Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts

CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors

1997 • 2,201 citations

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

Chk1 is an essential kinase that is regulated by Atr and required for the G₂/M DNA damage checkpoint

2000 • 1,583 citations

Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

1998 • 1,314 citations

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

1997 • 1,285 citations

Chapter 30 Cell Cycle Extracts

1991 • 953 citations

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

2000 • 922 citations

Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

1999 • 801 citations

Protein–protein interactions define specificity in signal transduction

2000 • 757 citations

Regulation of RAD53 by the ATM -Like Kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways

1996 • 593 citations

Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

1999 • 580 citations

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

2000 • 425 citations

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

2000 • 412 citations

rad -Dependent Response of the chk1 -Encoded Protein Kinase at the DNA Damage Checkpoint

1996 • 397 citations

Rad53 FHA Domain Associated with Phosphorylated Rad9 in the DNA Damage Checkpoint

1998 • 392 citations

The Xenopus Cdc6 Protein Is Essential for the Initiation of a Single Round of DNA Replication in Cell-Free Extracts

1996 • 387 citations

S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe

1998 • 386 citations

The G2-phase DNA-damage checkpoint

2000 • 365 citations

Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: Studies in Xenopus

1990 • 354 citations

Cell cycle regulation of a Xenopus Wee1-like kinase.

1995 • 316 citations

Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25

1999 • 304 citations

Cell cycle checkpoints

1994 • 284 citations

A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage

1999 • 265 citations

Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1

1997 • 247 citations

The Xenopus Chk1 Protein Kinase Mediates a Caffeine-sensitive Pathway of Checkpoint Control in Cell-free Extracts

1998 • 244 citations

Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import

1999 • 236 citations

Cell Cycle Regulation of the Replication Licensing System: Involvement of a Cdk-dependent Inhibitor

1997 • 166 citations

DNA damage checkpoint in budding yeast

1998 • 162 citations

DNA Damage and Replication Checkpoints in Fission Yeast Require Nuclear Exclusion of the Cdc25 Phosphatase via 14-3-3 Binding

1999 • 161 citations

RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation

1998 • 153 citations

Control of the Cdc2/cyclin B complex in Xenopus egg extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors.

1995 • 123 citations

Isolation and characterization of the Schizosaccharomyces pombe rhp9 gene: a gene required for the DNA damage checkpoint but not the replication checkpoint

1997 • 100 citations

Protein phosphatase 2A is required for the initiation of chromosomal DNA replication

1998 • 90 citations

Response ofXenopusCds1 in Cell-free Extracts to DNA Templates with Double-stranded Ends

2000 • 86 citations

Exercising self-restraint: Discouraging illicit acts of S and M in eukaryotes

1993 • 83 citations

A novel protein phosphatase inhibitor, tautomycin Effect on smooth muscle

1991 • 71 citations