Mechanistic link between lidocaine block and inactivation probed by outer pore mutations in the rat μ1 skeletal muscle sodium channel

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

1977 • 1,746 citations

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

1995 • 1,686 citations

Molecular mechanism for an inherited cardiac arrhythmia

1995 • 964 citations

Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels

1977 • 899 citations

Molecular Determinants of State-Dependent Block of Na ⁺ Channels by Local Anesthetics

1994 • 829 citations

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation.

1992 • 810 citations

Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel

1992 • 708 citations

The Inhibition of Sodium Currents in Myelinated Nerve by Quaternary Derivatives of Lidocaine

1973 • 660 citations

Lidocaine block of cardiac sodium channels.

1983 • 660 citations

Primary structure and functional expression of a mammalian skeletal muscle sodium channel

1989 • 561 citations

Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels.

1996 • 488 citations

Dynamic Rearrangement of the Outer Mouth of a K+ Channel during Gating

1996 • 451 citations

Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA.

1975 • 387 citations

Molecular kinetics of voltage-dependent Na+ channels

1991 • 243 citations

The site of action and active form of local anesthetics. II. Experiments with quaternary compounds.

1970 • 221 citations

Use-Dependent Blockers and Exit Rate of the Last Ion from the Multi-Ion Pore of a K ⁺ Channel

1996 • 218 citations

Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons

1978 • 204 citations

Inhibition of sodium currents in frog ranvier node treated with local anesthetics Role of slow sodium inactivation

1976 • 200 citations

Impaired slow inactivation in mutant sodium channels

1996 • 179 citations

Fast and slow gating of sodium channels encoded by a single mRNA

1990 • 162 citations

The Effects of External Potassium and Long Duration Voltage Conditioning on the Amplitude of Sodium Currents in the Giant Axon of the Squid, Loligo pealei

1969 • 158 citations

Multiple gating modes and the effect of modulating factors on the μI sodium channel

1991 • 158 citations

Slow inactivation differs among mutant Na channels associated with myotonia and periodic paralysis

1997 • 136 citations

External pore residue mediates slow inactivation in mu 1 rat skeletal muscle sodium channels.

1996 • 132 citations

Inactivation defects caused by myotonia-associated mutations in the sodium channel III-IV linker.

1996 • 132 citations

A mutation in segment IVS6 disrupts fast inactivation of sodium channels.

1994 • 122 citations

Molecular determinants of drug access to the receptor site for antiarrhythmic drugs in the cardiac Na+ channel.

1995 • 117 citations

On the Molecular Nature of the Lidocaine Receptor of Cardiac Na ⁺ Channels

1995 • 116 citations

Slow changes in membrane permeability and long‐lasting action potentials in axons perfused with fluoride solutions

1970 • 115 citations

A mutation in segment I-S6 alters slow inactivation of sodium channels

1997 • 114 citations

Structure of the sodium channel pore revealed by serial cysteine mutagenesis.

1996 • 111 citations

Evidence for the involvement of more than one mRNA species in controlling the inactivation process of rat and rabbit brain Na channels expressed in Xenopus oocytes

1988 • 97 citations

Local anesthetics as effectors of allosteric gating. Lidocaine effects on inactivation-deficient rat skeletal muscle Na channels.

1996 • 96 citations

A molecular basis for gating mode transitions in human skeletal muscle Na⁺ channels

1993 • 83 citations

Modification of the Na+ current conducted by the rat skeletal muscle ? subunit by coexpression with a human brain ? subunit

1993 • 83 citations

A mutation in the pore of the sodium channel alters gating

1995 • 77 citations

Is there a second external lidocaine binding site on mammalian cardiac cells?

1989 • 74 citations

Functional consequences of lidocaine binding to slow-inactivated sodium channels.

1996 • 71 citations

Coexpression of beta 1 with cardiac sodium channel alpha subunits in oocytes decreases lidocaine block.

1996 • 63 citations

Two human paramyotonia congenita mutations have opposite effects on lidocaine block of Na+ channels expressed in a mammalian cell line.

1996 • 60 citations

Coupling between fast and slow inactivation revealed by analysis of a point mutation (F1304Q) in mu 1 rat skeletal muscle sodium channels.

1996 • 36 citations

Modal behavior of the mu 1 Na+ channel and effects of coexpression of the beta 1-subunit

1996 • 30 citations

Ca-sensitive slow inactivation and lidocaine-induced block of sodium channels in rat cardiac cells

1991 • 18 citations