Direct binding of a synthetic multichain polypeptide to class II major histocompatibility complex molecules on antigen-presenting cells and stimulation of a specific T-cell line require processing of the polypeptide.

Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing.

1983 • 701 citations

Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells.

1982 • 576 citations

Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

1990 • 468 citations

Genetic Control of the Antibody Response: Relationship between Immune Response and Histocompatibility ( H-2 ) Type

1969 • 425 citations

GENETIC CONTROL OF THE ANTIBODY RESPONSE

1965 • 405 citations

GENETIC CONTROL OF THE IMMUNE RESPONSE

1972 • 355 citations

Differential requirements for antigen processing by macrophages for lysozyme-specific T cell hybridomas.

1984 • 272 citations

Studies on the chemical basis of the antigenicity of proteins. 5. Synthesis, characterization and immunogenicity of some multichain and linear polypeptides containing tyrosine

1962 • 250 citations

Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells: possible role of T cellbound Ia antigens as targets of immunoregulatory T cells.

1984 • 190 citations

Antigen conformation determines processing requirements for T-cell activation.

1984 • 181 citations

Capacity of intact proteins to bind to MHC class II molecules.

1989 • 129 citations

T cell recognition of fibrinogen. A determinant on the A alpha-chain does not require processing.

1988 • 100 citations

Requirements for the processing of antigen by antigen-presenting B cells. II. Biochemical comparison of the fate of antigen in B cell tumors and macrophages.

1982 • 93 citations

The molecular basis of the requirement for antigen processing of pigeon cytochrome c prior to T cell activation.

1985 • 89 citations

T-cell recognition of antigen and the Ia molecule as a ternary complex

1986 • 85 citations

Selective inhibition of antigen presentation to cloned T cells by protease inhibitors

1989 • 84 citations

Processing of tetanus toxin by human antigen-presenting cells. Evidence for donor and epitope-specific processing pathways.

1989 • 62 citations

The cellular pathway of antigen presentation: biochemical and functional analysis of antigen processing in dendritic cells and macrophages.

1986 • 58 citations

Phospholipids enhance the binding of peptides to class II major histocompatibility molecules.

1990 • 56 citations

Direct binding of a myasthenia gravis related epitope to MHC class II molecules on living murine antigen-presenting cells.

1989 • 48 citations

Processing by accessory cells for presentation to murine T cells of apamin, a disulfide-bonded 18 amino acid peptide.

1988 • 44 citations

Time dependence of B cell processing and presentation of peptide and native protein antigens.

1988 • 41 citations

Analysis of the biological functions and fine specificity of (T,G)-A--L specific. T cell clones

1986 • 33 citations

Analysis of antigen presentation by metabolically inactive accessory cells and their isolated membranes.

1985 • 27 citations

Antigen‐Ia interaction and the proteolytic processing of antigen: the structure of the antigen determines its restriction to the A or E molecule of the major histocompatibility complex

1986 • 21 citations

Antigen processing and the human T cell receptor repertoire for insulin.

1988 • 10 citations

Processing without proteolytic cleavage is required for recognition of insulin by T cells

1990 • 7 citations

Correlation between the biologic functions and the generation of lymphokines in T cell clones.

1989 • 7 citations