The Role of TGFβ in the Pathogenesis of Human Tuberculosis

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

Negative regulation of transforming growth factor-β by the proteoglycan decorin

1990 • 1,490 citations

Transforming growth factor type beta induces monocyte chemotaxis and growth factor production.

1987 • 1,287 citations

Transforming Growth Factor-β: Biological Function and Chemical Structure

1986 • 1,198 citations

Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

1992 • 984 citations

Expression and secretion of type beta transforming growth factor by activated human macrophages.

1987 • 981 citations

Tuberculosis: Pathogenesis, Protection and Control

1996 • 962 citations

Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.

1991 • 794 citations

Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1.

1992 • 675 citations

Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.

1990 • 647 citations

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1988 • 548 citations

Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10

1992 • 516 citations

Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.

1990 • 507 citations

Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation.

1989 • 502 citations

Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways.

1994 • 482 citations

Inhibition of cytokine production by cyclosporin A and transforming growth factor beta.

1987 • 466 citations

Transforming growth factor beta (TGF-?) in inflammation: A cause and a cure

1992 • 417 citations

Tuberculosis: Pathogenesis, protection, and control

1995 • 409 citations

Processing of Transforming Growth Factor β1 Precursor by Human Furin Convertase

1995 • 395 citations

Cytokine production at the site of disease in human tuberculosis

1993 • 379 citations

Local production of tumor necrosis factor and IFN-gamma in tuberculous pleuritis.

1990 • 318 citations

Transforming Growth Factor β as a Predictor of Liver and Lung Fibrosis after Autologous Bone Marrow Transplantation for Advanced Breast Cancer

1993 • 318 citations

Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor beta (TGF-beta).

1991 • 309 citations

Transforming growth factor β: a matter of life and death

1994 • 306 citations

Global Burden of Tuberculosis

2014 • 300 citations

Transforming growth factor-beta 1 modulates the expression of class II histocompatibility antigens on human cells.

1988 • 298 citations

Cytokine control of parasite-specific anergy in human lymphatic filariasis. Preferential induction of a regulatory T helper type 2 lymphocyte subset.

1993 • 293 citations

Role for carbohydrate structures inTGF-β1 latency

1989 • 270 citations

Characterization of fibronectin-binding antigens released by Mycobacterium tuberculosis and Mycobacterium bovis BCG

1988 • 268 citations

Enhanced production of TGF-beta by blood monocytes from patients with active tuberculosis and presence of TGF-beta in tuberculous granulomatous lung lesions.

1995 • 265 citations

Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts.

1988 • 241 citations

Transforming growth factor beta is a potent inhibitor of interleukin 1 (IL-1) receptor expression: proposed mechanism of inhibition of IL-1 action.

1990 • 229 citations

Transforming growth factor beta as a virulence mechanism for Leishmania braziliensis.

1993 • 217 citations

The role of gamma-interferon, vitamin D3 metabolites and tumour necrosis factor in the pathogenesis of tuberculosis.

1987 • 215 citations

Cross-modulation by transforming growth factor beta in human tuberculosis: suppression of antigen-driven blastogenesis and interferon gamma production.

1996 • 212 citations

Transforming growth factor beta enhances integrin expression and type IV collagenase secretion in human monocytes.

1993 • 211 citations

T cell cytokine responses in persons with tuberculosis and human immunodeficiency virus infection.

1994 • 204 citations

Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis.

1995 • 193 citations

Regulation of alveolar macrophage transforming growth factor-beta secretion by corticosteroids in bleomycin-induced pulmonary inflammation in the rat.

1993 • 185 citations

Absence of a prominent Th2 cytokine response in human tuberculosis

1996 • 181 citations

Tumor necrosis factor-alpha and interferon-gamma suppress the activation of human type I collagen gene expression by transforming growth factor-beta 1. Evidence for two distinct mechanisms of inhibition at the transcriptional and posttranscriptional levels.

1990 • 178 citations

Selective induction of transforming growth factor beta in human monocytes by lipoarabinomannan of Mycobacterium tuberculosis

1996 • 176 citations

Differential expression of the TGF‐β isoforms in embryogenesis suggests specific roles in developing and adult tissues

1992 • 175 citations

Enhancement Of Intracellular Growth Of Mycobacterium Tuberculosis In Human Monocytes by Transforming Growth Factor- l

1994 • 172 citations

Defective interleukin 2 production and responsiveness in human pulmonary tuberculosis.

