Studies of the mechanism of cytolysis by tumour-infiltrating lymphocytes

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Rapid colorimetric assay for cell growth and survival

1986 • 4,672 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Use of Tumor-Infiltrating Lymphocytes and Interleukin-2 in the Immunotherapy of Patients with Metastatic Melanoma

1988 • 2,196 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

Model Predicting Survival in Stage I Melanoma Based on Tumor Progression

1989 • 1,235 citations

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 • 1,073 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

Purification and characterization of the Fas-ligand that induces apoptosis.

1994 • 521 citations

Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression

1998 • 449 citations

Lymphocyte-mediated cytotoxicity: Two pathways and multiple effector molecules

1994 • 414 citations

Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity.

1994 • 386 citations

Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human glioma cells. Induction and modulation of sensitivity by cytokines.

1994 • 361 citations

TUMOUR-INFILTRATING LYMPHOCYTES AND INTERLEUKIN-2 IN TREATMENT OF ADVANCED CANCER

1989 • 337 citations

Differential ability of T_h1 and T_h2 T cells to express Fas ligand and to undergo activation-induced cell death

1994 • 329 citations

Autologous tumor-specific cytotoxic T lymphocytes in the infiltrate of human metastatic melanomas. Activation by interleukin 2 and autologous tumor cells, and involvement of the T cell receptor.

1988 • 324 citations

Tumor infiltrating lymphocytes in lymph node melanoma metastases: a histopathologic prognostic indicator and an expression of local immune response.

1996 • 319 citations

The Binding and Lysis of Target Cells by Cytotoxic Lymphocytes: Molecular and Cellular Aspects

1994 • 312 citations

Participation of target Fas protein in apoptosis pathway induced by CD4+ Th1 and CD8+ cytotoxic T cells.

1994 • 309 citations

Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells.

1995 • 293 citations

T cell receptor‐induced Fas ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A

1994 • 206 citations

TCR/CD3 coupling to Fas-based cytotoxicity.

1995 • 196 citations

LYMPHOCYTIC INFILTRATION IN GLIOMAS: EVIDENCE OF POSSIBLE HOST RESISTANCE

1971 • 170 citations

CD40 Ligand Induces an Antileukemia Immune Response In Vivo

1997 • 142 citations

Clonal and frequency analyses of tumor-infiltrating T lymphocytes from human solid tumors.

1987 • 130 citations

Clonal analysis of cytotoxic and regulatory T cell responses against human melanoma.

1989 • 130 citations

A Multivariate Analysis of Prognostic Factors for Melanoma Patients with Lesions > 3.65 mm in Thickness The Importance of Revealing Alternative Cox Models*

1982 • 129 citations

Evidence for in situ amplification of cytotoxic T-lymphocytes with antitumor activity in a human regressive melanoma.

1993 • 121 citations

Mechanisms of lysis by cytotoxic T lymphocyte clones. Lytic activity and gene expression in cloned antigen-specific CD4+ and CD8+ T lymphocytes.

1991 • 105 citations

Cytotoxic T-lymphocyte clones from different patients display limited T-cell-receptor variable-region gene usage in HLA-A2-restricted recognition of the melanoma antigen Melan-A/MART-1.

1995 • 104 citations

Expression and function of the FAS antigen in B chronic lymphocytic leukemia and hairy cell leukemia.

1995 • 102 citations

Functional characterization of T lymphocytes propagated from human lung carcinomas

1986 • 100 citations

T cell receptor (TCR) structure of autologous melanoma-reactive cytotoxic T lymphocyte (CTL) clones: tumor-infiltrating lymphocytes overexpress in vivo the TCR beta chain sequence used by an HLA-A2-restricted and melanocyte-lineage-specific CTL clone.

