Myosin light chain phosphatase activities and the effects of phosphatase inhibitors in tonic and phasic smooth muscle.

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1988 • 1,699 citations

Cyanobacterial microcystin‐LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants

1990 • 1,627 citations

Physiology of the Gastrointestinal Tract

1988 • 732 citations

Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase.

1987 • 503 citations

An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues

1989 • 482 citations

The Protein Phosphatases Involved in Cellular Regulation. 1. Classification and Substrate Specificities

1983 • 471 citations

Electromechanical and Pharmacomechanical Coupling in Vascular Smooth Muscle

1984 • 432 citations

Receptor-coupled, Permeabilized Smooth Muscle

1989 • 429 citations

[37] Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle

1988 • 418 citations

Cytosolic heparin inhibits muscarinic and α-adrenergic Ca2+ release in smooth muscle

1989 • 344 citations

G-protein-mediated Ca2+ sensitization of smooth muscle contraction through myosin light chain phosphorylation

1991 • 326 citations

G protein-mediated inhibition of myosin light-chain phosphatase in vascular smooth muscle.

1991 • 319 citations

The protein phosphatases involved in cellular regulation

1985 • 261 citations

Protein kinase C modulates in vitro phosphorylation of the smooth muscle heavy meromyosin by myosin light chain kinase.

1984 • 249 citations

Phosphorylation of the 20,000-dalton light chain of smooth muscle myosin by the calcium-activated, phospholipid-dependent protein kinase. Phosphorylation sites and effects of phosphorylation.

1987 • 224 citations

[33] Classification of protein- serine/threonine phosphatases: identification and quantitation in cell extracts

1991 • 223 citations

Myoplasmic [Ca2+] determines myosin phosphorylation in agonist-stimulated swine arterial smooth muscle.

1988 • 222 citations

Tautomycin from the bacterium Streptomyces verticillatus

1990 • 191 citations

Irreversible thiophosphorylation and activation of tension in functionally skinned rabbit ileum strips by [35S]ATP gamma S.

1979 • 181 citations

Effects of Ca2+ on the conformation and enzymatic activity of smooth muscle myosin.

1985 • 170 citations

Proteolysis of smooth muscle myosin light chain kinase. Formation of inactive and calmodulin-independent fragments.

1987 • 156 citations

Proteolysis of smooth muscle myosin by Staphylococcus aureus protease: preparation of heavy meromyosin and subfragment 1 with intact 20,000-dalton light chains

1985 • 156 citations

Cytoplasmic free calcium, myosin light chain phosphorylation, and force in phasic and tonic smooth muscle.

1988 • 147 citations

Cross-bridge kinetics, cooperativity, and negatively strained cross-bridges in vertebrate smooth muscle. A laser-flash photolysis study.

1988 • 140 citations

Purification and characterization of a multisubunit phosphatase from turkey gizzard smooth muscle. The effect of calmodulin binding to myosin light chain kinase on dephosphorylation.

1983 • 120 citations

Characterization of a mammalian smooth muscle myosin heavy-chain gene: complete nucleotide and protein coding sequence and analysis of the 5' end of the gene.

1991 • 120 citations

A new antibiotic, tautomycin.

1987 • 112 citations

[40] Protein phosphatase inhibitor-1 and inhibitor-2 from rabbit skeletal muscle

1988 • 109 citations

Calcium-independent myosin light chain kinase of smooth muscle. Preparation by limited chymotryptic digestion of the calcium ion dependent enzyme, purification and characterization

1982 • 101 citations

Distribution of isoelectric variants of the 17,000-dalton myosin light chain in mammalian smooth muscle.

1988 • 94 citations

Mechanism of contracture on cooling of caffeine‐treated frog skeletal muscle fibres.

1988 • 89 citations

Two smooth muscle myosin heavy chains differ in their light meromyosin fragment

1988 • 85 citations

Effects of okadaic acid on isometric tension and myosin phosphorylation of chemically skinned guinea‐pig taenia coli.

1988 • 83 citations

Contractile effects of okadaic acid, a novel ionophore-like substance from black sponge, on isolated smooth muscles under the condition of Ca deficiency.

1982 • 83 citations

Myosin dephosphorylation during rapid relaxation of hog carotid artery smooth muscle

1989 • 82 citations

The Protein Phosphatases Invloved in Cellular Regulation. 4. Classification of Two Homogeneous Myosin Light Chain Phosphatases from Smoth Muscle as Protein Phosphatase-2A1 and 2C, and a Homogeneous Protein Phosphatase from Reticulocytes Active on Protein Synthesis Initiation Factor eIF-2 as Protein Phosphatase-2A2

1983 • 81 citations

Excitation-contraction coupling and electrical events in two types of vascular smooth muscle

1969 • 80 citations

Purification and characterization of a smooth muscle myosin phosphatase from turkey gizzards.

1985 • 79 citations

Characterization of a Mg2+-dependent phosphatase from turkey gizzard smooth muscle.

1983 • 77 citations

Distinct vascular and intestinal smooth muscle myosin heavy chain mRNAs are encoded by a single-copy gene in the chicken

1990 • 76 citations

Kinetics of contraction initiated by flash photolysis of caged adenosine triphosphate in tonic and phasic smooth muscles.

1989 • 73 citations

Ca2+ channel blockers distinguish between G protein-coupled pharmacomechanical Ca2+ release and Ca2+ sensitization

1991 • 73 citations

The dependence of unloaded shortening velocity on Ca++, calmodulin, and duration of contraction in "chemically skinned" smooth muscle.

1983 • 71 citations

Dephosphorylation of myosin by the catalytic subunit of a type-2 phosphatase produces relaxation of chemically skinned uterine smooth muscle.

1985 • 71 citations

A novel protein phosphatase inhibitor, tautomycin Effect on smooth muscle

1991 • 71 citations

The myosin-bound form of protein phosphatase 1 (PP-1M) is the enzyme that dephosphorylates native myosin in skeletal and cardiac muscles

1988 • 68 citations

Purification of a myosin phosphatase from bovine aortic smooth muscle.

1982 • 62 citations

Purified rabbit brain protein kinase C relaxes skinned vascular smooth muscle and phosphorylates myosin light chain

1987 • 58 citations

Identification of a third form of protein phosphatase 1 in rabbit skeletal muscle that is associated with myosin

1988 • 58 citations

Phosphorylation of smooth muscle myosin by type II Ca2+/calmodulin-dependent protein kinase

1990 • 49 citations

Effects of okadaic acid on cytosolic calcium concentrations and on contractions of the porcine coronary artery

1989 • 47 citations

Direct activation by okadaic acid of the contractile elements in the smooth muscle of guinea-pig taenia coli

1987 • 40 citations

Protein phosphatase composition in the smooth muscle of guinea-pig ileum studied with okadaic acid and inhibitor 2

1989 • 33 citations

Soluble relaxation factor from vascular smooth muscle: A myosin light chain phosphatase?

1982 • 28 citations

Turkey gizzard smooth muscle myosin phosphatase-III is a novel protein phosphatase.

1991 • 27 citations

The ATPMg-dependent phosphatase is present in mammalian vascular smooth muscle

1982 • 15 citations

The modulator protein dissociates the catalytic subunit of hepatic protein phosphatase G from glycogen

1988 • 15 citations