1986 • 172 citations

Retinoic acid receptors and retinoid X receptor-alpha down-regulate the transforming growth factor-beta 1 promoter by antagonizing AP-1 activity.

1993 • 160 citations

Regulatory effects of transforming growth factor-beta on IL-2- and IL-4-dependent T cell-cycle progression.

1990 • 159 citations

The Immune Response in Human Tuberculosis—Implications for Tuberculosis Control

1997 • 158 citations

In vitrorestoration of T cell responses in tuberculosis and augmentation of monocyte effector function againstMycobacterium tuberculosisby natural inhibitors of transforming growth factor β

1997 • 148 citations

The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice.

1996 • 147 citations

Expression of tumor necrosis factor in vitro by human mononuclear phagocytes stimulated with whole Mycobacterium bovis BCG and mycobacterial antigens

1988 • 145 citations

Effect of transforming growth factor-beta on early and late activation events in human T cells.

1993 • 137 citations

Differential effect of transforming growth factor β on the synthesis of T_h1‐ and T_h2‐like lymphokines by human T lymphocytes

1992 • 131 citations

Transforming growth factor beta 1 induces cachexia and systemic fibrosis without an antitumor effect in nude mice.

1991 • 121 citations

Increase in tumor necrosis factor alpha- and interleukin-6-secreting cells in peripheral blood mononuclear cells from subjects infected with Mycobacterium tuberculosis

1991 • 120 citations

Activation of Latent Transforming Growth Factor ß

1993 • 118 citations

Direct stimulation of monocyte release of interleukin 1 by mycobacterial protein antigens.

1986 • 93 citations

Immunohistochemical localization of transforming growth factor-beta 1 in the nonnecrotizing granulomas of pulmonary sarcoidosis.

1994 • 87 citations

Increased Interleukin-1 Production and Monocyte Suppressor Cell Activity Associated with Human Tuberculosis^1,2

1986 • 87 citations

Decreased production of TGF-beta 1 by human alveolar macrophages compared with blood monocytes.

1996 • 79 citations

Differential regulation of the expression of transforming growth factor‐βs 1 and 2 by retinoic acid, epidermal growth factor, and dexamethasone in NRK‐49F and A549 cells

1991 • 77 citations

TGFβ and HIV Infectiona

1993 • 74 citations

Induction of transforming growth factor beta 1 by purified protein derivative of Mycobacterium tuberculosis

1995 • 74 citations

γ‐Interferon‐Induced Activation of Latent Transforming Growth Factor‐β by Human Monocytes

1990 • 73 citations

Mechanisms of Pathogenesis in Tuberculosis

2014 • 66 citations

T Lymphocytic and Immature Macrophage Alveolitis in Active Pulmonary Tuberculosis

1996 • 64 citations

Deficient immune interferon production in tuberculosis.

1985 • 62 citations

Defective gamma-interferon production in peripheral blood leukocytes of patients with acute tuberculosis

1986 • 61 citations

Cytotoxicity in human mucosal and cutaneous leishmaniasis

1995 • 61 citations

Transforming growth factor-beta prevents stem cell factor-mediated rescue of mast cells from apoptosis after IL-3 deprivation.

1994 • 60 citations

Induction of monocyte expression of tumor necrosis factor alpha by the 30-kD alpha antigen of Mycobacterium tuberculosis and synergism with fibronectin.

1996 • 60 citations

Expression of functional interleukin 2 receptors by peripheral blood monocytes from patients with active pulmonary tuberculosis.

1990 • 59 citations

Quantitative and Qualitative Studies on the Major Extracellular Antigen ofMycobacterium tuberculosisH37Rv andMycobacterium bovisBCG

1990 • 52 citations

Identification by two-dimensional gel electrophoresis of a 58-kilodalton tumor necrosis factor-inducing protein of Mycobacterium tuberculosis

1993 • 46 citations

Type beta 1 transforming growth factor gene expression. A corrected mRNA structure reveals a downstream phorbol ester responsive element in human cells.

1990 • 42 citations

Vaccination routes that fail to elicit protective immunity against Schistosoma mansoni induce the production of TGF-beta, which down-regulates macrophage antiparasitic activity.

1995 • 40 citations

Lysosomal and cytosolic sialidases in rabbit alveolar macrophages: demonstration of increased lysosomal activity after in vivo activation with bacillus Calmette-Guerin

1987 • 34 citations

Specificity and reciprocity in the interactions between TGF-beta and macrophage inflammatory protein-1 alpha.

1996 • 28 citations

Deleted Work

1955 • 0 citations