TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

Toll-Like Receptors

2003 • 6,127 citations

Toll-like receptor control of the adaptive immune responses

2004 • 4,092 citations

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow

1999 • 2,950 citations

CpG Motifs in Bacterial DNA and Their Immune Effects

2002 • 2,520 citations

An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.

1993 • 2,410 citations

Disseminated tuberculosis in interferon gamma gene-disrupted mice.

1993 • 1,982 citations

Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice

1995 • 1,643 citations

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

2004 • 1,326 citations

Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells

2003 • 1,189 citations

Identification of nitric oxide synthase as a protective locus against tuberculosis

1997 • 1,161 citations

Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells

2005 • 1,142 citations

Genetic Dissection of Immunity to Mycobacteria: The Human Model

2002 • 960 citations

Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages

1999 • 829 citations

Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection.

1992 • 771 citations

Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

2002 • 724 citations

Induction of Direct Antimicrobial Activity Through Mammalian Toll-Like Receptors

2001 • 709 citations

Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin

2005 • 625 citations

Structural Deficiencies in Granuloma Formation in TNF Gene-Targeted Mice Underlie the Heightened Susceptibility to Aerosol Mycobacterium tuberculosis Infection, Which Is Not Compensated for by Lymphotoxin

1999 • 612 citations

A type I interferon autocrine–paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells

2005 • 530 citations

Toll‐like receptor 9 binds single‐stranded CpG‐DNA in a sequence‐ and pH‐dependent manner

2004 • 493 citations

Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosis.

1999 • 486 citations

Antitumor Activity of Deoxyribonucleic Acid Fraction From <italic>Mycobacterium bovis</italic> BCG. I. Isolation, Physicochemical Characterization, and Antitumor Activity<xref ref-type="fn" rid="FN2">2</xref>

1984 • 471 citations

Cutting Edge: Toll-Like Receptor (TLR)2- and TLR4-Mediated Pathogen Recognition in Resistance to Airborne Infection with Mycobacterium tuberculosis

2002 • 454 citations

The Arg753Gln polymorphism of the human Toll-like receptor 2 gene in tuberculosis disease

2004 • 427 citations

Mice Deficient in CD4 T Cells Have Only Transiently Diminished Levels of IFN-γ, Yet Succumb to Tuberculosis

1999 • 401 citations

DNA from Bacteria, but Not from Vertebrates, Induces Interferons, Activates Natural Killer Cells and Inhibits Tumor Growth

1992 • 370 citations

Susceptibility of Mice Deficient in CD1D or TAP1 to Infection with Mycobacterium tuberculosis

1999 • 361 citations

Toll-Like Receptor 4 Expression Is Required to Control ChronicMycobacterium tuberculosisInfection in Mice

2002 • 355 citations

Different Toll-like receptor agonists induce distinct macrophage responses

2001 • 349 citations

Toll-Like Receptor 2-Deficient Mice Succumb to Mycobacterium tuberculosis Infection

2004 • 335 citations

Depletion of Cd4+ T Cells Causes Reactivation of Murine Persistent Tuberculosis despite Continued Expression of Interferon γ and Nitric Oxide Synthase 2

2000 • 335 citations

TLR9 Is Localized in the Endoplasmic Reticulum Prior to Stimulation

2004 • 327 citations

IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection.

1995 • 325 citations

The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection.

1995 • 308 citations

Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88

2004 • 294 citations

Toll-like receptor pathways in the immune responses to mycobacteria

2004 • 269 citations

Differential Effects of a Toll-Like Receptor Antagonist on Mycobacterium tuberculosis-Induced Macrophage Responses

2001 • 267 citations

Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients

2001 • 259 citations

Resistance ranking of some common inbred mouse strains to Mycobacterium tuberculosis and relationship to major histocompatibility complex haplotype and Nramp1 genotype

1998 • 248 citations

Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88

2004 • 246 citations

Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase–dependent lipoxin production

2005 • 245 citations

Toll-Like Receptor 2 Arg677Trp Polymorphism Is Associated with Susceptibility to Tuberculosis in Tunisian Patients

2004 • 245 citations

Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case–control disease association studies☆☆This work was supported by Programs for Genomic Applications, Grant U01 HL66795, Innate Immunity in Heart, Lung and Blood Disease, from the National Heart, Lung and Blood Institute.

2003 • 207 citations

Mice Lacking Myeloid Differentiation Factor 88 Display Profound Defects in Host Resistance and Immune Responses to Mycobacterium avium Infection Not Exhibited by Toll-Like Receptor 2 (TLR2)- and TLR4-Deficient Animals

2003 • 198 citations

MyD88-Deficient Mice Display a Profound Loss in Resistance toMycobacterium tuberculosisAssociated with Partially Impaired Th1 Cytokine and Nitric Oxide Synthase 2 Expression

2004 • 193 citations

Mycobacterial Infection in TLR2 and TLR6 Knockout Mice

2003 • 192 citations

Interleukin-12 production by human monocytes infected with Mycobacterium tuberculosis: role of phagocytosis

1996 • 159 citations

The role of Toll-like receptors in combating mycobacteria

2004 • 152 citations

MyD88 Primes Macrophages for Full-Scale Activation by Interferon-γ yet Mediates Few Responses to Mycobacterium tuberculosis

2003 • 146 citations

IL-6 and IL-10 Induction from Dendritic Cells in Response to Mycobacterium tuberculosis Is Predominantly Dependent on TLR2-Mediated Recognition

2004 • 135 citations

How BCG Led to the Discovery of Immunostimulatory DNA

1999 • 128 citations

Maintenance of Pulmonary Th1 Effector Function in Chronic Tuberculosis Requires Persistent IL-12 Production

2005 • 126 citations

IFN-αβ-Dependent, IFN-γ Secretion by Bone Marrow-Derived Macrophages Controls an Intracellular Bacterial Infection

2001 • 119 citations

Requirement for TLR9 in the Immunomodulatory Activity of Propionibacterium acnes

2005 • 112 citations

Expression of Many Immunologically Important Genes in Mycobacterium tuberculosis-Infected Macrophages Is Independent of Both TLR2 and TLR4 but Dependent on IFN-αβ Receptor and STAT1

2005 • 105 citations

Role of Interleukin (IL)‐1 Type 1 Receptor in Mycobacterial Infection

2001 • 94 citations

Contribution of IL-18 to Th1 Response and Host Defense Against Infection by Mycobacterium tuberculosis: A Comparative Study with IL-12p40

2002 • 88 citations

Toll-Like Receptor 4-Defective C3H/HeJ Mice Are Not More Susceptible than Other C3H Substrains to Infection withMycobacterium tuberculosis

2003 • 83 citations

Immunostimulatory DNA Sequences Influence the Course of Adjuvant Arthritis

2002 • 78 citations

A Novel Nonclassic β 2-Microglobulin–Restricted Mechanism Influencing Early Lymphocyte Accumulation and Subsequent Resistance to Tuberculosis in the Lung

2000 • 72 citations

Cutting Edge: In Vivo Induction of Integrated HIV-1 Expression by Mycobacteria Is Critically Dependent on Toll-Like Receptor 2

2003 • 58 citations

Long-Term Control ofMycobacterium bovisBCG Infection in the Absence of Toll-Like Receptors (TLRs): Investigation of TLR2-, TLR6-, or TLR2-TLR4-Deficient Mice

2004 • 57 citations

Deleted Work

1955 • 0 citations