Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene.

Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by¹³C Nuclear Magnetic Resonance Spectroscopy

1990 • 1,226 citations

Facilitative glucose transporters

1994 • 1,103 citations

Mechanisms of fatty acid-induced inhibition of glucose uptake.

1994 • 1,049 citations

Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance.

1989 • 799 citations

Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats.

1987 • 792 citations

Identification of a novel gene encoding an insulin-responsive glucose transporter protein

1989 • 601 citations

Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue.

1993 • 510 citations

Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4

1995 • 478 citations

Dose-response curves for in vivo insulin sensitivity in individual tissues in rats

1985 • 410 citations

A glucose transport protein expressed predominately in insulin-responsive tissues.

1989 • 394 citations

31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus.

1992 • 324 citations

Evidence Against Altered Expression of GLUT1 or GLUT4 in Skeletal Muscle of Patients With Obesity or NIDDM

1990 • 322 citations

Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus.

1995 • 316 citations

Variations in Insulin-Stimulated Glucose Uptake in Healthy Individuals with Normal Glucose Tolerance*

1987 • 311 citations

Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus.

1992 • 301 citations

Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs.

1996 • 290 citations

Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle

1993 • 281 citations

The Metabolic Profile of NIDDM Is Fully Established in Glucose-Tolerant Offspring of Two Mexican-American NIDDM Parents

1992 • 274 citations

Free Fatty Acid as a Link in the Regulation of Hepatic Glucose Output by Peripheral Insulin

1995 • 259 citations

Relative contribution of glycogen synthesis and glycolysis to insulin-mediated glucose uptake. A dose-response euglycemic clamp study in normal and diabetic rats.

1990 • 258 citations

Glucose Transport: Pivotal Step in Insulin Action

1996 • 249 citations

High-Fat Feeding Impairs Insulin-Stimulated GLUT4 Recruitment via an Early Insulin-Signaling Defect

1997 • 228 citations

Glycemic improvement in diabetic db/db mice by overexpression of the human insulin-regulatable glucose transporter (GLUT4).

1995 • 220 citations

Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non-insulin-dependent diabetes mellitus.

1995 • 210 citations

Enhanced Insulin Action Due to Targeted GLUT4 Overexpression Exclusively in Muscle

1996 • 191 citations

Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes.

1993 • 191 citations

Intracellular glucose oxidation and glycogen synthase activity are reduced in non-insulin-dependent (type II) diabetes independent of impaired glucose uptake.

1990 • 187 citations

Roles of Glucose Transport and Glucose Phosphorylation in Muscle Insulin Resistance of NIDDM

1996 • 180 citations

Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression.

1991 • 172 citations

Overexpression of Glut4 protein in muscle increases basal and insulin-stimulated whole body glucose disposal in conscious mice.

1995 • 168 citations

Decreased in vivo glucose uptake but normal expression of GLUT1 and GLUT4 in skeletal muscle of diabetic rats.

1991 • 167 citations

Skeletal Muscle Glucose Transport and Metabolism Are Enhanced in Transgenic Mice Overexpressing the Glut4 Glucose Transporter

1995 • 166 citations

Characterization of cellular defects of insulin action in type 2 (non-insulin-dependent) diabetes mellitus.

1993 • 164 citations

Insulin Induces the Translocation of GLUT4 From a Unique Intracellular Organelle to Transverse Tubules in Rat Skeletal Muscle

1992 • 164 citations

Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non-insulin dependent diabetes mellitus.

1991 • 154 citations

Transmembrane glucose transport in skeletal muscle of patients with non-insulin-dependent diabetes.

1993 • 152 citations

Peripheral effects of insulin dominate suppression of fasting hepatic glucose production

1990 • 149 citations

Animal Model for Maturity-onset Diabetes of the Young Generated by Disruption of the Mouse Glucokinase Gene

1995 • 135 citations

Insulin resistance in Type 2 (non-insulin-dependent) diabetic patients and their relatives is not associated with a defect in the expression of the insulin-responsive glucose transporter (GLUT-4) gene in human skeletal muscle

1992 • 120 citations

Germline manipulation of glucose homeostasis via alteration of glucose transporter levels in skeletal muscle.

1993 • 119 citations

Correction of chronic hyperglycemia with vanadate, but not with phlorizin, normalizes in vivo glycogen repletion and in vitro glycogen synthase activity in diabetic skeletal muscle.

