Calcium and calmodulin in the control of cellular behavior and motility

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Ionic channels of excitable membranes

1985 • 7,199 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.

1982 • 2,255 citations

New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures

1980 • 2,218 citations

INTRACELLULAR CALCIUM HOMEOSTASIS

1987 • 2,183 citations

Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,458 citations

Carp Muscle Calcium-binding Protein

1973 • 1,359 citations

Impaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,336 citations

Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTP

1989 • 1,335 citations

Ionic Channels of Excitable Membranes, 2nd Ed.

1992 • 1,283 citations

Solution structure of a calmodulin-target peptide complex by multidimensional NMR

1992 • 1,258 citations

A non-disruptive technique for loading calcium buffers and indicators into cells

1981 • 1,121 citations

Three-dimensional structure of calmodulin

1985 • 1,035 citations

Target Enzyme Recognition by Calmodulin: 2.4 Å Structure of a Calmodulin-Peptide Complex

1992 • 1,031 citations

Structure of calmodulin refined at 2.2 Å resolution

1988 • 1,019 citations

An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation

1989 • 1,015 citations

CRYSTAL STRUCTURES OF THE HELIX-LOOP-HELIX CALCIUM-BINDING PROTEINS

1989 • 855 citations

How calmodulin binds its targets: sequence independent recognition of amphiphilic α-helices

1990 • 839 citations

MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium–calmodulin

1992 • 728 citations

Changes of free calcium levels with stages of the cell division cycle

1985 • 591 citations

Loss of calcium/calmodulin responsiveness in adenylate cyclase of rutabaga, a Drosophila learning mutant

1984 • 589 citations

Calcium Entry Leads to Inactivation of Calcium Channel in Paramecium

1978 • 532 citations

Calcium-induced exposure of a hydrophobic surface on calmodulin

1980 • 520 citations

Calcium‐dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin

1990 • 507 citations

The Ca2+-pumping ATPase of heart sarcolemma. Characterization, calmodulin dependence, and partial purification.

1981 • 473 citations

Reactivated Triton-Extracted Models of Paramecium : Modification of Ciliary Movement by Calcium Ions

1972 • 443 citations

Refinement of the structure of carp muscle calcium-binding parvalbumin by model building and difference fourier analysis

1975 • 433 citations

Calcium and cell cycle control

1990 • 432 citations

Fura-2 measurement of cytosolic free Ca2+ in monolayers and suspensions of various types of animal cells.

1987 • 424 citations

Calmodulin and the cell cycle: Involvement in regulation of cell-cycle progression

1982 • 414 citations

Isolation of the yeast calmodulin gene: Calmodulin is an essential protein

1986 • 400 citations

Cyclic Adenosine 3′,5′ Monophosphate, Calcium and Protein Phosphorylation in Flagellar Motility

1983 • 391 citations

Hydrophobic regions function in calmodulin-enzyme(s) interactions.

1980 • 363 citations

Submicromolar levels of calcium control the balance of beating between the two flagella in demembranated models of Chlamydomonas.

1984 • 352 citations

Identification of the major Mr 100,000 substrate for calmodulin-dependent protein kinase III in mammalian cells as elongation factor-2.

1987 • 339 citations

Myosin I is located at the leading edges of locomoting Dictyostelium amoebae

1989 • 323 citations

Can calmodulin function without binding calcium?

1991 • 318 citations

Calcium control of waveform in isolated flagellar axonemes of chlamydomonas

1980 • 309 citations

The Role of Actin Polymerization in Cell Motility

1991 • 301 citations

Interaction of calcium and calmodulin in the presence of sodium dodecyl sulfate

1980 • 273 citations

Calcium-induced asymmetrical beating of triton-demembranated sea urchin sperm flagella.

1979 • 272 citations

Transient increases in cytosolic free calcium appear to be required for the migration of adherent human neutrophils [published erratum appears in J Cell Biol 1990 Mar;110(3):861]

1990 • 265 citations

Multiple elevations of cytosolic-free Ca2+ in human neutrophils: initiation by adherence receptors of the integrin family.

1991 • 259 citations

Calcium-dependent regulator of NAD kinase in higher plants

1978 • 254 citations

Regulation of Protein Phosphorylation and Motility of Sperm by Cyclic Adenosine Monophosphate and Calcium

1982 • 253 citations

The central helix of calmodulin functions as a flexible tether.

1988 • 245 citations

Phosphorylation-regulated calmodulin binding to a prominent cellular substrate for protein kinase C

1989 • 241 citations

The interaction of calmodulin with amphiphilic peptides.

1985 • 239 citations

Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules.

1989 • 218 citations

Ca2+ binding and conformational change in two series of point mutations to the individual Ca(2+)-binding sites of calmodulin.

