Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity

Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions.

1997 • 974 citations

Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis.

1995 • 596 citations

Origin of Murine B Cell Lineages

1993 • 579 citations

Positive Selection of Natural Autoreactive B Cells

1999 • 574 citations

Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice. Demonstration of epitopes of oxidized low density lipoprotein in human plasma.

1996 • 557 citations

Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid–protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins

1999 • 552 citations

Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL.

1994 • 541 citations

IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts

1981 • 509 citations

ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum.

1994 • 498 citations

The Three-Dimensional Structure of a Phosphorylcholine-Binding Mouse Immunoglobulin Fab and the Nature of the Antigen Binding Site

1974 • 465 citations

Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: Evidence that oxidation-specific epitopes mediate macrophage recognition

1999 • 461 citations

Antiphospholipid antibodies are directed against epitopes of oxidized phospholipids. Recognition of cardiolipin by monoclonal antibodies to epitopes of oxidized low density lipoprotein.

1996 • 354 citations

Immunization of LDL Receptor–Deficient Mice With Homologous Malondialdehyde-Modified and Native LDL Reduces Progression of Atherosclerosis by Mechanisms Other Than Induction of High Titers of Antibodies to Oxidative Neoepitopes

1998 • 324 citations

Anti-phosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniae.

1982 • 303 citations

Increased Autoantibody Titers Against Epitopes of Oxidized LDL in LDL Receptor–Deficient Mice With Increased Atherosclerosis

1995 • 247 citations

B Cell Antigen Receptor Specificity and Surface Density Together Determine B-1 versus B-2 Cell Development

1999 • 218 citations

An unbiased analysis of V(H)-D-J(H) sequences from B-1a, B-1b, and conventional B cells.

1997 • 207 citations

All T15 Id-positive antibodies (but not the majority of V_HT15⁺ antibodies) are produced by peritoneal CD5⁺ B lymphocytes

1990 • 197 citations

Phosphorylcholine: friend or foe of the immune system?

1999 • 166 citations

The epitopes for some antiphospholipid antibodies are adducts of oxidized phospholipid and β₂glycoprotein 1 (and other proteins)

1997 • 142 citations

Oxidized Phosphatidylcholines That Modify Proteins

1996 • 128 citations

Monoclonal vs. heterogeneous anti‐H‐8 antibodies in the analysis of the anti‐phosphorylcholine response in BALB/c mice

1981 • 127 citations

The Chosen Few? Positive Selection and the Generation of Naive B Lymphocytes

1999 • 107 citations

Clonal nature of the immune response to phosphorylcholine. II. Idiotypic specificity and binding characteristics of anti-phosphorylcholine antibodies.

1974 • 80 citations

The Frequency of Phosphorylcholine-Specific B Cells in Conventional and Germfree Balb/c Mice

1975 • 79 citations

B-1 Cell Development: Evidence for an Uncommitted Immunoglobulin (Ig)M+ B Cell Precursor in B-1 Cell Differentiation

1998 • 78 citations

Rat anti-T15 monoclonal antibodies with specificity for VH and VH-VL epitopes

1984 • 57 citations

T Cell‐Dependent Antibody Production by Ly‐1 B Cells^a

1992 • 46 citations

Heavy-chain class switch does not terminate somatic mutation.

1990 • 43 citations

Clonal nature of the immune response to phosphocholine. VII. Evidence throughout inbred mice for molecular similarities among antibodies bearing the T15 idiotype.

1980 • 36 citations

The Dual Phases of the Response to Neonatal Exposure to a VH Family-Restricted Staphylococcal B Cell Superantigen

1998 • 32 citations

Antigen binding and idiotype analysis of antibodies obtained after electroporation of heavy and light chain genes encoding phosphocholine-specific antibodies: a model for T15-idiotype dominance.

1992 • 29 citations