Leptin reduces food intake but does not alter weight regain following food deprivation in the rat

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

1996 • 6,254 citations

Leptin and the regulation of body weight in mammals

1998 • 5,366 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1995 • 3,730 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

1999 • 1,959 citations

Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

1995 • 1,630 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

Recombinant Leptin for Weight Loss in Obese and Lean Adults

1999 • 1,408 citations

The role of depot fat in the hypothalamic control of food intake in the rat

1953 • 1,400 citations

Leptin enters the brain by a saturable system independent of insulin

1996 • 1,210 citations

Hypothalamic control of food intake in rats and cats.

1951 • 1,187 citations

Transient increase in obese gene expression after food intake or insulin administration

1995 • 1,102 citations

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

1997 • 1,043 citations

OBESE, A NEW MUTATION IN THE HOUSE MOUSE*

1950 • 1,020 citations

Hypothalamic lesions and adiposity in the rat

1940 • 965 citations

Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects.

1996 • 784 citations

Effects of parabiosis of obese with diabetes and normal mice

1973 • 728 citations

Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food.

1991 • 678 citations

What’s in a Name? In Search of Leptin’s Physiologic Role¹

1998 • 527 citations

Responses of Leptin to Short-Term Fasting and Refeeding in Humans: A Link With Ketogenesis but Not Ketones Themselves

1996 • 516 citations

Model for the regulation of energy balance and adiposity by the central nervous system

1999 • 339 citations

A Leptin Dose-Response Study in Obese (ob/ob) and Lean (+/?) Mice

1998 • 296 citations

Defense of differfing body weight set points in diet-induced obese and resistant rats

1998 • 252 citations

Distinct Physiologic and Neuronal Responses to Decreased Leptin and Mild Hyperleptinemia¹

1999 • 250 citations

Set points for body weight and fat

1977 • 245 citations

Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status

1990 • 243 citations

Evidence for Leptin Binding to Proteins in Serum of Rodents and Humans: Modulation With Obesity

1996 • 236 citations

Body Weight Set-Points: Determination and Adjustment

1997 • 198 citations

Effects of weekly administration of pegylated recombinant human OB protein on appetite profile and energy metabolism in obese men

2001 • 123 citations

The effect of leptin on Lep expression is tissue-specific and nutritionally regulated

1999 • 79 citations

Enhanced inhibitory feeding response to alpha-melanocyte stimulating hormone in the diet-induced obese rat

2001 • 77 citations

Dose-Dependent Effects of Central Leptin Gene Therapy on Genes That Regulate Body Weight and Appetite in the Hypothalamus

2001 • 74 citations

Pharmacotherapy of obesity: targets and perspectives

2001 • 72 citations

Therapeutic Fasting in Morbid Obesity

1977 • 71 citations

Defense of a lowered weight maintenance level by lateral hypothamically lesioned rats: Evidence from a restriction-refeeding regimen

1977 • 53 citations

Effects of vagal and splanchnic section on food intake, weight, serum leptin and hypothalamic neuropeptide Y in rat

2001 • 52 citations

Therapeutic fasting in morbid obesity.

1977 • 51 citations

Effect of food deprivation and leptin repletion on the plasma levels of estrogen (E2) and NADPH-d reactivity in the ventromedial and arcuate nuclei of the hypothalamus in the female rats

2000 • 31 citations

Modulation of neuropeptide Y overflow by leptin in the rat hypothalamus, cerebral cortex and medulla

1998 • 29 citations

Leptin responsiveness of juvenile rats: proof of leptin function within the physiological range

2001 • 13 citations