1992 • 213 citations

Purification and characterization of Ca2+/calmodulin-dependent protein kinase I from bovine brain.

1987 • 212 citations

Inhibition of Neutrophil Chemokinesis on Vitronectin by Inhibitors of Calcineurin

1992 • 200 citations

Agonist and antagonist properties of calmodulin fragments.

1984 • 198 citations

The Protein Phosphatases Involved in Cellular Regulation. 5. Purification and Properties of a Ca2+ /Calmodulin-Dependent Protein Phosphatase (2B) from Rabbit Skeletal Muscle

1983 • 186 citations

Calmodulin dissociation regulates brush border myosin I (110-kD-calmodulin) mechanochemical activity in vitro.

1990 • 184 citations

Calcium/Calmodulin-Dependent Protein Kinase II

1990 • 182 citations

Patterns of elevated free calcium and calmodulin activation in living cells

1992 • 177 citations

Calmodulin confers calcium sensitivity on secretory exocytosis

1982 • 155 citations

Purification of calmodulin from Chlamydomonas: calmodulin occurs in cell bodies and flagella.

1980 • 136 citations

Multifunctional Ca2+/calmodulin-dependent protein kinase: domain structure and regulation

1989 • 136 citations

Identification and properties of cyclic nucleotide phosphodiesterases

1982 • 135 citations

Calmodulin and cell proliferation

1982 • 134 citations

[22] Isolation and characterization of bovine brain calcineurin: A calmodulin-stimulated protein phosphatase

1983 • 133 citations

Characterization and expression of the unique calmodulin gene of Aspergillus nidulans.

1990 • 133 citations

Cortical alveoli of Paramecium: a vast submembranous calcium storage compartment.

1991 • 133 citations

Contractile basis of ameboid movement. VII. Aequorin luminescence during ameboid movement, endocytosis, and capping.

1980 • 133 citations

Mutations in paramecium calmodulin indicate functional differences between the C-terminal and N-terminal lobes in vivo

1990 • 132 citations

Structural apparatus for force transmission in smooth muscles

1984 • 128 citations

Phosphorylation-dependent binding of a synthetic MARCKS peptide to calmodulin.

1991 • 126 citations

Calcium-dependent and calcium-independent exocytosis

1989 • 124 citations

Trimethyllysine and protein function. Effect of methylation and mutagenesis of lysine 115 of calmodulin on NAD kinase activation.

1986 • 120 citations

Quantitation of energy coupling between Ca2+, calmodulin, skeletal muscle myosin light chain kinase, and kinase substrates.

1984 • 120 citations

Changes in the structure of calmodulin induced by a peptide based on the calmodulin-binding domain of myosin light chain kinase

1989 • 118 citations

Attachment to fibronectin or vitronectin makes human neutrophil migration sensitive to alterations in cytosolic free calcium concentration.

1991 • 113 citations

Recycling of cold-stable microtubules: evidence that cold stability is due to substoichiometric polymer blocks

1982 • 112 citations

Differential localization of Acanthamoeba myosin I isoforms.

1992 • 110 citations

A bacterial calcium-binding protein homologous to calmodulin

1987 • 108 citations

Calmodulin confers calcium sensitivity on ciliary dynein ATPase.

1980 • 105 citations

Restoration of the calcium binding activity of mutant calmodulins toward normal by the presence of a calmodulin binding structure

1991 • 103 citations

Calmodulin, cell growth and gene expression

1989 • 102 citations

The dynamic distribution of fluorescent analogues of actin and myosin in protrusions at the leading edge of migrating Swiss 3T3 fibroblasts.

1988 • 101 citations

The insulin receptor and calmodulin. Calmodulin enhances insulin-mediated receptor kinase activity and insulin stimulates phosphorylation of calmodulin.

1986 • 101 citations

Restoration by Calmodulin of a Ca ²⁺ -Dependent K ⁺ Current Missing in a Mutant of Paramecium

1986 • 100 citations

Polycation‐dependent, Ca²⁺‐antagonized phosphorylation of calmodulin by casein kinase‐2 and a spleen tyrosine protein kinase

1987 • 98 citations

Calcium control of ciliary arrest in mussel gill cells.

1978 • 96 citations

Modulation of the asymmetry of sea urchin sperm flagellar bending by calmodulin.

1985 • 95 citations

Ca2(+)-dependent regulation of the spectrin/actin interaction by calmodulin and protein 4.1.

1991 • 93 citations

Native Tropomyosin-like Action of Troponin on Trypsin-treated Myosin B*

1966 • 92 citations

Calcium/calmodulin transduces thrombin-stimulated secretion: studies in intact and minimally permeabilized human umbilical vein endothelial cells.

