Back to search

The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells

Data up to Jan 2025

Published2007
Citations127
References42

Total Citations Per Year

Abstract

References (42)

Angiogenesis in cancer and other diseases

2000 • 8,734 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Fibroblasts in cancer

2006 • 4,177 citations

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

2005 • 3,543 citations

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

2000 • 2,700 citations

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

1989 • 2,267 citations

Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.

1993 • 1,391 citations

Molecular and biological properties of vascular endothelial growth factor

1999 • 1,174 citations

Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy

2006 • 1,157 citations

Tumor Induction of VEGF Promoter Activity in Stromal Cells

1998 • 964 citations

Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

1999 • 937 citations

Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors.

1992 • 900 citations

Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors

2005 • 687 citations

Corneal avascularity is due to soluble VEGF receptor-1

2006 • 649 citations

The Carboxyl-terminal Domain(111–165) of Vascular Endothelial Growth Factor Is Critical for Its Mitogenic Potency

1996 • 615 citations

An amino-bisphosphonate targets MMP-9–expressing macrophages and angiogenesis to impair cervical carcinogenesis

2004 • 597 citations

The Connective Tissue Growth Factor/Cysteine- Rich 61/Nephroblastoma Overexpressed (CCN) Family*

1999 • 567 citations

An amino-bisphosphonate targets MMP-9–expressing macrophages and angiogenesis to impair cervical carcinogenesis

2004 • 559 citations

Role of Matrix Metalloproteinase-7 (Matrilysin) in Human Cancer Invasion, Apoptosis, Growth, and Angiogenesis

2006 • 430 citations

Matrix metalloproteinases in repair

1999 • 375 citations

The Connective Tissue Growth Factor/Cysteine- Rich 61/Nephroblastoma Overexpressed (CCN) Family

1999 • 368 citations

Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF‐induced angiogenesis

2001 • 360 citations

Matrix Metalloproteinases Cleave Connective Tissue Growth Factor and Reactivate Angiogenic Activity of Vascular Endothelial Growth Factor 165

2002 • 348 citations

VEGF-null cells require PDGFR α signaling-mediated stromal fibroblast recruitment for tumorigenesis

2004 • 287 citations

ADAMTS1/METH1 Inhibits Endothelial Cell Proliferation by Direct Binding and Sequestration of VEGF165

2003 • 255 citations

Novel Vascular Endothelial Growth Factor Binding Domains of Fibronectin Enhance Vascular Endothelial Growth Factor Biological Activity

2002 • 241 citations

Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas

2002 • 222 citations

Platelet Factor-4 Inhibits the Mitogenic Activity of VEGF121 and VEGF165 Using Several Concurrent Mechanisms

1995 • 203 citations

Purification and Characterization of Novel Heparin-binding Growth Factors in Uterine Secretory Fluids

1997 • 202 citations

Making the cut: Protease-mediated regulation of angiogenesis

2006 • 190 citations

Mammary fibroblasts may influence breast tumor angiogenesis via hypoxia-induced vascular endothelial growth factor up-regulation and protein expression.

1994 • 185 citations

Expression of von Willebrand factor, an endothelial cell marker, is up-regulated by angiogenesis factors: A potential method for objective assessment of tumor angiogenesis

2000 • 168 citations

CCN2 (Connective Tissue Growth Factor) Promotes Fibroblast Adhesion to Fibronectin

2004 • 165 citations

The Contribution of Bone Marrow–Derived Cells to the Tumor Vasculature in Neuroblastoma Is Matrix Metalloproteinase-9 Dependent

2005 • 155 citations

Binding and displacement of vascular endothelial growth factor (VEGF) by thrombospondin: effect on human microvascular endothelial cell proliferation and angiogenesis.

1999 • 148 citations

Expression of von Willebrand factor, an endothelial cell marker, is up-regulated by angiogenesis factors: A potential method for objective assessment of tumor angiogenesis

2000 • 128 citations

Antiangiogenesis drug promising for metastatic colorectal cancer

2003 • 95 citations

MMP-7 (matrilysin) accelerated growth of human umbilical vein endothelial cells

2002 • 78 citations

Matrilysin (MMP-7) degrades VE-cadherin and accelerates accumulation of beta-catenin in the nucleus of human umbilical vein endothelial cells

2006 • 59 citations

A Novel ex Vivo Angiogenesis Assay Based on Electroporation-Mediated Delivery of Naked Plasmid DNA to Skeletal Muscle

2004 • 49 citations

In vivo and in vitro characterization of human fibroblasts recruited selectively into human cancer stroma

2005 • 43 citations

Cited By (0)

Loading...
The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells (2007) – Oncogene | Metascience Observatory Explorer