Superantigens

Superantigens: Mechanism of T-Cell Stimulation and Role in Immune Responses

1991 • 783 citations

Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B

1991 • 675 citations

Evidence for the Effects of a Superantigen in Rheumatoid Arthritis

1991 • 632 citations

T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor.

1992 • 595 citations

A superantigen encoded in the open reading frame of the 3′ long terminal repeat of mouse mammary tumour virus

1991 • 394 citations

Clonal expansion precedes anergy and death of V_β8⁺ peripheral T cells responding to staphylococcal enterotoxin B in vivo

1991 • 330 citations

Selective Depletion in HIV Infection of T Cells that Bear Specific T Cell Receptor V _β Sequences

1991 • 322 citations

Analysis of T cell stimulation by superantigen plus major histocompatibility complex class II molecules or by CD3 monoclonal antibody: costimulation by purified adhesion ligands VCAM-1, ICAM-1, but not ELAM-1.

1991 • 293 citations

Clonal deletion of V β814-bearing T cells in mice transgenic for mammary tumour virus

1991 • 277 citations

Mls — a retrovirus exploits the immune system

1991 • 233 citations

Mutations defining functional regions of the superantigen staphylococcal enterotoxin B.

1992 • 208 citations

A Virus-Encoded "Superantigen" in a Retrovirus-Induced Immunodeficiency Syndrome of Mice

1991 • 198 citations

The Mycoplasma arthritidis T-cell mitogen MAM: a model superantigen

1991 • 168 citations

Transcriptional activation of IL-1 beta and tumor necrosis factor-alpha genes by MHC class II ligands.

1991 • 155 citations

Preferential V beta gene usage and lack of junctional sequence conservation among human T cell receptors specific for a tetanus toxin-derived peptide: evidence for a dominant role of a germline-encoded V region in antigen/major histocompatibility complex recognition.

1992 • 150 citations

Monoclonal antibody-targeted superantigens: a different class of anti-tumor agents.

1991 • 102 citations

T cell receptor V gene usage by human T cells stimulated with the superantigen streptococcal M protein.

1991 • 93 citations

Staphylococcal toxins bind to different sites on HLA-DR.

1991 • 86 citations

Selective Elements for the Vß Region of the T Cell Receptor: MIs and the Bacterial Toxic Mitogens

1991 • 82 citations

Structural analysis of a mouse mammary tumor virus superantigen.

1992 • 81 citations

Reduction of lupus nephritis in MRL/lpr mice by a bacterial superantigen treatment.

1991 • 75 citations

The Anti-CD3-Induced Syndrome: A Consequence of Massive In Vivo Cell Activation

1991 • 59 citations

Engagement of MHC-class II molecules by staphylococcal exotoxins delivers a comitogenic signal to human B cells.

1991 • 57 citations

Separation of T-cell-stimulating activity from streptococcal M protein

1992 • 56 citations

A recombinant C-terminal fragment of staphylococcal enterotoxin A binds to human MHC class II products but does not activate T cells.

1991 • 52 citations

Induction of interleukin-1 in human monocytes by the superantigen Staphylococcal Enterotoxin A requires the participation of T cells

1991 • 51 citations

Staphylococcal enterotoxin-dependent lysis of MHC class II negative target cells by cytolytic T lymphocytes.

1991 • 51 citations

Protection from experimental allergic encephalomyelitis by application of a bacterial superantigen

1992 • 49 citations

Staphylococcal exotoxins deliver activation signals to human T-cell clones via major histocompatibility complex class II molecules.

1991 • 48 citations

Localization of the immunologic activity in the superantigen Staphylococcal enterotoxin B using truncated recombinant fusion proteins.

1992 • 46 citations

Mutation of the disulfide loop in staphylococcal enterotoxin A. Consequences for T cell recognition.

1991 • 43 citations

Role of the adhesion molecule ICAM‐1 (CD54) in staphylococcal enterotoxin‐mediated cytotoxicity

1991 • 40 citations

Stimulator cell-dependent requirement for CD2- and LFA-1-mediated adhesions in T lymphocyte activation by superantigenic toxins

1992 • 17 citations

Activation of In Vitro Proliferation of Human T Cells by a Synthetic Peptide of Toxic Shock Syndrome Toxin 1

1991 • 17 citations