1993 • 98 citations

Characterization of a suppressor T-cell chronic lymphocytic leukemia with ADCC but not NK activity

1980 • 96 citations

Transgenic Expression of Fas in T Cells Blocks Lymphoproliferation But Not Autoimmune Disease in MRL-lprMice

1998 • 77 citations

Expression of cell adhesion molecules in human melanoma cell lines and their role in cytotoxicity mediated by tumor‐infiltrating lymphocytes

1992 • 71 citations

Helper and suppressor-inducer activity of human T cells and their cloned progeny maintained in long-term culture.

1981 • 65 citations

T-cell recognition of ovarian cancer.

1993 • 63 citations

Expression of HLA-A2 antigen in human melanoma cell lines and its role in T-cell recognition.

1991 • 63 citations

Selective expansion of a specific anti‐tumor CD8⁺ cytotoxic T lymphocyte clone in the bulk culture of tumor‐infiltrating lymphocytes from a melanoma patient: Cytotoxic activity and T cell receptor gene rearrangements

1990 • 58 citations

Regulation of Fas(Apo‐1/CD95)‐ and perforinmediated lytic pathways of primary cytotoxic T lymphocytes by the protooncogene bcl‐2

1995 • 56 citations

Evidence for T-cell clonal expansion in a patient with squamous cell carcinoma of the head and neck.

1994 • 56 citations

Target cell-induced apoptosis of interleukin-2-activated human natural killer cells: roles of cell surface molecules and intracellular events

1996 • 56 citations

CD4⁺ T cell‐mediated killing of major histocompatibility complex class II‐positive antigen‐presenting cells (APC) III. CD4⁺ cytotoxic T cells induce apoptosis of APC

1992 • 53 citations

Tumor Necrosis Factor-α-induced Cell Killing and Activation of Transcription Factor NF-κB Are Uncoupled in L929 Cells

1998 • 45 citations

Studies of the mechanism of cytolysis by HIV-1-specific CD4+ human CTL clones induced by candidate AIDS vaccines.

1994 • 43 citations

In vivoaccumulation of the same anti-melanoma T cell clone in two different metastatic sites

1997 • 41 citations

Cytolytic effector mechanisms of human CD4+ cytotoxic T lymphocytes

1996 • 39 citations

Metabolic inhibitors distinguish cytolytic activity of CD4 and CD8 clones

1990 • 37 citations

Human autologous tumor-specific T cells in malignant melanoma

1991 • 37 citations

Characterization of the CD4+ and CD8+ tumor infiltrating lymphocytes propagated with bispecific monoclonal antibodies.

1989 • 34 citations

bcl-2 protects against Fas-based but not perforin-based T cell-mediated cytolysis

1996 • 34 citations

The cytotoxic process of CD4 Th1 clones.

1992 • 32 citations

Apoptosis and T‐Cell Repertoire Selection in the Thymus

1992 • 27 citations

Clonal deletion of major histocompatibility complex class I‐restricted CD4⁺CD8⁺ thymocytes in vitro is independent of the CD95 (APO‐1/Fas) ligand

1995 • 21 citations

Two Types of Anti-TL (Thymus Leukemia) CTL Clones with Distinct Target Specificities: Differences in Cytotoxic Mechanisms and Accessory Molecule Requirements

1998 • 20 citations

Altered peptide ligands trigger perforin- rather than Fas-dependent cell lysis.

1997 • 16 citations

The Binding And Lysis of Target Cells by Cytotoxic Lymphocytes: Molecular and Cellular Aspects

1994 • 16 citations

Selective usage of TCR V beta in tumor-specific CTL lines isolated from ovarian tumor-associated lymphocytes.

1991 • 12 citations

T cell receptor gene rearrangements and cytotoxic activities of clones isolated from tumour-infiltrating lymphocytes (TIL) from melanoma patients

1994 • 8 citations

Variations in the Encephalitogenic Power of Vaccinia Virus

1932 • 7 citations

An Anergic Cytotoxic T Lymphocyte Clone Exhibits Granule Exocytosis-Mediated Cytotoxicity

1998 • 2 citations