Supersensitive Ras activation in dendrites and spines revealed by two-photon fluorescence lifetime imaging

Principles of Fluorescence Spectroscopy

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A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications

2002 • 2,692 citations

A monomeric red fluorescent protein

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MAPK cascade signalling and synaptic plasticity

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An amplified sensitivity arising from covalent modification in biological systems.

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Red fluorescent protein

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Signaling to the Nucleus by an L-type Calcium Channel-Calmodulin Complex Through the MAP Kinase Pathway

2001 • 908 citations

Quantitative Fluorescence Resonance Energy Transfer Measurements Using Fluorescence Microscopy

1998 • 841 citations

An Acylation Cycle Regulates Localization and Activity of Palmitoylated Ras Isoforms

2005 • 816 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Ras and Rap Control AMPA Receptor Trafficking during Synaptic Plasticity

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Imaging protein molecules using FRET and FLIM microscopy

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Photon Upmanship: Why Multiphoton Imaging Is More than a Gimmick

1997 • 674 citations

RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs

1998 • 662 citations

SynGAP: a Synaptic RasGAP that Associates with the PSD-95/SAP90 Protein Family

1998 • 617 citations

Ras signalling on the endoplasmic reticulum and the Golgi

2002 • 612 citations

A Synaptic Ras-GTPase Activating Protein (p135 SynGAP) Inhibited by CaM Kinase II

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Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

1988 • 470 citations

Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras

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Visualization of the Spatial and Temporal Dynamics of Intracellular Signaling

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Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF

1995 • 424 citations

Estimating Intracellular Calcium Concentrations and Buffering without Wavelength Ratioing

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Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology

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Quantitative Analysis of the Complex between p21 and the Ras-binding Domain of the Human Raf-1 Protein Kinase

1995 • 348 citations

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Imaging Calcium Concentration Dynamics in Small Neuronal Compartments

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Integration of biochemical signalling in spines

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Extracellular Signal-Regulated Protein Kinase Activation Is Required for Metabotropic Glutamate Receptor-Dependent Long-Term Depression in Hippocampal Area CA1

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Fluorescence lifetime imaging for the two-photon microscope: time-domain and frequency-domain methods

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Monitoring Neural Activity and [Ca²⁺] with Genetically Encoded Ca²⁺Indicators

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2000 • 195 citations

Multiphoton-FLIM Quantification of the EGFP-mRFP1 FRET Pair for Localization of Membrane Receptor-Kinase Interactions

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Neuronal L-Type Calcium Channels Open Quickly and Are Inhibited Slowly

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Ras Activation by Insulin and Epidermal Growth Factor through Enhanced Exchange of Guanine Nucleotides on p21^ras

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Frequency-dependent propagation of sodium action potentials in dendrites of hippocampal CA1 pyramidal neurons

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Rap2 as a Slowly Responding Molecular Switch in the Rap1 Signaling Cascade

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DsRed as a Potential FRET Partner with CFP and GFP

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Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras.

1993 • 97 citations

Structural Determinants of Ras-Raf Interaction Analyzed in Live Cells

2002 • 84 citations

Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations

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<title>Time-resolved fluorescence imaging and background rejection by two-photon excitation in laser-scanning microscopy</title>

1992 • 80 citations

CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+

2005 • 76 citations

Biolistic Transfection of Neurons

2000 • 69 citations

The Ca2+-dependent Lipid Binding Domain of P120GAP Mediates Protein-Protein Interactions with Ca2+-dependent Membrane-binding Proteinss

1996 • 68 citations

Discrimination of Amino Acids Mediating Ras Binding from Noninteracting Residues Affecting Raf Activation by Double Mutant Analysis

1997 • 33 citations