Inhibition of DLX-7 homeobox gene causes decreased expression of GATA-1 and c- myc genes and apoptosis

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Homeobox genes and axial patterning

1992 • 2,688 citations

Antisense Oligonucleotides as Therapeutic Agents—Is the Bullet Really Magical?

1993 • 1,306 citations

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

1986 • 1,118 citations

The structure and function of the homeodomain

1989 • 1,007 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

Human fetal gγ- and Aγ-globin genes: Complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes

1980 • 947 citations

Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells

1989 • 931 citations

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1994 • 747 citations

Gene inhibition using antisense oligodeoxynucleotides

1994 • 746 citations

A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B all

1990 • 726 citations

Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor

1990 • 692 citations

HEL Cells: A New Human Erythroleukemia Cell Line with Spontaneous and Induced Globin Expression

1982 • 655 citations

Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo.

1995 • 606 citations

Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt- 3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries

1993 • 570 citations

Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

1986 • 489 citations

A c- myb Antisense Oligodeoxynucleotide Inhibits Normal Human Hematopoiesis in Vitro

1988 • 439 citations

Deregulation of a Homeobox Gene, HOX11, by the t(10;14) in T Cell Leukemia

1991 • 411 citations

Distal-less encodes a homoeodomain protein required for limb development in Drosophila

1989 • 389 citations

Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA.

1988 • 374 citations

The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif.

1989 • 363 citations

Nucleotide sequence of cloned cDNA of human c-myc oncogene

1983 • 316 citations

RNA binding and translational suppression by bicoid

1996 • 313 citations

Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis.

1995 • 306 citations

Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells.

1992 • 295 citations

Hypoxanthine-guanine phosphoribosyltransferase genes of mouse and Chinese hamster: construction and sequence analysis of cDNA recombinants

1982 • 295 citations

Cloning and characterization of two members of the vertebrate Dlx gene family.

1994 • 276 citations

A mouse gene related to Distal-less shows a restricted expression in the developing forebrain

1991 • 273 citations

Isolation and characterization of a novel cDNA clone encoding a homeodomain that is developmentally regulated in the ventral forebrain

1991 • 209 citations

The mouse Dlx-2 (Tes-1) gene is expressed in spatially restricted domains of the forebrain, face and limbs in midgestation mouse embryos

1993 • 209 citations

Involvement of BCL-2 in glucocorticoid-induced apoptosis of human pre-B-leukemias.

1992 • 188 citations

Megakaryoblastic differentiation of proerythroblastic K562 cell-line cells

1984 • 178 citations

Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus.

1986 • 174 citations

The Hox11 gene is essential for cell survival during spleen development

1995 • 162 citations

Expression of the murine Dlx-1 homeobox gene during facial, ocular and limb development

1992 • 158 citations

The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein.

1991 • 149 citations

Spatially restricted expression of a member of a new family of murine Distal-less homeobox genes in the developing forebrain.

1991 • 128 citations

Human erythroleukemia cell line (HEL) undergoes a drastic macrophage- like shift with TPA

1983 • 126 citations

Estrogen-Induced Apoptosis by Inhibition of the Erythroid Transcription Factor GATA-1

1996 • 112 citations

Nuclear Delivery of Antisense Oligodeoxynucleotides Through Reversible Permeabilization of Human Leukemia Cells with Streptolysin O

1995 • 90 citations

Modulation of homeobox gene expression alters the phenotype of human hematopoietic cell lines.

1992 • 81 citations

Genomic Analysis of a New Mammalian Distal-less Gene: Dlx7

1996 • 77 citations

Apoptosis in erythroid progenitors deprived of erythropoietin occurs during the G1 and S phases of the cell cycle without growth arrest or stabilization of wild-type p53.

1994 • 73 citations

The expression pattern of erythrocyte/megakaryocyte-related transcription factors GATA-1 and the stem cell leukemia gene correlates with hematopoietic differentiation and is associated with outcome of acute myeloid leukemia

1995 • 71 citations

A potential role for antisense oligonucleotide analogues in the development of oncogene targeted cancer chemotherapy.

1990 • 69 citations

The role of the homeobox gene, HOX B7, in human myelomonocytic differentiation

1995 • 63 citations

Members of the Dlx‐and NKx2‐gene families are regionally expressed in the developing forebrain

1993 • 63 citations

Hemin control of heme biosynthesis and catabolism in a human leukemia cell line

1980 • 60 citations

Retinoic acid inhibits interleukin-6-induced macrophage differentiation and apoptosis in a murine hematopoietic cell line, Y6

1992 • 55 citations

Role for E2F1 in p210 BCR-ABL downstream regulation of c-myc transcription initiation. Studies in murine myeloid cells.

1995 • 51 citations

A homeobox gene of the Antennapedia class is required for human adult erythropoiesis.

1993 • 47 citations

Interleukin-9 stimulates the proliferation of human myeloid leukemic cells

1996 • 35 citations

Dlx2 (Tes1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2

1992 • 32 citations

The human brain homeogene, DLX-2: cDNA sequence and alignment with the murine homologue

1993 • 22 citations

Apoptosis in Erythroid Progenitors Deprived of Erythropoietin Occurs during the G₁ and S Phases of the Cell Cycle without Growth Arrest or Stabilization of Wild-Type p53

1994 • 11 citations