Secretin and vasoactive intestinal peptide receptors: Members of a unique family of G protein–coupled receptors

A G Protein-Linked Receptor for Parathyroid Hormone and Parathyroid Hormone-Related Peptide

1991 • 1,230 citations

Differential signal transduction by five splice variants of the PACAP receptor

1993 • 1,185 citations

The 2.0 Å crystal structure of a heterotrimeric G protein

1996 • 1,118 citations

STRUCTURE AND FUNCTION OF G PROTEIN-COUPLED RECEPTORS

1994 • 1,070 citations

Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.

1992 • 1,009 citations

Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1.

1992 • 880 citations

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1993 • 769 citations

Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide

1992 • 752 citations

Crystal structure of a GA protein βγdimer at 2.1 Å resolution

1996 • 741 citations

Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain

1993 • 536 citations

The VIP₂ receptor: Molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide

1993 • 496 citations

Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain.

1993 • 485 citations

cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells.

1994 • 473 citations

Expression Cloning of an Adenylate Cyclase-Coupled Calcitonin Receptor

1991 • 458 citations

Pituitary adenylate cyclase activating polypeptide (PACAP): discovery and current status of research

1992 • 449 citations

Two receptors for vasoactive intestinal polypeptide with similar specificity and complementary distributions

1994 • 424 citations

Molecular cloning and expression of a cDNA encoding the secretin receptor.

1991 • 415 citations

GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function

1993 • 399 citations

Expression cloning and signaling properties of the rat glucagon receptor

1993 • 393 citations

A cDNA Encoding the Calcitonin Gene-related Peptide Type 1 Receptor

1996 • 319 citations

Tertiary and Quaternary Structural Changes in G _iα1 Induced by GTP Hydrolysis

1995 • 294 citations

Receptors for secretin, calcitonin, parathyroid hormone (PTH)/PTH-related peptide, vasoactive intestinal peptide, glucagonlike peptide 1, growth hormone-releasing hormone, and glucagon belong to a newly discovered G-protein-linked receptor family

1993 • 291 citations

The classification of seven transmembrane receptors in recombinant expression systems.

1996 • 271 citations

MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype.

1995 • 269 citations

Stimulation of nitric oxide from muscle cells by VIP: prejunctional enhancement of VIP release

1992 • 258 citations

A di-leucine motif mediates endocytosis and basolateral sorting of macrophage IgG Fc receptors in MDCK cells.

1994 • 253 citations

Dual pathways of internalization of the cholecystokinin receptor.

1995 • 236 citations

Comparative analysis of mutations in the p53 and K‐ras genes in pancreatic cancer

1994 • 235 citations

Interaction of porcine vasoactive intestinal peptide with dispersed pancreatic acinar cells from the guinea pig. Binding of radioiodinated peptide.

1976 • 214 citations

The origins, pathways and terminations of neurons with VIP-like immunoreactivity in the guinea-pig small intestine

1983 • 211 citations

Interaction of porcine vasoactive intestinal peptide with dispersed pancreatic acinar cells from the guinea pig. Structural requirements for effects of vasoactive intestinal peptide and secretin on cellular adenosine 3':5'-monophosphate.

1976 • 200 citations

Cloning and Functional Expression of a Human Neuroendocrine Vasoactive Intestinal Peptide Receptor

1993 • 192 citations

Identification of a cytoplasmic Ser-Thr-Leu motif that determines agonist-induced internalization of the AT1 angiotensin receptor.

1994 • 186 citations

Vasoactive intestinal polypeptide: specific binding to rat brain membranes.

1979 • 181 citations

Effect of Different G Protein-coupled Receptor Kinases on Phosphorylation and Desensitization of the α1B-Adrenergic Receptor

1996 • 175 citations

Alternative Splicing of the Dopamine D2 Receptor Directs Specificity of Coupling to G-proteins

1995 • 172 citations

Full Activation of Chimeric Receptors by Hybrids between Parathyroid Hormone and Calcitonin

1996 • 170 citations

Critical Contributions of Amino-terminal Extracellular Domains in Agonist Binding and Activation of Secretin and Vasoactive Intestinal Polypeptide Receptors. STUDIES OF CHIMERIC RECEPTORS

1995 • 169 citations

Effect of VIP infusion on water and ion transport in the human jejunum

1980 • 167 citations

Signalling from TPA to MAP kinase requires protein kinase C, raf and MEK: reconstitution of the signalling pathway in vitro.

1994 • 162 citations

A recombinant calcitonin receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+/inositol phosphate signaling pathways.

