Apoptotic cell death occurs in hippocampal neurons cultured in a high oxygen atmosphere

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

1988 • 2,572 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

The aging process.

1981 • 1,871 citations

Nitric oxide, a novel neuronal messenger

1992 • 1,864 citations

Developmental cell death: morphological diversity and multiple mechanisms

1990 • 1,695 citations

Trophic factors and neuronal survival

1989 • 1,631 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Carbon Monoxide: a Putative Neural Messenger

1993 • 1,519 citations

Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?

1992 • 1,268 citations

Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions

1949 • 974 citations

NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices

1989 • 912 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

Death and the cell

1986 • 616 citations

Do all programmed cell deaths occur via apoptosis?

1993 • 545 citations

Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic-factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells.

1989 • 405 citations

The neurotrophic theory and naturally occurring motoneuron death

1989 • 397 citations

Suppression of programmed neuronal death by sustained elevation of cytoplasmic calcium

1992 • 363 citations

Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: Evidence for the role of cell death genes

1990 • 332 citations

Cell death of motoneurons in the chick embryo spinal cord. I. A light and electron microscopic study of naturally occurring and induced cell loss during development

1978 • 318 citations

Naturally Occurring Neuron Death and Its Regulation by Developing Neural Pathways

1982 • 306 citations

Chromosomal Translocations in Lymphoid Malignancies Reveal Novel Proto-Oncogenes

1992 • 267 citations

The Protooncogene bcl‐2 Inhibits Apoptosis in PC12 Cells

1993 • 222 citations

Developmental change in the nerve growth factor action from induction of choline acetyltransferase to promotion of cell survival in cultured basal forebrain cholinergic neurons from postnatal rats

1988 • 208 citations

Cell death of motoneurons in the chick embryo spinal cord

1984 • 203 citations

Differential effects of nerve-growth factor and glioma-conditioned medium on neurons cultured from various regions of fetal rat central nervous system

1986 • 94 citations

Differential effects of nerve-growth factor and glioma-conditioned medium on neurons cultured from various regions of fetal rat central nervous system

1986 • 85 citations

Both nerve growth factor and high K+ concentrations support the survival of chick embryo sympathetic neurons Evidence for a common mechanism of action

1983 • 61 citations

Basic fibroblast growth factor rescues CNS neurons from cell death caused by high oxygen atmosphere in culture

1992 • 57 citations

High oxygen atmosphere for neuronal cell culture with nerve growth factor. II. Survival and growth of clonal rat pheochromocytoma PC12h cells

1990 • 31 citations

High oxygen atmosphere for neuronal cell culture with nerve growth factor. I. Primary culture of basal forebrain cholinergic neurons from fetal and postnatal rats

1990 • 17 citations