Cartilage tumours and bone development: molecular pathology and possible therapeutic targets

World Health Organization Classification of Tumours

2002 • 5,829 citations

World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone

2002 • 2,836 citations

Developmental regulation of the growth plate

2003 • 2,694 citations

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

2009 • 2,296 citations

Pathology and genetics of tumours of soft tissue and bone

2002 • 1,877 citations

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

1999 • 1,682 citations

HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo

1995 • 1,380 citations

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

2009 • 1,089 citations

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

2009 • 987 citations

The Clinical Approach Towards Chondrosarcoma

2008 • 660 citations

Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development.

1989 • 440 citations

BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation

2001 • 432 citations

Chondrosarcoma of Bone

1999 • 418 citations

The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate

1998 • 377 citations

Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study

2009 • 334 citations

The malignant potential of enchondromatosis.

1987 • 328 citations

Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer

2008 • 321 citations

Multiple osteochondromas

2008 • 298 citations

Risk factors for survival and local control in chondrosarcoma of bone

2002 • 291 citations

Ext1-Dependent Heparan Sulfate Regulates the Range of Ihh Signaling during Endochondral Ossification

2004 • 273 citations

A mutant PTH/PTHrP type I receptor in enchondromatosis

2002 • 255 citations

Interaction of Ihh and BMP/Noggin Signaling during Cartilage Differentiation

1999 • 235 citations

Assessment of Interobserver Variability and Histologic Parameters to Improve Reliability in Classification and Grading of Central Cartilaginous Tumors

2008 • 233 citations

Cartilaginous Tumors: Fast Contrast-enhanced MR Imaging

2000 • 216 citations

Multiple osteochondromas: mutation update and description of the multiple osteochondromas mutation database (MOdb)

2009 • 192 citations

Usefulness of radiography in differentiating enchondroma from central grade 1 chondrosarcoma.

1997 • 190 citations

EXT-Mutation Analysis and Loss of Heterozygosity in Sporadic and Hereditary Osteochondromas and Secondary Chondrosarcomas

1999 • 186 citations

Hypoxia induces HIF‐1α and VEGF expression in chondrosarcoma cells and chondrocytes

2004 • 181 citations

Reliability of Histopathologic and Radiologic Grading of Cartilaginous Neoplasms in Long Bones

2007 • 153 citations

Constitutive Hedgehog Signaling in Chondrosarcoma Up-Regulates Tumor Cell Proliferation

2006 • 153 citations

The Clinical Management of Chondrosarcoma

2009 • 146 citations

Up-Regulation of PTHrP and Bcl-2 Expression Characterizes the Progression of Osteochondroma towards Peripheral Chondrosarcoma and Is a Late Event in Central Chondrosarcoma

2000 • 143 citations

Correlation between clinicopathological features and karyotype in 100 cartilaginous and chordoid tumours. A report from the Chromosomes and Morphology (CHAMP) Collaborative Study Group

2001 • 141 citations

A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes

2009 • 123 citations

Regulation of Zebrafish Skeletogenesis by ext2/dackel and papst1/pinscher

2008 • 122 citations

Reliability of Histopathologic and Radiologic Grading of Cartilaginous Neoplasms in Long Bones

2007 • 119 citations

PTHR1 mutations associated with Ollier disease result in receptor loss of function

2008 • 114 citations

The Role of EXT1 in Nonhereditary Osteochondroma: Identification of Homozygous Deletions

2007 • 112 citations

Kinome Profiling of Chondrosarcoma Reveals Src-Pathway Activity and Dasatinib as Option for Treatment

2009 • 107 citations

Suberoylanilide hydroxamic acid (SAHA) induces apoptosis or autophagy-associated cell death in chondrosarcoma cell lines.

2008 • 107 citations

Chemotherapy and P‐glycoprotein expression in chondrosarcoma

1998 • 106 citations

Loss of heterozygosity and DNA ploidy point to a diverging genetic mechanism in the origin of peripheral and central chondrosarcoma

1999 • 102 citations

Absence of IHH and retention of PTHrP signalling in enchondromas and central chondrosarcomas

2005 • 94 citations

Central chondrosarcoma progression is associated with pRb pathway alterations: CDK4 down‐regulation and p16 overexpression inhibit cell growth in vitro

2008 • 88 citations

Molecular analysis of the INK4A/INK4A‐ARF gene locus in conventional (central) chondrosarcomas and enchondromas: indication of an important gene for tumour progression

2004 • 86 citations

CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression

2010 • 82 citations

Gains, losses, and amplifications of DNA sequences evaluated by comparative genomic hybridization in chondrosarcomas.

1997 • 82 citations

Radiologic Atlas of Bone Tumors.