1992 • 152 citations

Human Intestinal VIP Receptor: Cloning and Functional Expression of Two cDNA Encoding Proteins with Different N-Terminal Domains

1994 • 149 citations

Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation

1997 • 148 citations

Expression cloning of an insect diuretic hormone receptor. A member of the calcitonin/secretin receptor family.

1994 • 146 citations

Transmitter Role of Vasoactive Intestinal Peptide

1993 • 143 citations

In vitro identification of vasoactive intestinal peptide receptors in human tumors: implications for tumor imaging.

1995 • 140 citations

Vasoactive intestinal polypeptide. A neurotransmitter for lower esophageal sphincter relaxation.

1984 • 134 citations

The Cytoplasmic Tail of the G-protein-coupled Receptor for Parathyroid Hormone and Parathyroid Hormone-related Protein Contains Positive and Negative Signals for Endocytosis

1995 • 133 citations

Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit.

1990 • 130 citations

Molecular identification of receptors for vasoactive intestinal peptide in rat intestinal epithelium by covalent cross‐linking

1984 • 130 citations

A vasoactive intestinal peptide antagonist inhibits non-small cell lung cancer growth.

1993 • 130 citations

Evolution of the growth hormone-releasing factor (GRF) family of peptides.

1992 • 123 citations

Vasoactive intestinal peptide: A neurotransmitter for relaxation of the rabbit internal anal sphincter

1985 • 119 citations

Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide-dependent activation of membrane-bound NO synthase in smooth muscle mediated by pertussis toxin-sensitive Gi1-2.

1994 • 112 citations

Amino acid sequences of helospectins, new members of the glucagon superfamily, found in Gila monster venom.

1984 • 105 citations

Gastric inhibitory polypeptide receptor, a member of the secretin- vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain

1993 • 104 citations

Mutagenesis of N-Glycosylation Sites in the Human Vasoactive Intestinal Peptide 1 Receptor. Evidence That Asparagine 58 or 69 Is Crucial for Correct Delivery of the Receptor to Plasma Membrane

1996 • 101 citations

Cloning and Functional Characterization of the Human Vasoactive Intestinal Peptide (VIP)-2 Receptor

1995 • 100 citations

Functionally different isoforms of the human calcitonin receptor result from alternative splicing of the gene transcript.

1995 • 99 citations

Multiple Extracellular Loop Domains Contribute Critical Determinants for Agonist Binding and Activation of the Secretin Receptor

1996 • 97 citations

On the causation of the so-called ‘peripheral reflex secretion’ of the pancreas. (Preliminary communication.)

1902 • 97 citations

Multiple Facets of the Modulation of Growth by cAMP

1995 • 95 citations

Isoforms of the rat calcitonin receptor: consequences for ligand binding and signal transduction.

1994 • 91 citations

Vasoactive intestinal polypeptide (VIP) in the pig pancreas: role of VIPergic nerves in control of fluid and bicarbonate secretion

1984 • 87 citations

Inhibitory transmission in tenia coli mediated by distinct vasoactive intestinal peptide and apamin-sensitive pituitary adenylate cyclase activating peptide receptors.

1994 • 86 citations

Secretin: specific binding to rat brain membranes

1983 • 84 citations

Role of Receptor Phosphorylation in Desensitization and Internalization of the Secretin Receptor

1996 • 83 citations

Secretin activates Cl- channels in bile duct epithelial cells through a cAMP-dependent mechanism

1994 • 82 citations

The C-terminus ends of secretin and VIP interact with the N-terminal domains of their receptors

1996 • 80 citations

Properties of Chimeric Secretin and VIP Receptor Proteins Indicate the Importance of the N-Terminal Domain for Ligand Discrimination

1995 • 79 citations

Secretin stimulates cyclic AMP and inositol trisphosphate production in rat pancreatic acinar tissue by two fully independent mechanisms.

1987 • 78 citations

A ¹H‐NMR study of the solution conformation of secretin resonance assignment and secondary structure

1987 • 78 citations

Vasoactive intestinal peptide increases intracellular calcium in astroglia: synergism with alpha-adrenergic receptors.

1994 • 76 citations

Vasoactive Intestinal Peptide: An Important Trophic Factor and Developmental Regulator?