1992 • 86 citations

A Quantitative Study of the Ca2+/Calmodulin Sensitivity of Adenylyl Cyclase in Aplysia, Drosophila, and Rat

1992 • 85 citations

Calmodulin-dependents stimulation of the NADPH oxidase of human neutrophils

1982 • 75 citations

Insulin-stimulated phosphorylation of calmodulin by rat liver insulin receptor preparations.

1988 • 75 citations

Amino acid sequence of a novel calmodulin from Paramecium tetraurelia that contains dimethyllysine in the first domain.

1987 • 72 citations

Ca-Induced K+-Outward Current in Paramecium Tetraurelia

1980 • 72 citations

An Anticalmodulin Drug, W-7, Inhibits the Voltage-Dependent Calcium Current in Paramecium Caudatum

1984 • 70 citations

Insulin stimulates the phosphorylation of calmodulin in intact adipocytes.

1987 • 70 citations

Calmodulin Activation of Calcium-Dependent Sodium Channels in Excised Membrane Patches of Paramecium

1990 • 69 citations

Kinetic studies show that calcium and terbium have different binding preferences toward the four calcium-binding sites of calmodulin

1984 • 68 citations

Rabbit skeletal muscle phosphorylase kinase. Catalytic and regulatory properties of the active alpha gamma delta and gamma delta complexes.

1982 • 67 citations

Ca2+ stimulates the Mg2(+)-ATPase activity of brush border myosin I with three or four calmodulin light chains but inhibits with less than two bound.

1991 • 67 citations

Stopped‐flow studies of calcium dissociation from calcium‐binding‐site mutants of Drosophila melanogaster calmodulin

1992 • 66 citations

The design, synthesis, and characterization of tight‐binding inhibitors of calmodulin

1985 • 66 citations

Calcium As an Intracellular Messenger in Eucaryotic Microbes

1990 • 66 citations

A Magnesium Current in Paramecium

1990 • 64 citations

Calmodulin Mutants and Ca2+ -Dependent Channels in Paramecium

1991 • 59 citations

Cellular Calcium Metabolism

1983 • 58 citations

Function of calmodulin in mammalian sperm: Presence of a calmodulin-dependent cyclic nucleotide phosphodiesterase associated with demembranated rat caudal epididymal sperm

1984 • 58 citations

Calcium-dependent sodium currents inParamecium: Mutational manipulations and effects of hyper- and depolarization

1986 • 57 citations

Calcium-calmodulin regulated effectors of microtubule stability in bovine brain

1992 • 57 citations

Use of engineered proteins with internal tryptophan reporter groups and perturbation techniques to probe the mechanism of ligand-protein interactions: investigation of the mechanism of calcium binding to calmodulin

1992 • 57 citations

Selective effects of CAPP1-calmodulin on its target proteins

1985 • 56 citations

Phosphorylation by casein kinase II alters the biological activity of calmodulin

1992 • 55 citations

Calcium/calmodulin‐regulated guanylate cyclase and calcium‐permeability in the ciliary membrane from Tetrahymena

1983 • 55 citations

Paramecium: a model system for the study of excitable cells

1988 • 53 citations

Isolation of an immunoreactive analogue of brain fodrin that is associated with the cell cortex of Dictyostelium amoebae

1988 • 52 citations

Insulin-stimulated phosphorylation of calmodulin

1992 • 51 citations

Calcium dependence of ciliary activity in the oviduct of the salamander Necturus

1972 • 51 citations

A potassium conductance activated by hyperpolarization in paramecium

1978 • 49 citations

THE CALCIUM‐TRANSPORTING ATPase OF ERYTHROCYTES*

1982 • 47 citations

A galactose-dependent cmd1 mutant of Saccharomyces cerevisiae: involvement of calmodulin in nuclear division

1989 • 47 citations

Effects of calmodulin antagonists on calcium‐activated potassium channels in pregnant rat myometrium

1990 • 46 citations

How Animal Cells Move

1987 • 46 citations

Calcium receptor protein calmodulin isolated from cilia and cells of Paramecium tetraurelia.

1981 • 45 citations

Specific localization of scallop gill epithelial calmodulin in cilia

1982 • 45 citations

A calcium-sensitive fluorescent analog of calmodulin based on a novel calmodulin-binding fluorophore

1990 • 44 citations

Calcium-induced Shape Change of Calmodulin with Mastoparan Studied by Solution X-ray Scattering

1989 • 42 citations

Chemosensory Transduction in Eukaryotic Microorganisms

1992 • 39 citations

Evidence for two K+ currents activated upon hyperpolarization ofParamecium tetraurelia

1990 • 38 citations

Purification of Ca²⁺‐activated K⁺ channel protein on calmodulin affinity columns after detergent solubilization of luminal membranes from outer renal medulla

1987 • 35 citations

GENETIC ANALYSIS OF MUTANTS WITH A REDUCED Ca2+-DEPENDENT K+ CURRENT IN PARAMECIUM TETRAURELIA

1985 • 34 citations

Strongylocentrotus purpuratus spindle tubulin. II. Characteristics of its sensitivity to Ca++ and the effects of calmodulin isolated from bovine brain and S. purpuratus eggs.

