Induction of MDM2-P2 Transcripts Correlates with Stabilized Wild-Type p53 in Betel- and Tobacco-Related Human Oral Cancer

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

1991 • 712 citations

Interaction between the retinoblastoma protein and the oncoprotein MDM2

1995 • 592 citations

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

1993 • 565 citations

p53 Mutation and MDM2 amplification in human soft tissue sarcomas.

1993 • 535 citations

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

1995 • 459 citations

Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.

1993 • 332 citations

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential.

1994 • 325 citations

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth.

1993 • 321 citations

The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes.

1994 • 300 citations

Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: Transforming ability and frequent detection in human cancer

1996 • 272 citations

A functional p53-responsive intronic promoter is contained within the humanmdm2gene

1995 • 271 citations

Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein.

1997 • 208 citations

Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes.

1993 • 193 citations

The MDM2 Oncoprotein Binds Specifically to RNA through its RING Finger Domain

1996 • 170 citations

Physical and functional interaction between wild-type p53 and mdm2 proteins.

1994 • 135 citations

Overexpression of MDM2, due to enhanced translation, results in inactivation of wild-type p53 in Burkitt's lymphoma cells

1998 • 127 citations

The Ribosomal L5 Protein Is Associated with mdm-2 and mdm-2-p53 Complexes

1994 • 106 citations

The mdm-2 Oncogene Can Overcome Wild-Type p53 Suppression of Transformed Cell Growth

1993 • 84 citations

The MDM2 C-terminal Region Binds to TAFII250 and Is Required for MDM2 Regulation of the Cyclin A Promoter

1997 • 83 citations

Oral cancer : detection of patients and lesions at risk

1991 • 79 citations

MDM2/p53 co-expression in oral premalignant and malignant lesions: potential prognostic implications

1999 • 75 citations

Mutations and polymorphisms in thep53, p21 andp16 genes in oral carcinomas of Indian betel quid chewers

1996 • 69 citations

p53 gene mutations in oral carcinomas from India

1996 • 57 citations

A MOLECULAR AND IMMUNOHISTOCHEMICAL STUDY OF THE MDM2 PROTEIN ISOFORMS ANDp53 GENE PRODUCT IN BRONCHOGENIC CARCINOMA

1996 • 45 citations

Physical and Functional Interaction between Wild-Type p53 and mdm2 Proteins

1994 • 41 citations

MDM-2 protein is expressed in different layers of normal human skin

1997 • 24 citations

The P53-MDM2 Interaction in a Cancer-Prone Family, and the Identification of a Novel Therapeutic Target

1996 • 24 citations

Selective compartmentalization of different mdm2 proteins within the nucleus.

1994 • 13 citations