1995 • 76 citations

Tolerance to lactose among lactase-deficient American Indians

1978 • 74 citations

Mutational Analysis of Cysteine Residues within the Extracellular Domains of the Human Vasoactive Intestinal Peptide (VIP) 1 Receptor Identifies Seven Mutants That Are Defective in VIP Binding

1995 • 74 citations

Intrinsic photoaffinity labeling of native and recombinant rat pancreatic secretin receptors

1993 • 72 citations

Receptors for vasoactive intestinal peptide and secretin on rat pancreatic acini

1984 • 70 citations

The Amino-Terminal Fragment of the Adenylate-Cyclase Activating Polypeptide (Pacap) Receptor Functions as a High-Affinity Pacap Finding Domain

1995 • 70 citations

A recombinant calcitonin receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+/inositol phosphate signaling pathways

1992 • 68 citations

Factors Determining Specificity of Signal Transduction by G-protein-coupled Receptors

1995 • 65 citations

Exendin-3, a novel peptide from Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. Description of exendin-3(9-39) amide, a specific exendin receptor antagonist.

1991 • 64 citations

Role of protein kinase-A in homologous down-regulation of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid in human osteoblast-like SaOS-2 cells.

1994 • 63 citations

Insulation of a G protein-coupled receptor on the plasmalemmal surface of the pancreatic acinar cell.

1995 • 63 citations

Seven-helix receptors: structure and modelling

1994 • 58 citations

Interaction of secretin5–27 and its analogues with hormone receptors on pancreatic acini

1979 • 56 citations

Characterization of Vasoactive Intestinal Peptide (VIP) receptors in mammalian lung

1986 • 54 citations

Human Vasoactive Intestinal Peptide1 Receptors Expressed by Stable Transfectants Couple to 2 Distinct Signaling Pathways

1994 • 53 citations

Antibodies against specific extracellular epitopes of the glucagon receptor block glucagon binding.

1996 • 53 citations

Vasoactive intestinal peptide (VIP) stimulates in vitro growth of VIP-1 receptor-bearing human pancreatic adenocarcinoma-derived cells.

1997 • 52 citations

Vasoactive intestinal peptide receptor regulation and reversible desensitization in human colonic carcinoma cells in culture.

1986 • 51 citations

Binding of vasoactive intestinal peptide and its stimulation of adenylate cyclase through two classes of receptors in rat liver membranes effects of 12 secretin analogues and 2 secretin fragments

1981 • 50 citations

Molecular Cloning and Functional Expression of a Human Pancreatic Secretin Receptor

1995 • 50 citations

Secretin at physiological doses inhibits gastric motility via a vagal afferent pathway

1995 • 48 citations

Subnanomolar concentration of VIP induces the nuclear translocation of protein kinase C in neonatal rat cortical astrocytes

1994 • 47 citations

Use of 125I-secretin to identify and characterize high-affinity secretin receptors on pancreatic acini

1983 • 44 citations

Importance of disulfide bonds in receptors for vasoactive intestinal peptide and secretin in rat pancreatic plasma membranes

1984 • 43 citations

Postreceptor modulation of action of VIP and secretin on pancreatic enzyme secretion by secretagogues that mobilize cellular calcium

1982 • 42 citations

Functionally different isoforms of the human calcitonin receptor result from alternative splicing of the gene transcript

1995 • 42 citations

Reduced peptide bond pseudopeptide analogues of secretin. A new class of secretin receptor antagonists.

1991 • 40 citations

Roles of Cholecystokinin Receptor Phosphorylation in Agonist-Stimulated Desensitization of Pancreatic Acinar Cells and Receptor-Bearing Chinese Hamster Ovary Cholecystokinin Receptor Cells

1997 • 40 citations

Properties and regulation of the coupling to adenylate cyclase of secretin receptors stably transfected in Chinese hamster ovary cells.

1994 • 39 citations

Inhibition of human neuroblastoma growth by a specific VIP antagonist

1994 • 39 citations

PHI—A new brain-gut peptide

1984 • 37 citations

Determination of the backbone conformation of secretin by restrained molecular dynamics on the basis of interproton distance data

1988 • 37 citations

Secretin Receptors in Human Pancreatic Membranes

1988 • 36 citations

Isoforms of the rat calcitonin receptor: consequences for ligand binding and signal transduction

1994 • 35 citations

Vasoactive intestinal polypeptide receptor binding sites in the human gastrointestinal tract: Localization by autoradiography

1989 • 35 citations

In-vivo stimulation of rat pancreatic acinar cells by infusion of secretin

1985 • 34 citations

The effect of oxyntomodulin (Glucagon-37) and glucagon on exocrine pancreatic secretion in the conscious rat

1987 • 33 citations

Molecular basis and species specificity of high affinity binding of vasoactive intestinal polypeptide by the rat secretin receptor.

