The nootropic compound BMY-21502 improves spatial learning ability in brain injured rats

LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS

1957 • 7,145 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Developments of a water-maze procedure for studying spatial learning in the rat

1984 • 6,896 citations

Place navigation impaired in rats with hippocampal lesions

1982 • 6,277 citations

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus

1986 • 1,978 citations

The Role of Excitatory Amino Acids and NMDA Receptors in Traumatic Brain Injury

1989 • 1,505 citations

Glutamate neurotoxicity in cortical cell culture

1987 • 1,400 citations

Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain

1985 • 1,294 citations

Mechanisms of Memory

1986 • 1,252 citations

NMDA receptors - their role in long-term potentiation

1987 • 1,177 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path

1973 • 1,140 citations

Traumatic brain injury in the rat: Characterization of a lateral fluid-percussion model

1989 • 1,126 citations

The hippocampus and behavior.

1967 • 1,118 citations

Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury

1990 • 1,080 citations

A fluid percussion model of experimental brain injury in the rat

1987 • 1,031 citations

Anatomical organization of excitatory amino acid receptors and their pathways

1987 • 877 citations

Activation of the hippocampus in normal humans: a functional anatomical study of memory.

1992 • 853 citations

Hippocampal connections and spatial discrimination

1978 • 836 citations

Cerebral Blood Flow and Metabolism

1994 • 779 citations

Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D- aspartate receptor antagonist AP5

1989 • 766 citations

Selective vulnerability of dentate hilar neurons following traumatic brain injury: a potential mechanistic link between head trauma and disorders of the hippocampus

1992 • 680 citations

INTRACEREBRAL HÆMORRHAGE

1976 • 652 citations

Dynamic changes in local cerebral glucose utilization following cerebral concussion in rats: evidence of a hyper- and subsequent hypometabolic state

1991 • 571 citations

DELAYED RECOVERY OF INTELLECTUAL FUNCTION AFTER MINOR HEAD INJURY

1974 • 554 citations

The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro

1992 • 545 citations

Anatomical distributions of four pharmacologically distinct 3H-L-glutamate binding sites

1983 • 522 citations

Changes in Cortical Extracellular Levels of Energy-Related Metabolites and Amino Acids following Concussive Brain Injury in Rats

1990 • 521 citations

Persisting symptoms after mild head injury: A review of the postconcussive syndrome

1986 • 452 citations

Experimental fluid percussion brain injury: vascular disruption and neuronal and glial alterations

1989 • 450 citations

Moderate Head Injury: Completing the Clinical Spectrum of Brain Trauma

1982 • 438 citations

Long-Term Synaptic Potentiation

1988 • 417 citations

Prolonged memory impairment in the absence of hippocampal cell death following traumatic brain injury in the rat

1990 • 411 citations

Long-term potentiation as a candidate mnemonic device

1984 • 375 citations

Mild Experimental Brain Injury in the Rat Induces Cognitive Deficits Associated with Regional Neuronal Loss in the Hippocampus

1993 • 359 citations

Evaluation of Memory Dysfunction Following Experimental Brain Injury Using the Morris Water Maze

1991 • 352 citations

Cognitive Deficits Following Traumatic Brain Injury Produced by Controlled Cortical Impact

1992 • 348 citations

Fluid-percussion model of mechanical brain injury in the cat

1976 • 343 citations

Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.

1990 • 303 citations

SEQUELÆ OF CONCUSSION CAUSED BY MINOR HEAD INJURIES

1977 • 300 citations

Subtle Neuropsychological Deficits in Patients with Good Recovery after Closed Head Injury

1985 • 297 citations

Alzheimerʼs Disease. A Report of Progress in Research

1983 • 255 citations

Administration of Excitatory Amino Acid Antagonists via Microdialysis Attenuates the Increase in Glucose Utilization Seen following Concussive Brain Injury

1992 • 249 citations

Excitatory amino acid receptor subtype binding following traumatic brain injury

1990 • 138 citations

Selective Vulnerability of Hippocampal Neurons in Acceleration-Induced Experimental Head Injury

1991 • 117 citations

MEMORY AND HEAD INJURY

1972 • 114 citations

Long-term potentiation is associated with increased [3H]AMPA binding in rat hippocampus

1992 • 104 citations

Nootropic Drugs Positively Modulate α‐Amino‐3‐Hydroxy‐5‐Methyl‐4‐Isoxazolepropionic Acid‐Sensitive Glutamate Receptors in Neuronal Cultures

1992 • 94 citations

Aniracetam augments, and midazolam inhibits, the long-term potentiation in guinea-pig hippocampal slices

1986 • 93 citations

Evaluation of a novel calcium channel blocker, (S)-emopamil, on regional cerebral edema and neurobehavioral function after experimental brain injury

1992 • 81 citations

Production and Distribution of Intracranial and Intraspinal Pressure Changes at Sudden Extradural Fluid Volume Input in Rabbits

1969 • 64 citations

Regional Rates of Glucose Utilization in the Cat Following Concussive Head Injury

1988 • 54 citations

Receptor changes and LTP: An analysis using aniracetam, a drug that reversibly modifies glutamate (AMPA) receptors

1992 • 50 citations

The clinical use of piracetam, a new nootropic drug. The treatment of symptoms of senile involution.

1972 • 47 citations

Short-Term Recognition Memory in Relation to Severity of Head Injury

1976 • 39 citations

The action of piracetam on the electrical activity of the hippocampal slice preparation: A field potential analysis

1982 • 34 citations

Learning in post-traumatic amnesia following extremely severe closed head injury

1991 • 23 citations

Placebo-controlled study of pramiracetam in young males with memory and cognitive problems resulting from head injury and anoxia

1991 • 19 citations

Cerebral Concussion Suppresses Hippocampal Long-term Potentiation (LTP) in Rats

1989 • 15 citations

Intracranial Pressure VII

1990 • 13 citations

Effect of BMY 21502 on acquisition of shape discrimination and memory retention in monkey

1990 • 10 citations

A 1-heteroaryl-4-piperidinyl-methyl pyrrolidinone, BMY 21502, delays the decay of hippocampal synaptic potentiation in vitro

1990 • 9 citations

Effects of Focal Cortical Freezing Lesion on Regional Energy Metabolism

1991 • 9 citations

Effects of oral BMY 21502 on Morris water task performance in 16–18 month old F-344 rats

1992 • 8 citations