Network Discovery Pipeline Elucidates Conserved Time-of-Day–Specific cis-Regulatory Modules

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

1995 • 93,704 citations

Statistical significance for genomewide studies

2003 • 9,411 citations

Science

2023 • 5,648 citations

A Genomic Perspective on Protein Families

1997 • 3,531 citations

Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

2002 • 2,248 citations

Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data

2003 • 1,713 citations

Orchestrated Transcription of Key Pathways in Arabidopsis by the Circadian Clock

2000 • 1,592 citations

Plant Circadian Clocks Increase Photosynthesis, Growth, Survival, and Competitive Advantage

2005 • 1,411 citations

A transcription factor response element for gene expression during circadian night

2002 • 852 citations

Circadian Regulator CLOCK Is a Histone Acetyltransferase

2006 • 848 citations

Plant Circadian Rhythms

2006 • 791 citations

System-level identification of transcriptional circuits underlying mammalian circadian clocks

2005 • 765 citations

Sugars and Circadian Regulation Make Major Contributions to the Global Regulation of Diurnal Gene Expression in Arabidopsis

2005 • 677 citations

Molecular basis of seasonal time measurement in Arabidopsis

2002 • 676 citations

Rhythmic histone acetylation underlies transcription in the mammalian circadian clock

2002 • 665 citations

Rhythmic growth explained by coincidence between internal and external cues

2007 • 653 citations

Predicting Gene Expression from Sequence

2004 • 600 citations

Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions

2006 • 572 citations

Enhanced Fitness Conferred by Naturally Occurring Variation in the Circadian Clock

2003 • 454 citations

Experimental validation of a predicted feedback loop in the multi‐oscillator clock of Arabidopsis thaliana

2006 • 428 citations

Diurnal Changes in the Transcriptome Encoding Enzymes of Starch Metabolism Provide Evidence for Both Transcriptional and Posttranscriptional Regulation of Starch Metabolism in Arabidopsis Leaves

2004 • 419 citations

The short-period mutant, toc1-1, alters circadian clock regulation of multiple outputs throughout development in Arabidopsis thaliana

1998 • 388 citations

The Diurnal Project: Diurnal and Circadian Expression Profiling, Model-based Pattern Matching, and Promoter Analysis

2007 • 383 citations

The Adaptive Value of Circadian Clocks

2004 • 358 citations

The Circadian Clock Regulates Auxin Signaling and Responses in Arabidopsis

2007 • 349 citations

Interplay of Circadian Clocks and Metabolic Rhythms

2006 • 335 citations

PSEUDO-RESPONSE REGULATOR 7 and 9 Are Partially Redundant Genes Essential for the Temperature Responsiveness of the Arabidopsis Circadian Clock

2005 • 321 citations

FLOWERING LOCUS CMediates Natural Variation in the High-Temperature Response of theArabidopsisCircadian Clock

2006 • 306 citations

Circadian dysfunction causes aberrant hypocotyl elongation patterns in Arabidopsis

1999 • 290 citations

Coupling of Human Circadian and Cell Cycles by the Timeless Protein

2005 • 283 citations

Integration of circadian and phototransduction pathways in the network controlling CAB gene transcription in Arabidopsis

1996 • 272 citations

Establishing glucose- and ABA-regulated transcription networks in Arabidopsis by microarray analysis and promoter classification using a Relevance Vector Machine

2006 • 248 citations

Identification of Promoter Motifs Involved in the Network of Phytochrome A-Regulated Gene Expression by Combined Analysis of Genomic Sequence and Microarray Data

2003 • 247 citations

A novel computational model of the circadian clock in Arabidopsis that incorporates PRR7 and PRR9

2006 • 240 citations

A KaiC-associating SasA–RpaA two-component regulatory system as a major circadian timing mediator in cyanobacteria

2006 • 218 citations

Temperature Synchronization of the Drosophila Circadian Clock

2005 • 217 citations

Biogeography of Arabidopsis thaliana (L.) Heynh. (Brassicaceae)

2002 • 212 citations

Assembling a Clock for All Seasons: Are There M and E Oscillators in the Genes?

2001 • 208 citations

Positive and Negative Factors Confer Phase-Specific Circadian Regulation of Transcription in Arabidopsis

2005 • 201 citations

A Functional Link between Rhythmic Changes in Chromatin Structure and theArabidopsisBiological Clock

2007 • 195 citations

Enhancer Trapping Reveals Widespread Circadian Clock Transcriptional Control in Arabidopsis

2003 • 176 citations

Internal telomeric repeats and ‘TCP domain’ protein‐binding sites co‐operate to regulate gene expression in Arabidopsis thaliana cycling cells

2003 • 175 citations

Temperature Regulates Transcription in the Zebrafish Circadian Clock

2005 • 169 citations

Phase-Specific Circadian Clock Regulatory Elements in Arabidopsis

2002 • 156 citations

Circadian rhythms in gene transcription imparted by chromosome compaction in the cyanobacterium Synechococcus elongatus

2006 • 152 citations

Integration of Light and Temperature in the Regulation of Circadian Gene Expression in Drosophila

2007 • 151 citations

Two Arabidopsis circadian oscillators can be distinguished by differential temperature sensitivity

2003 • 150 citations

The Neurospora Checkpoint Kinase 2: A Regulatory Link Between the Circadian and Cell Cycles

2006 • 138 citations

Spatio‐temporal leaf growth patterns of Arabidopsis thaliana and evidence for sugar control of the diel leaf growth cycle

2007 • 133 citations

Molecular mechanism of temperature sensing by the circadian clock of Neurospora crassa

2005 • 123 citations

Execution of the Circadian Negative Feedback Loop in Neurospora Requires the ATP-Dependent Chromatin-Remodeling Enzyme CLOCKSWITCH

2007 • 119 citations

Seasonal Changes in the Germination Responses of Buried Seeds of Arabidopsis thaliana and Ecological Interpretation

1983 • 117 citations

Temperature-modulated Alternative Splicing and Promoter Use in the Circadian Clock Genefrequency

2005 • 116 citations

Day and Night Temperature Responses in Arabidopsis: Effects on Gibberellin and Auxin Content, Cell Size, Morphology and Flowering Time

2003 • 99 citations

Plant interstitial telomere motifs participate in the control of gene expression in root meristems

1999 • 94 citations

Involvement of indole-3-acetic acid in the circadian growth of the first internode of Arabidopsis

1999 • 84 citations

Interstitial Telomeric Repeats within the Arabidopsis thaliana Genome

1994 • 74 citations

Molecular and Statistical Tools for Circadian Transcript Profiling

2005 • 59 citations

AtSig5 Is an Essential Nucleus-Encoded Arabidopsis σ-Like Factor

2003 • 55 citations

No Promoter Left Behind: Global Circadian Gene Expression in Cyanobacteria

2006 • 54 citations

Digital Signal Processing Reveals Circadian Baseline Oscillation in Majority of Mammalian Genes

2007 • 54 citations

In synergy with various cis‐acting elements, plant insterstitial telomere motifs regulate gene expression in Arabidopsis root meristems

2000 • 53 citations

Identification ofcis-Acting Elements Important for Expression of the Starch-Branching Enzyme I Gene in Maize Endosperm

1999 • 50 citations

Promotive Effects of the Peptidyl Plant Growth Factor, Phytosulfokine-α, on the Growth and Chlorophyll Content ofArabidopsisSeedlings under High Night-time Temperature Conditions

1999 • 41 citations