Reverse Transcriptase Encoded by a Human Transposable Element

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Origin and evolution of retroelements based upon their reverse transcriptase sequences.

1990 • 1,351 citations

NONVIRAL RETROPOSONS: GENES, PSEUDOGENES, AND TRANSPOSABLE ELEMENTS GENERATED BY THE REVERSE FLOW OF GENETIC INFORMATION

1986 • 1,032 citations

Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method.

1988 • 983 citations

Haemophilia A resulting from de novo insertion of L1 sequences represents a novel mechanism for mutation in man

1988 • 883 citations

The structure of an antigenic determinant in a protein

1984 • 841 citations

[35] Epitope tagging and protein surveillance

1991 • 526 citations

A de novo Alu insertion results in neurofibromatosis type 1

1991 • 448 citations

Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase

1981 • 439 citations

Isolation of an Active Human Transposable Element

1991 • 433 citations

Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition.

1983 • 378 citations

A history of the human fetal globin gene duplication

1981 • 349 citations

The sequence of a large L1Md element reveals a tandemly repeated 5' end and several features found in retrotransposons.

1986 • 326 citations

Site-specific mutagenesis of AIDS virus reverse transcriptase

1987 • 319 citations

Origin of the human L1 elements: Proposed progenitor genes deduced from a consensus DNA sequence

1987 • 312 citations

Structure and function of the yeast URA3 gene: expression in Escherichia coli

1984 • 311 citations

Retroviruses and Retrotransposons: The role of reverse transcription in shaping the eukaryotic genome

1985 • 273 citations

LINE-1: A mammalian transposable element

1987 • 224 citations

L1 family of repetitive DNA sequences in primates may be derived from a sequence encoding a reverse transcriptase-related protein

1986 • 218 citations

Ribonucleoprotein particles with LINE-1 RNA in mouse embryonal carcinoma cells.

1991 • 215 citations

The SPT3 gene is required for normal transcription of Ty elements in S. cerevisiae

1984 • 212 citations

The DNA intermediate in yeast Ty1 element transposition copurifies with virus-like particles: Cell-free Ty1 transposition

1988 • 202 citations

Reverse transcription in the eukaryotic genome: retroviruses, pararetroviruses, retrotransposons, and retrotranscripts.

1985 • 166 citations

The functions and relationships of Ty-VLP proteins in yeast reflect those of mammalian retroviral proteins

1987 • 144 citations

An indicator gene for detection of germline retrotransposition in transgenic Drosophila demonstrates RNA-mediated transposition of the LINE I element.

1991 • 97 citations

Saccharomyces cerevisiae SPT3 gene is required for transposition and transpositional recombination of chromosomal Ty elements.

1986 • 96 citations

Evidence for retrotransposition of the I factor, a LINE element of Drosophila melanogaster.

1991 • 91 citations

Host genes that influence transposition in yeast: the abundance of a rare tRNA regulates Ty1 transposition frequency.

1990 • 83 citations

Processing of TY1 proteins and formation of Ty1 virus-like particles in Saccharomyces cerevisiae

1987 • 74 citations

Proteolytic processing of pol-TYB proteins from the yeast retrotransposon Ty1

1991 • 71 citations

Ty1 transposition in Saccharomyces cerevisiae is nonrandom.

1989 • 61 citations

Reverse transcriptase encoded by a retrotransposon from the trypanosomatid Crithidia fasciculata.

1991 • 58 citations

Inhibition of Ty1 transposition by mating pheromones in Saccharomyces cerevisiae.

1991 • 53 citations

Tad, a LINE-like transposable element of Neurospora, can transpose between nuclei in heterokaryons.

1990 • 51 citations

Authentic reverse transcriptase is coded by jockey, a mobile Drosophila element related to mammalian LINEs.

1991 • 46 citations

Retrovirus-like vectors for Saccharomyces cerevisiae: integration of foreign genes controlled by efficient promoters into yeast chromosomal DNA

1988 • 21 citations