Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers

The Hallmarks of Cancer

2000 • 27,569 citations

Fibroblasts in cancer

2006 • 4,177 citations

Symptomatic Gastroesophageal Reflux as a Risk Factor for Esophageal Adenocarcinoma

1999 • 3,031 citations

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

2009 • 2,670 citations

IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

2004 • 2,361 citations

Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice

2007 • 1,140 citations

Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement

2009 • 690 citations

Incidence of Adenocarcinoma of the Esophagus Among White Americans by Sex, Stage, and Age

2008 • 683 citations

The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells

2004 • 650 citations

Gene expression profiling of the tumor microenvironment during breast cancer progression

2009 • 602 citations

Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility.

2002 • 541 citations

Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer.

2003 • 540 citations

Transcriptome Profile of Human Colorectal Adenomas

2007 • 473 citations

Diversity in the oesophageal phenotypic response to gastro-oesophageal reflux: immunological determinants

2002 • 259 citations

Distinctive patterns of gene expression in premalignant gastric mucosa and gastric cancer.

2003 • 219 citations

The gene associated with trichorhinophalangeal syndrome in humans is overexpressed in breast cancer

2005 • 218 citations

IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-β, NF-κB, and AP-1 activation

2007 • 210 citations

The Combination of Genetic Instability and Clonal Expansion Predicts Progression to Esophageal Adenocarcinoma

2004 • 190 citations

Transcriptome analysis of microdissected pancreatic intraepithelial neoplastic lesions

2005 • 189 citations

Interleukin 6: a fibroblast-derived growth inhibitor of human melanoma cells from early but not advanced stages of tumor progression.

1992 • 168 citations

Progression of Barrett's Metaplasia to Adenocarcinoma Is Associated with the Suppression of the Transcriptional Programs of Epidermal Differentiation

2005 • 161 citations

Epidemiologic risk factors for Barrett’s esophagus and associated adenocarcinoma

2005 • 146 citations

Gene Expression Profiling Reveals Stromal Genes Expressed in Common Between Barrett’s Esophagus and Adenocarcinoma

2006 • 145 citations

Transcriptional profiling suggests that Barrett's metaplasia is an early intermediate stage in esophageal adenocarcinogenesis

2006 • 118 citations

All in the Stroma: Cancer's Cosa Nostra

2008 • 74 citations

The proto-oncogene Bcl6 inhibits apoptotic cell death in differentiation-induced mouse myogenic cells

1999 • 71 citations

Cyclin A Immunocytology as a Risk Stratification Tool for Barrett's Esophagus Surveillance

2007 • 70 citations

Impaired transforming growth factor signalling in Barrett's carcinogenesis due to frequent SMAD4 inactivation

2005 • 62 citations

A pro-inflammatory genotype predisposes to Barrett's esophagus

2008 • 46 citations

Translationally regulated C/EBPβ isoform expression upregulates metastatic genes in hormone‐independent prostate cancer cells

2008 • 31 citations

Selective Loss of TGFβ Smad-Dependent Signalling Prevents Cell Cycle Arrest and Promotes Invasion in Oesophageal Adenocarcinoma Cell Lines

2007 • 27 citations

IL-6-induced Bcl6 variant 2 supports IL-6-dependent myeloma cell proliferation and survival through STAT3

2005 • 25 citations