1996 • 32 citations

Isolation and primary structure of rat secretin

1989 • 31 citations

Desensitization of glucagon‐like peptide 1 receptors in insulininsulinsecreting βTC3 cells: role of PKA‐independent mechanisms

1996 • 30 citations

Vasoactive intestinal peptide and forskolin regulate proliferation of the HT29 human colon adenocarcinoma cell line

1992 • 28 citations

Evidence for the formation of a functional complex between vasoactive intestinal peptide, its receptor, and Gs in lung membranes.

1992 • 27 citations

Addition of the (28–38) peptide sequence of PACAP to the VIP sequence modifies peptide selectivity and efficacy

1996 • 26 citations

Comparison of VIP-secretin receptors in rat and human lung

1981 • 26 citations

Phorbol ester induces loss of VIP stimulation of adenylate cyclase and VIP‐binding sites in HT29 cells

1987 • 24 citations

Conformation of peptides of the secretin-VIP-glucagon family in solution

1986 • 24 citations

Vasoactive intestinal peptide receptor/adenylate cyclase system: differences between agonist- and protein kinase C-mediated desensitization and further evidence for receptor internalization.

1988 • 23 citations

Small-cell lung carcinoma: Inhibition of proliferation by vasoactive intestinal peptide and helodermin and enhancement of inhibition by anti-bombesin antibody

1993 • 21 citations

Receptor antagonists for gastrointestinal peptides

1993 • 21 citations

Malignant transformation by G protein-coupled hormone receptors

1994 • 18 citations

Establishment and characterization of a new, spontaneously immortalized, pancreatic ductal cell line from the Syrian golden hamster

1995 • 18 citations

Chemical properties of the histidine residue of secretin: evidence for a specific intramolecular interaction

1989 • 18 citations

A G protein, not cyclic AMP, mediates effects of VIP on the inwardly rectifying K+ channels in endothelial cells.

1996 • 18 citations

Secretin receptors in the neuroglioma hybrid cell line NG108‐15

1990 • 17 citations

Pancreatic Cancer: The Role of Cholecystokinin?

1992 • 17 citations

Effect of secretin on growth of stomach, small intestine, and pancreas of developing rats

1990 • 17 citations

Functional and structural characterization of the secretin receptors in rat gastric glands: Desensitization and glycoprotein nature

1991 • 17 citations

Effects of VIP on the regulation of mucin secretion in cultured human pancreatic cancer cells (Capan-1)

1995 • 16 citations

Vasoactive intestinal peptide receptors on AR42J rat pancreatic acinar cells

1991 • 15 citations

The Effect of Secretin on Gastric H⁺and Pepsin Secretion and on Urinary Electrolyte Excretion in Man

1981 • 15 citations

Pancreatic secretory activity of secretin5–27 and substituted analogues

1978 • 14 citations

Secretin potentiates cholecystokinin‐stimulated amylase release by AR4‐2J cells via a stimulation of phospholipase C

1995 • 13 citations

Effect of N‐terminal iodination on the biological, immunological and receptor binding properties of secretin.

1984 • 12 citations

Immortalization of bovine pancreatic duct epithelial cells

1996 • 12 citations

Analogues and fragments of secretin

1984 • 12 citations

Cholesterol modulation of membrane fluidity and VIP receptor/effector system in rat prostatic epithelial cells

1991 • 11 citations

Cholecystokinin downregulates receptors for vasoactive intestinal peptide and secretin in rat pancreatic acini

1990 • 10 citations

Molecular architecture of secretin receptors: The specific covalent labelling of a 51 kDa peptide after cross‐linking of [¹²⁵I]iodo‐secretin to intact rat pancreatic acini

1989 • 10 citations

Differential effects of secretin‐fragments imply a dual mechanism of action for secretin

1991 • 9 citations

Role of protein kinase-A in homologous down-regulation of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid in human osteoblast-like SaOS-2 cells

1994 • 8 citations

Homologous and heterologous regulation of the helodermin/vasoactive‐intestinal‐peptide response in the murine radiation leukemia‐virus‐induced lymphoma cell line BL/VL₃

1989 • 8 citations

VIP receptors from porcine liver: High yield solubilization in a GTP-insensitive form

1991 • 6 citations

Homologous desensitization of calcitonin receptors and calcitonin-dependent adenylate cyclase in T47D cells

1993 • 6 citations

Stimulatory effects of Gila monster venom on rat pancreatic acini

1984 • 5 citations

Characterization of a human pancreatic secretin receptor and its expression in human ductal pancreatic adenocarcinomas

1995 • 2 citations