ADAMTS1/METH1 Inhibits Endothelial Cell Proliferation by Direct Binding and Sequestration of VEGF165

New functions for the matrix metalloproteinases in cancer progression

2002 • 5,937 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Vascular endothelial growth factor (VEGF) and its receptors

1999 • 3,498 citations

Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

2002 • 2,711 citations

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

2000 • 2,700 citations

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

1989 • 2,267 citations

VEGF and the quest for tumour angiogenesis factors

2002 • 1,467 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.

1993 • 1,114 citations

Role of vascular endothelial growth factor in regulation of physiological angiogenesis

2001 • 1,068 citations

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.

1987 • 1,045 citations

SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types.

1999 • 1,044 citations

Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1

2000 • 992 citations

The splice variants of vascular endothelial growth factor (VEGF) and their receptors

2001 • 943 citations

Growth factors in the extracellular matrix

1997 • 879 citations

Regulation of angiogenesis via vascular endothelial growth factor receptors.

2000 • 749 citations

Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors.

1999 • 660 citations

Matrix metalloproteinases in cancer: Prognostic markers and therapeutic targets

2002 • 635 citations

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer

1995 • 622 citations

SPARC, a matricellular protein: at the crossroads of cell–matrix communication

2001 • 566 citations

Thrombospondin‐1 as an endogenous inhibitor of angiogenesis and tumor growth

2002 • 534 citations

Structure and Function of VEGF/VEGF-receptor System Involved in Angiogenesis.

2001 • 508 citations

Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels.

1991 • 495 citations

Molecular Cloning of a Gene Encoding a New Type of Metalloproteinase-disintegrin Family Protein with Thrombospondin Motifs as an Inflammation Associated Gene

1997 • 480 citations

Complex roles of tissue inhibitors of metalloproteinases in cancer

2002 • 472 citations

Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor

2001 • 463 citations

The functions of thrombospondin-1 and-2

2000 • 435 citations

METH-1, a Human Ortholog of ADAMTS-1, and METH-2 Are Members of a New Family of Proteins with Angio-inhibitory Activity

1999 • 420 citations

Endostatin Blocks Vascular Endothelial Growth Factor-mediated Signaling via Direct Interaction with KDR/Flk-1

2002 • 420 citations

Vascular endothelial growth factor binds to fibrinogen and fibrin and stimulates endothelial cell proliferation

2000 • 399 citations

Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF‐induced angiogenesis

2001 • 360 citations

ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function

2000 • 305 citations

Vascular Endothelial Growth Factor Effect on Endothelial Cell Proliferation, Migration, and Platelet-activating Factor Synthesis Is Flk-1-dependent

1999 • 299 citations

Activated Conformations of Very Late Activation Integrins Detected by a Group of Antibodies (HUTS) Specific for a Novel Regulatory Region(355-425) of the Common β1 Chain

1996 • 298 citations

Transforming growth factor-beta complexes with thrombospondin.

1992 • 256 citations

The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta.

1994 • 250 citations

Novel Vascular Endothelial Growth Factor Binding Domains of Fibronectin Enhance Vascular Endothelial Growth Factor Biological Activity

2002 • 241 citations

ADAMTS-1 Protein Anchors at the Extracellular Matrix through the Thrombospondin Type I Motifs and Its Spacing Region

1998 • 225 citations

Selective Binding of VEGF121 to One of the Three Vascular Endothelial Growth Factor Receptors of Vascular Endothelial Cells

1996 • 200 citations

Glypican-1 Is a VEGF165 Binding Proteoglycan That Acts as an Extracellular Chaperone for VEGF165

1999 • 182 citations

Integrin signaling: it's where the action is

2002 • 173 citations

ADAMTS-1 Is an Active Metalloproteinase Associated with the Extracellular Matrix

1999 • 154 citations

Binding and displacement of vascular endothelial growth factor (VEGF) by thrombospondin: effect on human microvascular endothelial cell proliferation and angiogenesis.

1999 • 148 citations

Characterization of METH-1/ADAMTS1 Processing Reveals Two Distinct Active Forms

2000 • 145 citations

Interaction of vasculotropin/vascular endothelial cell growth factor with human umbilical vein endothelial cells: Binding, internalization, degradation, and biological effects

1991 • 128 citations

Vascular endothelial growth factor is inactivated by binding to alpha 2-macroglobulin and the binding is inhibited by heparin.

1993 • 122 citations

Endothelial cells exhibiting angiogenesis in vitro proliferate in response to TGF‐β1

1993 • 108 citations

Further characterization of malignant glioma-derived vascular permeability factor

1988 • 107 citations

Inhibition of vascular endothelial growth factor-induced receptor activation with anti-kinase insert domain-containing receptor single-chain antibodies from a phage display library.

1998 • 105 citations

Variation in Detection of VEGF in Maternal Serum by Immunoassay and the Possible Influence of Binding Proteins

1997 • 102 citations

The 140-kilodalton antiangiogenic fragment of thrombospondin-1 binds to basic fibroblast growth factor.

1997 • 99 citations

Vascular Endothelial Growth Factor: Acting as an Autocrine Growth Factor for Human Gastric Adenocarcinoma Cell MGC803

2001 • 81 citations

Extracellular matrix tenascin‐X in combination with vascular endothelial growth factor B enhances endothelial cell proliferation

2000 • 74 citations

VEGF165 requires extracellular matrix components to induce mitogenic effects and migratory response in breast cancer cells

2001 • 60 citations

Vascular endothelial growth factor is bound in amniotic fluid and maternal serum

1999 • 57 citations

Interaction of platelet-derived growth factor with thrombospondin 1

1997 • 56 citations

Vascularization of human glioma spheroids implanted into rat cortex is conferred by two distinct mechanisms

1999 • 43 citations

Oxidative stress due to hypoxia/reoxygenation induces angiogenic factor VEGF in adult rat myocardium: possible role of NFκB

2000 • 35 citations

Depletion of [Ca2+]i Inhibits Hypoxia-Induced Vascular Permeability Factor (Vascular Endothelial Growth Factor) Gene Expression

1996 • 26 citations

The basic residues of placenta growth factor type 2 retrieve sequestered angiogenic factors into a soluble form: implications for tumor angiogenesis.

1998 • 24 citations