High Frequency Retrotransposition in Cultured Mammalian Cells

Basic local alignment search tool

1990 • 87,358 citations

Origin and evolution of retroelements based upon their reverse transcriptase sequences.

1990 • 1,351 citations

Stable replication of plasmids derived from Epstein–Barr virus in various mammalian cells

1985 • 1,303 citations

Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: A mechanism for non-LTR retrotransposition

1993 • 1,129 citations

Human L1 Retrotransposon Encodes a Conserved Endonuclease Required for Retrotransposition

1996 • 1,093 citations

Haemophilia A resulting from de novo insertion of L1 sequences represents a novel mechanism for mutation in man

1988 • 883 citations

Ty elements transpose through an RNA intermediate

1985 • 837 citations

Reverse Transcriptase Encoded by a Human Transposable Element

1991 • 748 citations

[6] Efficient site-directed mutagenesis using uracil-containing DNA

1991 • 644 citations

Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer.

1992 • 551 citations

Insertional Mutagenesis of the Drosophila Genome with Single P Elements

1988 • 533 citations

Isolation of an Active Human Transposable Element

1991 • 433 citations

Identification, characterization, and cell specificity of a human LINE-1 promoter.

1990 • 419 citations

Cytoplasmic ribonucleoprotein complexes containing human LINE-1 protein and RNA.

1996 • 338 citations

Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma

1988 • 320 citations

Origin of the human L1 elements: Proposed progenitor genes deduced from a consensus DNA sequence

1987 • 312 citations

Group II intron mobility occurs by target DNA-primed reverse transcription

1995 • 278 citations

Single-step selection for Ty1 element retrotransposition.

1991 • 260 citations

A new retrotransposable human L1 element from the LRE2 locus on chromosome 1q produces a chimaeric insertion

1994 • 226 citations

LINE-1: A mammalian transposable element

1987 • 224 citations

L1 family of repetitive DNA sequences in primates may be derived from a sequence encoding a reverse transcriptase-related protein

1986 • 218 citations

Ribonucleoprotein particles with LINE-1 RNA in mouse embryonal carcinoma cells.

1991 • 215 citations

A group II intron RNA is a catalytic component of a DNA endonuclease involved in intron mobility

1995 • 212 citations

RNA Template Requirements for Target DNA-Primed Reverse Transcription by the R2 Retrotransposable Element

1995 • 212 citations

Glycine receptor β–subunit gene mutation in spastic mouse associated with LINE–1 element insertion

1994 • 208 citations

Insertion of a 5' truncated L1 element into the 3' end of exon 44 of the dystrophin gene resulted in skipping of the exon during splicing in a case of Duchenne muscular dystrophy.

1993 • 197 citations

The spastic mouse: Aberrant splicing of glycine receptor β subunit mRNA caused by intronic insertion of Ll element

1994 • 185 citations

Conservation throughout mammalia and extensive protein-encoding capacity of the highly repeated DNA long interspersed sequence one

1986 • 147 citations

mRNA retroposition in human cells: processed pseudogene formation.

1995 • 146 citations

Mutation Detection in the and Alleles of the Sodium Channel

1996 • 143 citations

Retrotransposition of a mouse IAP sequence tagged with an indicator gene

1991 • 141 citations

A sequence downstream of A-A-U-A-A-A is required for formation of simian virus 40 late mRNA 3' termini in frog oocytes.

1985 • 139 citations

The site-specific ribosomal insertion element type II of Bombyx mori (R2Bm) contains the coding sequence for a reverse transcriptase-like enzyme.

1987 • 134 citations

The LINE-1 DNA sequences in four mammalian orders predict proteins that conserve homologies to retrovirus proteins

1987 • 132 citations

RNA-mediated recombination in S. cerevisiae

1991 • 132 citations

"Retroposon" insertion into the cellular oncogene c-myc in canine transmissible venereal tumor.

1985 • 128 citations

Mobile Group II Introns of Yeast Mitochondrial DNA Are Novel Site-Specific Retroelements

1995 • 123 citations

Translation of LINE-1 DNA elements in vitro and in human cells.

1990 • 123 citations

Mechanism of Transduction by Retroviruses

1992 • 122 citations

Studies on p40, the leucine zipper motif-containing protein encoded by the first open reading frame of an active human LINE-1 transposable element.

1992 • 115 citations

Identification of an internal cis-element essential for the human Li transcription and a nuclear factor(s) binding to the element

1992 • 110 citations

Dysfunction of the Orleans reeler gene arising from exon skipping due to transposition of a full-length copy of an active L1 sequence into the skipped exon

1996 • 99 citations

An indicator gene for detection of germline retrotransposition in transgenic Drosophila demonstrates RNA-mediated transposition of the LINE I element.

1991 • 97 citations

An in vivo assay for the reverse transcriptase of human retrotransposon L1 in Saccharomyces cerevisiae.

1994 • 93 citations

Evidence for retrotransposition of the I factor, a LINE element of Drosophila melanogaster.

1991 • 91 citations

An indicator gene to demonstrate intracellular transposition of defective retroviruses.

1988 • 91 citations

LINE-1: a human transposable element

1993 • 69 citations

Characterization of a nondeleterious L1 insertion in an intron of the human factor VIII gene and further evidence of open reading frames in functional L1 elements

1989 • 69 citations

Generation of processed pseudogenes in murine cells.

1993 • 67 citations

Identification, Characterization, and Cell Specificity of a Human LINE-1 Promoter

1990 • 65 citations

A modified indicator gene for selection of retrotransposition events in mammalian cells.

1994 • 63 citations

Retrotransposition of a mouse L1 element.

1991 • 52 citations

RNA polymerase III dependence of the human L1 promoter and possible participation of the RNA polymerase II factor YY1 in the RNA polymerase III transcription system

1995 • 51 citations

The Structure of the Guanine-rich Polypurine: Polypyrimidine Sequence at the Right End of the Rat L1 (LINE) Element

1989 • 34 citations

Retrotransposition mechanisms

1991 • 34 citations

An Expanding Universe of Introns

1993 • 31 citations

Long interspersed L1 repeats in rabbit DNA are homologous to L1 repeats of rodents and primates in an open-reading-frame region.

1986 • 20 citations

Unusual long target duplication by insertion of intracisternal A‐particle element in radiation‐induced acute myeloid leukemia cells in mouse

1995 • 14 citations

Retransposition of the Drosophilia LINE I Element Can Induce Deletion in the Target DNA: A Simple Model Also Accounting for the Variability of the Normally Observed Target Site Duplications

1994 • 12 citations

Complex patterns of transcription of a Drosophila retrotransposonin vivoand in vitro by RNA polymerases II and III

1995 • 6 citations