Checkpoint adaptation in human cells

Radiobiology for the Radiologist.

1974 • 3,582 citations

Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

1998 • 2,784 citations

Cell-cycle checkpoints and cancer

2004 • 2,699 citations

Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses

2003 • 1,594 citations

Radiobiology for the Radiologist

1995 • 1,349 citations

Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

1998 • 1,314 citations

Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle

2003 • 1,157 citations

The role of apoptosis in cancer development and treatment response

2005 • 921 citations

Loss of a yeast telomere: Arrest, recovery, and chromosome loss

1993 • 787 citations

Saccharomyces Ku70, Mre11/Rad50, and RPA Proteins Regulate Adaptation to G2/M Arrest after DNA Damage

1998 • 773 citations

Surviving the Breakup: The DNA Damage Checkpoint

2006 • 549 citations

Radiation-induced apoptosis: Relevance to radiotherapy

1995 • 504 citations

Specialized DNA Polymerases, Cellular Survival, and the Genesis of Mutations

2002 • 441 citations

CDC5 and CKII Control Adaptation to the Yeast DNA Damage Checkpoint

1997 • 433 citations

Control of mitosis by changes in the subcellular location of cyclin-B1–Cdk1 and Cdc25C

2000 • 384 citations

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

2005 • 372 citations

Polo-like Kinase-1 Controls Recovery from a G2 DNA Damage-Induced Arrest in Mammalian Cells

2004 • 361 citations

Cell Apoptosis: Requirement of H2AX in DNA Ladder Formation, but Not for the Activation of Caspase-3

2006 • 334 citations

Centrosome-associated Chk1 prevents premature activation of cyclin-B–Cdk1 kinase

2004 • 334 citations

How does radiation kill cells?

1999 • 313 citations

Regulation of Saccharomyces Rad53 Checkpoint Kinase during Adaptation from DNA Damage–Induced G2/M Arrest

2001 • 287 citations

SCFβTrCP-Mediated Degradation of Claspin Regulates Recovery from the DNA Replication Checkpoint Response

2006 • 280 citations

Human Cyclin a Is Required for Mitosis until Mid Prophase

1999 • 256 citations

Destruction of Claspin by SCFβTrCP Restrains Chk1 Activation and Facilitates Recovery from Genotoxic Stress

2006 • 246 citations

Adaptation of a DNA Replication Checkpoint Response Depends upon Inactivation of Claspin by the Polo-like Kinase

2004 • 220 citations

Polo-like Kinase-1 Controls Proteasome-Dependent Degradation of Claspin during Checkpoint Recovery

2006 • 217 citations

PP2C Phosphatases Ptc2 and Ptc3 Are Required for DNA Checkpoint Inactivation after a Double-Strand Break

2003 • 199 citations

Chk1 in the DNA damage response: conserved roles from yeasts to mammals

2004 • 192 citations

Proliferation Kinetics of X-irradiated Mouse L Cells Studied with Time-lapse Photography. II

1969 • 182 citations

Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells

2001 • 165 citations

Adaptation to the Ionizing Radiation–Induced G2 Checkpoint Occurs in Human Cells and Depends on Checkpoint Kinase 1 and Polo-like Kinase 1 Kinases

2006 • 159 citations

GFP tagging reveals human Polo-like kinase 1 at the kinetochore/centromere region of mitotic chromosomes

1998 • 145 citations

Centrosomal and Cytoplasmic Cdc2/Cyclin B1 Activation Precedes Nuclear Mitotic Events

2000 • 143 citations

p53 mediates permanent arrest over multiple cell cycles in response to gamma-irradiation.

1997 • 143 citations

Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation

2004 • 138 citations

Phosphorylated histone H2AX in relation to cell survival in tumor cells and xenografts exposed to single and fractionated doses of X-rays

2006 • 117 citations

Spontaneous premature chromosome condensation and mitotic catastrophe following irradiation of HeLa S3 cells

1997 • 110 citations

Structure meets function—Centrosomes, genome maintenance and the DNA damage response

2006 • 110 citations

Checkpoint Adaptation Precedes Spontaneous and Damage-Induced Genomic Instability in Yeast

2001 • 108 citations

Cyclin B1 availability is a rate-limiting component of the radiation-induced G2 delay in HeLa cells.

1997 • 87 citations

The Saccharomyces recombination protein Tid1p is required for adaptation from G2/M arrest induced by a double-strand break

2001 • 77 citations

Phosphorylated Histone H2AX Foci Persist on Rejoined Mitotic Chromosomes in Normal Human Diploid Cells Exposed to Ionizing Radiation

2006 • 77 citations

Restarting the Cell Cycle When the Checkpoint Comes to a Halt

2005 • 60 citations

Yeast Rad52 and Rad51 Recombination Proteins Define a Second Pathway of DNA Damage Assessment in Response to a Single Double-Strand Break

2003 • 58 citations

Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus Egg Extracts Requires Binding of ATRIP to ATR but Not the Stable DNA-binding or Coiled-coil Domains of ATRIP

2005 • 57 citations

Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures

2006 • 54 citations

Computerized Video Time-Lapse Analysis of Apoptosis of REC:Myc Cells X-Irradiated in Different Phases of the Cell Cycle

2000 • 52 citations

Delayed cyclin B1 expression during the G2 arrest following DNA damage.

1996 • 51 citations

γ-H2AX Expression Pattern in Non-Irradiated Neonatal Mouse Germ Cells and after Low-Dose γ-Radiation: Relationships Between Chromatid Breaks and DNA Double-Strand Breaks1

2004 • 50 citations

Effects of Ionizing Radiation on Cyclin Expression in HeLa Cells

1992 • 40 citations

Computerized Video Time-Lapse (CVTL) Analysis of Cell Death Kinetics in Human Bladder Carcinoma Cells (EJ30) X-Irradiated in Different Phases of the Cell Cycle

2002 • 29 citations

The G2 checkpoint activated by DNA damage does not prevent genome instability in plant cells

2006 • 27 citations

Resisting Arrest: Recovery from Checkpoint Arrest Through Dephosphorylation of Chk1 by PP1

2004 • 25 citations