1994 • 82 citations

Gli2 and p53 Cooperate to Regulate IGFBP-3- Mediated Chondrocyte Apoptosis in the Progression from Benign to Malignant Cartilage Tumors

2009 • 81 citations

Radiologic Atlas of Bone Tumors

1993 • 80 citations

2‐methoxyestradiol induces apoptosis and cell cycle arrest in human chondrosarcoma cells

2007 • 74 citations

Microvasculature and VEGF expression in cartilaginous tumors

2000 • 71 citations

Near-Haploidy and Subsequent Polyploidization Characterize the Progression of Peripheral Chondrosarcoma

2000 • 70 citations

Changes of the p16 gene but not the p53 gene in human chondrosarcoma tissues

2000 • 69 citations

Peripheral chondrosarcoma progression is accompanied by decreased Indian Hedgehog signalling

2006 • 69 citations

Decreased EXT expression and intracellular accumulation of heparan sulphate proteoglycan in osteochondromas and peripheral chondrosarcomas

2007 • 63 citations

Intrinsic radiation resistance in human chondrosarcoma cells

2006 • 61 citations

The Effects of Histone Deacetylase Inhibitors on the Induction of Differentiation in Chondrosarcoma Cells

2007 • 60 citations

Multidrug resistance‐1 and p‐glycoprotein in human chondrosarcoma cell lines: Expression correlates with decreased intracellular doxorubicin and in vitro chemoresistance

1999 • 60 citations

Tyrosine kinase inhibitor SU6668 represses chondrosarcoma growth via antiangiogenesis in vivo

2007 • 55 citations

Estrogen Signaling Is Active in Cartilaginous Tumors: Implications for Antiestrogen Therapy as Treatment Option of Metastasized or Irresectable Chondrosarcoma

2005 • 54 citations

cDNA expression profiling of chondrosarcomas: Ollier disease resembles solitary tumours and alteration in genes coding for components of energy metabolism occurs with increasing grade

2005 • 54 citations

Array‐comparative genomic hybridization of central chondrosarcoma

2006 • 54 citations

Correlation of hypoxic signalling to histological grade and outcome in cartilage tumours

2010 • 52 citations

Defective chondrocyte proliferation and differentiation in osteochondromas of MHE patients

2006 • 51 citations

siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells

2009 • 49 citations

siRNA mediated inhibition of MMP‐1 reduces invasive potential of a human chondrosarcoma cell line

2004 • 48 citations

Expression of hypoxia-inducible factor-1α and its relationship to tumour angiogenesis and cell proliferation in cartilage tumours

2008 • 47 citations

Aberrant Heparan Sulfate Proteoglycan Localization, Despite Normal Exostosin, in Central Chondrosarcoma

2009 • 47 citations

Suppression of chondrosarcoma cells by 15-deoxy-Δ12,14-prostaglandin J2 is associated with altered expression of Bax/Bcl-xL and p21

2005 • 46 citations

Chromosome 9 Alterations and Trisomy 22 in Central Chondrosarcoma: A Cytogenetic and DNA Flow Cytometric Analysis of Chondrosarcoma Subtypes

2001 • 44 citations

Inhibitory effects of a new bisphosphonate, minodronate, on proliferation and invasion of a variety of malignant bone tumor cells

2006 • 44 citations

COX-2 expression in chondrosarcoma: A role for celecoxib treatment?

2009 • 42 citations

Induction of MDM2-P2 Transcripts Correlates with Stabilized Wild-Type p53 in Betel- and Tobacco-Related Human Oral Cancer

2000 • 41 citations

Trail-induced apoptosis and interaction with cytotoxic agents in soft tissue sarcoma cell lines

2003 • 40 citations

Differential expression of VEGF‐A and angiopoietins in cartilage tumors and regulation by interleukin‐1β

2006 • 37 citations

Angiogenic Cytokines in Cartilage Tumors

2002 • 37 citations

Consequences of Telomerase Inhibition by BIBR1532 on Proliferation and Chemosensitivity of Chondrosarcoma Cell Lines

2008 • 37 citations

Tenascin-C promotes cell survival by activation of Akt in human chondrosarcoma cell

2005 • 36 citations

Alterations in the regulatory pathway involving p16, pRb and cdk4 in human chondrosarcoma

2001 • 35 citations

Developmental Pathways in Musculoskeletal Neoplasia: Involvement of the Indian Hedgehog-Parathyroid Hormone-Related Protein Pathway

2003 • 31 citations

P-glycoprotein expression in cartilaginous tumors

1997 • 30 citations

Alendronate inhibits cell invasion and MMP-2 secretion in human chondrosarcoma cell line

2007 • 27 citations

PTEN Mutation Is Rare in Chondrosarcoma

2002 • 25 citations

Monoclonal antibody to parathyroid hormone-related protein induces differentiation and apoptosis of chondrosarcoma cells

2003 • 22 citations

Suppression of chondrosarcoma cells by 15-deoxy-Δ12,14-prostaglandin J2 is associated with altered expression of Bax/Bcl-xL and p21

2005 • 6 citations

Parathyroid Hormone‐Related Protein Regulates Glioma‐Associated Oncogene Transcriptional Activation

2008 • 5 citations

Vault particles watch over dendritic cells

2001 • 1 citations