Mycobacterium tuberculosis Lipoarabinomannan-mediated IRAK-M Induction Negatively Regulates Toll-like Receptor-dependent Interleukin-12 p40 Production in Macrophages

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Innate immune recognition: mechanisms and pathways

2000 • 1,451 citations

IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling

2002 • 1,224 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

Dendritic cell regulation of TH1-TH2 development

2000 • 1,136 citations

Mycobacteria Target DC-SIGN to Suppress Dendritic Cell Function

2002 • 1,037 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

The IL-12 Family of Heterodimeric Cytokines

2003 • 889 citations

Impairment of Mycobacterial Immunity in Human Interleukin-12 Receptor Deficiency

1998 • 837 citations

Severe Mycobacterial and Salmonella Infections in Interleukin-12 Receptor-Deficient Patients

1998 • 812 citations

The Phosphatidylinositol 3-Kinase-Akt Pathway Limits Lipopolysaccharide Activation of Signaling Pathways and Expression of Inflammatory Mediators in Human Monocytic Cells

2002 • 787 citations

Tlr4: central component of the sole mammalian LPS sensor

2000 • 764 citations

Toll signaling pathways in the innate immune response

2000 • 637 citations

SOCS-1 Participates in Negative Regulation of LPS Responses

2002 • 636 citations

SOCS1/JAB Is a Negative Regulator of LPS-Induced Macrophage Activation

2002 • 618 citations

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.

1991 • 593 citations

PI3K-mediated negative feedback regulation of IL-12 production in DCs

2002 • 534 citations

Regulation of Interleukin 12 p40 Expression through an NF-κB Half-Site

1995 • 495 citations

IRAK-M Is a Novel Member of the Pelle/Interleukin-1 Receptor-associated Kinase (IRAK) Family

1999 • 445 citations

The CD14 Ligands Lipoarabinomannan and Lipopolysaccharide Differ in Their Requirement for Toll-Like Receptors

1999 • 445 citations

Mannosylated Lipoarabinomannans Inhibit IL-12 Production by Human Dendritic Cells: Evidence for a Negative Signal Delivered Through the Mannose Receptor

2001 • 415 citations

Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection.

1998 • 405 citations

Molecular Mechanisms of the Induction of IL-12 and Its Inhibition by IL-10

1998 • 397 citations

Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3(Mkk3)-deficient mice

1999 • 390 citations

Interplay between mycobacteria and host signalling pathways

2004 • 356 citations

Binding of the terminal mannosyl units of lipoarabinomannan from a virulent strain of Mycobacterium tuberculosis to human macrophages.

1994 • 347 citations

The mannose receptor: linking homeostasis and immunity through sugar recognition

2004 • 336 citations

Multiple Control Elements Mediate Activation of the Murine and Human Interleukin 12 p40 Promoters: Evidence of Functional Synergy between C/EBP and Rel Proteins

1997 • 310 citations

Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages

2000 • 301 citations

IL-1 Receptor-Associated Kinase Modulates Host Responsiveness to Endotoxin

2000 • 290 citations

Immune evasion by Mycobacterium tuberculosis: living with the enemy

2003 • 282 citations

A Prominent Role for Sp1 During Lipopolysaccharide- Mediated Induction of the IL-10 Promoter in Macrophages

2000 • 276 citations

Lipoarabinomannans: from structure to biosynthesis

2003 • 268 citations

The Cell Surface Receptor DC-SIGN Discriminates betweenMycobacterium Species through Selective Recognition of the Mannose Caps on Lipoarabinomannan

2003 • 264 citations

Toll-Like Receptor 2 (TLR2)-Dependent-Positive and TLR2-Independent-Negative Regulation of Proinflammatory Cytokines by Mycobacterial Lipomannans

2004 • 253 citations

Lipoarabinomannan of Mycobacterium tuberculosis. Capping with mannosyl residues in some strains.

1992 • 240 citations

Small Interfering RNA-Mediated Gene Silencing in T Lymphocytes

2002 • 221 citations

Inositol Phosphate Capping of the Nonreducing Termini of Lipoarabinomannan from Rapidly Growing Strains of Mycobacterium

1995 • 218 citations

Differences in mannose receptor-mediated uptake of lipoarabinomannan from virulent and attenuated strains of Mycobacterium tuberculosis by human macrophages.

1996 • 196 citations

Selective induction of transforming growth factor beta in human monocytes by lipoarabinomannan of Mycobacterium tuberculosis

1996 • 176 citations

Lipoarabinomannan from Mycobacterium tuberculosis Promotes Macrophage Survival by Phosphorylating Bad through a Phosphatidylinositol 3-Kinase/Akt Pathway

2001 • 176 citations

Lipoarabinomannan of Mycobacterium tuberculosisPromotes Protein Tyrosine Dephosphorylation and Inhibition of Mitogen-activated Protein Kinase in Human Mononuclear Phagocytes

1998 • 162 citations

Mycobacterium tuberculosisLipomannan Induces Apoptosis and Interleukin-12 Production in Macrophages

2004 • 155 citations

Identification and Characterization of a Novel Ets-2-related Nuclear Complex Implicated in the Activation of the Human Interleukin-12 p40 Gene Promoter

1997 • 143 citations

Mycobacterial lipoarabinomannans: modulators of dendritic cell function and the apoptotic response

2002 • 143 citations

Lack of Both Types 1 and 2 Cytokines, Tissue Inflammatory Responses, and Immune Protection During Pulmonary Infection byMycobacterium bovisBacille Calmette-Guérin in IL-12-Deficient Mice

1998 • 140 citations

Toll-like receptors: how they work and what they do

2002 • 138 citations

Structural features of lipoarabinomannan from Mycobacterium bovis BCG. Determination of molecular mass by laser desorption mass spectrometry

1993 • 127 citations

Structure and antigenicity of lipoarabinomannan from Mycobacterium bovis BCG

1993 • 125 citations

Mannosylated Lipoarabinomannan AntagonizesMycobacterium tuberculosis–Induced Macrophage Apoptosis by Altering Ca⁺²‐Dependent Cell Signaling

2000 • 117 citations

Mycobacterium smegmatis Phosphoinositols-Glyceroarabinomannans

1997 • 103 citations

Mechanism of Inactivation of NF-κB by a Viral Homologue of IκBα

2000 • 81 citations

Mannose-Containing Molecular Patterns Are Strong Inducers of Cyclooxygenase-2 Expression and Prostaglandin E2 Production in Human Macrophages

2005 • 53 citations

Silencing of Bruton's tyrosine kinase (Btk) using short interfering RNA duplexes (siRNA)

2002 • 51 citations

Optimizing RNA interference for application in mammalian cells

2004 • 48 citations