High Commitment of Embryonic Keratinocytes to Terminal Differentiation through a Notch1-caspase 3 Regulatory Mechanism

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis

1999 • 2,796 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Calcium regulation of growth and differentiation of mouse epidermal cells in culture

1980 • 1,810 citations

Signalling downstream of activated mammalian Notch

1995 • 1,375 citations

GSK-3α regulates production of Alzheimer's disease amyloid-β peptides

2003 • 1,145 citations

Many cuts to ruin: a comprehensive update of caspase substrates

2003 • 1,021 citations

The secret life of the hair follicle

1992 • 919 citations

Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain

2001 • 876 citations

Notch1 is required for the coordinate segmentation of somites

1995 • 860 citations

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

2001 • 849 citations

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

1998 • 843 citations

Notch1 is essential for postimplantation development in mice.

1994 • 731 citations

Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells.

1995 • 684 citations

Caspase 3 activity is required for skeletal muscle differentiation

2002 • 541 citations

Programming gene expression in developing epidermis

1994 • 487 citations

Proteolytic Activation of Protein Kinase C δ by an ICE/CED 3-like Protease Induces Characteristics of Apoptosis

1996 • 484 citations

CPP32/Apopain Is a Key Interleukin 1β Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis

1996 • 480 citations

Stimulation of human epidermal differentiation by Delta–Notch signalling at the boundaries of stem-cell clusters

2000 • 440 citations

Cell shape controls terminal differentiation of human epidermal keratinocytes.

1988 • 396 citations

Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1

1999 • 388 citations

Patterned acquisition of skin barrier function during development

1998 • 384 citations

Caspase Activation Is Required for Terminal Erythroid Differentiation

2001 • 383 citations

Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-κB and PPARγ

2002 • 315 citations

Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages during Skin Development

1998 • 311 citations

Specific involvement of caspases in the differentiation of monocytes into macrophages

2002 • 306 citations

A Role for Caspases in Lens Fiber Differentiation

1998 • 294 citations

Stem-cell hierarchy in skin cancer

2003 • 271 citations

Apoptosis in human skin development: Morphogenesis, periderm, and stem cells

1994 • 259 citations

Coordinate changes in gene expression which mark the spinous to granular cell transition in epidermis are regulated by protein kinase C.

1993 • 256 citations

Homeobox genes in normal and malignant cells

2001 • 246 citations

Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosisin vivo

1998 • 244 citations

Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing

2000 • 236 citations

Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins

2002 • 232 citations

A common enzyme connects Notch signaling and Alzheimer's disease

2000 • 214 citations

Induction of Differentiation in Normal Human Keratinocytes by Adenovirus-Mediated Introduction of the η and δ Isoforms of Protein Kinase C

1998 • 197 citations

Caspase activation in the terminal differentiation of human epidermal keratinocytes

1999 • 196 citations

Isolation and Functional Analysis of a cDNA for Human Jagged2, a Gene Encoding a Ligand for the Notch1 Receptor

1997 • 192 citations

Synthetic peptides corresponding to keratin subunits elicit highly specific antibodies.

1984 • 186 citations

The TGF-β2 Isoform Is Both a Required and Sufficient Inducer of Murine Hair Follicle Morphogenesis

1999 • 162 citations

A new look into an old problem: keratins as tools to investigate determination, morphogenesis, and differentiation in skin.

1989 • 155 citations

Notch/RBP-J Signaling Regulates Epidermis/Hair Fate Determination of Hair Follicular Stem Cells

2003 • 145 citations

γ‐Secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations inDrosophila

2002 • 142 citations

Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers

2000 • 111 citations

Identification and Functional Analysis of the Rat Caspase-3 Gene Promoter

2002 • 77 citations

Keratinocytes Become Terminally Differentiated in a Process Involving Programmed Cell Death

1997 • 76 citations

Chemical Genetics

2003 • 61 citations

Activation of Protein Kinase C Triggers Irreversible Cell CycleWithdrawal In Human Keratinocytes

2002 • 42 citations

Skin development: Delta laid bare

2000 • 28 citations