • 36 citations

The role of O⁶-alkylguanine in cell killing and mutagenesis in Chinese hamster ovary cells

1991 • 34 citations

Nucleophilic selectivity of alkylating agents and their hypermutability in Drosophila as predictors of carcinognic potency in rodents

1990 • 33 citations

Activity in clastogenicity and SCE assays, and aberration kinetics in chinese hamster V79-E cells

1980 • 33 citations

The relationship between sister-chromatid exchange induction and the formation of specific methylated DNA adducts in Chinese hamster ovary cells

1983 • 31 citations

Chinese hamster cells harbouring the Escherichia coli O⁶-alkylguanine alkyltransferase gene are less susceptible to sister chromatid exchange induction and chromosome damage by methylating agents

1986 • 30 citations

The interrelationship between SCE induction, cell survival, mutagenesis, aberration formation and DNA synthesis inhibition in V79 cells treated with N-methyl-N-nitrosourea or N-methyl-N′-nitro-N-nitrosoguanidine

1985 • 30 citations

The DNA Content of Some Mammalian Cells Measured by Flow Cytometry and its Influence on Radiation Sensitivity

1990 • 25 citations

Substrate specificity of 3‐methyladenine‐DNA glycosylase from calf thymus

1987 • 21 citations

Expression of human O⁶‐methylguanine‐DNA methyltransferase in chinese hamster ovary cells and restoration of cellular resistance to certain N‐nitroso compounds

1991 • 20 citations

DNA repair and chromosomal stability in the alkylating agent-hypersensitive Chinese hamster cell line 27-1

1990 • 18 citations

The origin of O6-methylguanine-DNA methyltransferase in Chinese hamster overy cells transfected with human DNA

1991 • 8 citations

Identification of human genes involved in repair and tolerance of DNA damage

1991 • 8 citations