1982 • 34 citations

Calmodulin defects cause the loss of Ca2+-dependent K+ currents in two pantophobiac mutants ofParamecium tetraurelia

1990 • 34 citations

Identification and Characterization of Calmodulin-binding Proteins in Mammalian Sperm Flagella

1989 • 31 citations

Greater importance of Ca2+-calmodulin in maintenance of ang II-and K+-mediated aldosterone secretion: Lesser role of protein kinase C

1992 • 31 citations

Expression of the H-ras oncogene induces potassium conductance and neuron-specific potassium channel mRNAs in the AtT20 cell line

1992 • 30 citations

The calmodulin-binding domain on microtubule-associated protein 2.

1984 • 30 citations

GENETIC ANALYSES OF "PARANOIAC" MUTANTS OF PARAMECIUM TETRAURELIA

1977 • 29 citations

Sliding of stable tubule only polypeptide proteins on microtubules

1984 • 28 citations

Genetic dissection of Ca²⁺‐dependent ion channel function in Paramecium

1990 • 27 citations

Genetic Alteration of Proteins in Actin-Based Motility Systems

1991 • 26 citations

Calmodulin levels in the yeast and mycelial phases of Ceratocystis ulmi

1985 • 24 citations

Calcium and Cyclic AMP as Synarchic Messengers

1982 • 24 citations

A mutation that increases a novel calcium-activated potassium conductance ofParamecium tetraurelia

1986 • 24 citations

Mutational analysis of calmodulin in Saccharomyces cerevisiae

1992 • 23 citations

Inhibition of Acanthamoeba myosin I heavy chain kinase by Ca(2+)-calmodulin.

1992 • 22 citations

Biochemical characterization of a genetically altered calmodulin in Paramecium

1987 • 22 citations

Calmodulin is involved in catecholamine secretion from digitonin-permeabilized bovine adrenal medullary chromaffin cells

1992 • 22 citations

Mode of activation of bovine brain inositol 1,4,5-trisphosphate 3-kinase by calmodulin and calcium

1989 • 21 citations

Inhibition of lung metastasis by a calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), in mice bearing Lewis lung carcinoma.

1991 • 20 citations

Yeast calmodulin: Structural and functional elements essential for the cell cycle

1992 • 18 citations

Analysis of the molecular basis of calmodulin defects that affect ion channel-mediated cellular responses: site-specific mutagenesis and microinjection.

1990 • 18 citations

Evidence against insulin-stimulated phosphorylation of calmodulin in 3T3-L1 adipocytes

1989 • 18 citations

The cilia of Paramecium tetraurelia contain both Ca2+-dependent and Ca2+-inhibitable calmodulin-binding proteins

1989 • 15 citations

The Integration of Receptor-Regulated Intracellular Calcium Release and Calcium Entry across the Plasma Membrane

1990 • 15 citations

Lithium fluxes in Paramecium and their relationship to chemoresponse

1992 • 15 citations

The role of calmodulin on Ca2+-dependent K+ transport regulation in the human red cell

1986 • 14 citations

An intragenic suppressor of a calmodulin mutation in Paramecium: genetic and biochemical characterization.

1991 • 13 citations

Cell cycle dependent variation of calmodulin in Tetrahymena.

1988 • 10 citations

Cell cycle-dependent regulation of calmodulin levels in Saccharomyces cerevisiae.

1989 • 8 citations

Calmodulin-Binding Proteins in the Cytosol Extract of Sea Urchin Eggs1

1983 • 8 citations

A New Protein Factor that Modulates Assembly of Microtubules In Vitro1

1980 • 7 citations

Target molecules of calmodulin on microtubules of Tetrahymena cilia

1988 • 6 citations

Casein kinase II-catalysed phosphorylation of calmodulin is altered by amino acid deletions in the central helix of calmodulin

1992 • 6 citations

Conformational properties of Ca2+-binding segments of proteins from the troponin C superfamily

1988 • 5 citations

Effect of calcium-modifying agents on the growth of human gastric carcinoma cells in vitro.

1992 • 3 citations

Coated vesicles purified from chick tendon fibroblasts contain newly synthesized type I procollagen

1985 • 1 citations