The human LINE-1 reverse transcriptase:effect of deletions outside the common reverse transcriptase domain

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

1997 • 2,256 citations

Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor

1992 • 1,887 citations

hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

1997 • 1,786 citations

Origin and evolution of retroelements based upon their reverse transcriptase sequences.

1990 • 1,351 citations

Human L1 Retrotransposon Encodes a Conserved Endonuclease Required for Retrotransposition

1996 • 1,093 citations

Current Protocols in Molecular Biology

1989 • 1,007 citations

High Frequency Retrotransposition in Cultured Mammalian Cells

1996 • 989 citations

Haemophilia A resulting from de novo insertion of L1 sequences represents a novel mechanism for mutation in man

1988 • 883 citations

Reverse Transcriptase Encoded by a Human Transposable Element

1991 • 748 citations

The origin of interspersed repeats in the human genome

1996 • 595 citations

Origins and Evolutionary Relationships of Retroviruses

1989 • 581 citations

Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer.

1992 • 551 citations

Many human L1 elements are capable of retrotransposition

1997 • 436 citations

Isolation of an Active Human Transposable Element

1991 • 433 citations

Identification, characterization, and cell specificity of a human LINE-1 promoter.

1990 • 419 citations

Cytoplasmic ribonucleoprotein complexes containing human LINE-1 protein and RNA.

1996 • 338 citations

Unit-length line-1 transcripts in human teratocarcinoma cells.

1988 • 296 citations

A new retrotransposable human L1 element from the LRE2 locus on chromosome 1q produces a chimaeric insertion

1994 • 226 citations

An actively retrotransposing, novel subfamily of mouse L1 elements

1998 • 187 citations

Sequence-specific single-strand RNA binding protein encoded by the human LINE-1 retrotransposon

1997 • 187 citations

Insertion and/or deletion of many repeated DNA sequences in human and higher ape evolution.

1986 • 183 citations

Binding of the ubiquitous nuclear transcription factor YY1 to a cis regulatory sequence in the human LINE-1 transposable element

1993 • 137 citations

The LINE-1 DNA sequences in four mammalian orders predict proteins that conserve homologies to retrovirus proteins

1987 • 132 citations

Evolution of retroposons by acquisition or deletion of retrovirus-like genes.

1991 • 129 citations

The site-specific ribosomal DNA insertion element R1Bm belongs to a class of non-long-terminal-repeat retrotransposons.

1988 • 128 citations

Translation of LINE-1 DNA elements in vitro and in human cells.

1990 • 123 citations

Identification of an internal cis-element essential for the human Li transcription and a nuclear factor(s) binding to the element

1992 • 110 citations

The mauriceville plasmid reverse transcriptase can initiate cDNA synthesis de novo and may be related to reverse transcriptase and DNA polymerase progenitor

1993 • 105 citations

Synchronous expression of LINE-1 RNA and protein in mouse embryonal carcinoma cells.

1993 • 98 citations

Undermethylation of specific LINE-1 sequences in human cells producing a LINE-1 -encoded protein

1993 • 96 citations

An in vivo assay for the reverse transcriptase of human retrotransposon L1 in Saccharomyces cerevisiae.

1994 • 93 citations

Functional differences between the human LINE retrotransposon and retroviral reverse transcriptases for invivo mRNA reverse transcription

1997 • 75 citations

Tadl-1, an active LINE-like element of Neurospora crassa

1994 • 55 citations

A cloned I-factor is fully functional in Drosophila melanogaster

1988 • 53 citations

The Site-Specific Ribosomal DNA Insertion Element R1Bm Belongs to a Class of Non-Long-Terminal-Repeat Retrotransposons

1988 • 50 citations

Synchronous Expression of LINE-1 RNA and Protein in Mouse Embryonal Carcinoma Cells

1993 • 49 citations

LINE-1 retrotransposon expression in pediatric germ cell tumors

1993 • 41 citations

Ribonuclease and high salt sensitivity of the ribonucleoprotein complex formed by the human LINE-1 retrotransposon

1997 • 41 citations

An In Vivo Assay for the Reverse Transcriptase of Human Retrotransposon L1 in Saccharomyces cerevisiae

1994 • 31 citations

Promoter Binding Proteins of an Active Human L1 Retrotransposon

1993 • 20 citations