1989 • 117 citations

Insulin unmasks a COOH-terminal Glut4 epitope and increases glucose transport across T-tubules in skeletal muscle.

1996 • 117 citations

Functional expression of insulin receptor substrate-1 is required for insulin-stimulated mitogenic signaling.

1993 • 116 citations

Hepatic Glucose Production Is Regulated Both by Direct Hepatic and Extrahepatic Effects of Insulin in Humans

1996 • 114 citations

Improvement of Insulin Action in Diabetic Transgenic Mice Selectively Overexpressing GLUT4 in Skeletal Muscle

1996 • 110 citations

Transgenic mice expressing the human GLUT4/muscle-fat facilitative glucose transporter protein exhibit efficient glycemic control.

1993 • 107 citations

Enhanced peripheral glucose utilization in transgenic mice expressing the human GLUT4 gene.

1994 • 101 citations

A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity.

1994 • 97 citations

Glucose transport activity in skeletal muscles from transgenic mice overexpressing GLUT1. Increased basal transport is associated with a defective response to diverse stimuli that activate GLUT4

1994 • 96 citations

Insulin Resistance in Microalbuminuric Hypertension

1995 • 90 citations

Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus.

1991 • 90 citations

The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents

1992 • 90 citations

Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs.

1992 • 88 citations

Predominant role of gluconeogenesis in the hepatic glycogen repletion of diabetic rats.

1992 • 87 citations

Glycaemia regulates the glucose transporter number in the plasma membrane of rat skeletal muscle

1992 • 80 citations

Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin

1995 • 79 citations

NMR studies of muscle glycogen synthesis in insulin-resistant offspring of parents with non-insulin-dependent diabetes mellitus immediately after glycogen-depleting exercise.

1996 • 76 citations

Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM

1990 • 76 citations

Diverse effects of Glut 4 ablation on glucose uptake and glycogen synthesis in red and white skeletal muscle.

1996 • 75 citations

Expression of the major insulin regulatable glucose transporter (GLUT4) in skeletal muscle of noninsulin-dependent diabetic patients and healthy subjects before and after insulin infusion.

1993 • 72 citations

Hyperglycaemia compensates for the defects in insulin-mediated glucose metabolism and in the activation of glycogen synthase in the skeletal muscle of patients with Type 2 (non-insulin-dependent) diabetes mellitus

1992 • 68 citations

Lilly lecture 1995. Glucose transport: pivotal step in insulin action

1996 • 68 citations

Skeletal muscle glycogenolysis is more sensitive to insulin than is glucose transport/phosphorylation. Relation to the insulin-mediated inhibition of hepatic glucose production.

1993 • 60 citations

Level of skeletal muscle glucose transporter protein correlates with insulin-stimulated whole body glucose disposal in man

1991 • 60 citations

Skeletal Muscle Glucose Transport and Metabolism Are Enhanced in Transgenic Mice Overexpressing the Glut4 Glucose Transporter.

1995 • 60 citations

Multiple defects of both hepatic and peripheral intracellular glucose processing contribute to the hyperglycaemia of NIDDM

1995 • 58 citations

High-fat feeding impairs insulin-stimulated GLUT4 recruitment via an early insulin-signaling defect

1997 • 54 citations

Hepatic Overexpression of Insulin-like Growth Factor-II in Adulthood Increases Basal and Insulin-stimulated Glucose Disposal in Conscious Mice

1996 • 51 citations

Dynamics of Hepatic and Peripheral Insulin Effects Suggest Common Rate-Limiting Step In Vivo

1993 • 48 citations

Roles of glucose transport and glucose phosphorylation in muscle insulin resistance of NIDDM

1996 • 45 citations

The effects of non-insulin-dependent diabetes mellitus on the kinetics of onset of insulin action in hepatic and extrahepatic tissues.

1995 • 44 citations

Effect of Insulin on Oxidation of Intracellularly and Extracellularly Derived Glucose in Patients With NIDDM: Evidence for Primary Defect in Glucose Transport and/or Phosphorylation but Not Oxidation

1990 • 38 citations

Enhanced insulin action due to targeted GLUT4 overexpression exclusively in muscle

1996 • 38 citations

Effect of insulin on GLUT-4 mRNA and protein concentrations in skeletal muscle of patients with NIDDM and their first-degree relatives

1994 • 37 citations

Insulin induces the translocation of GLUT4 from a unique intracellular organelle to transverse tubules in rat skeletal muscle

1992 • 37 citations

Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans

1996 • 36 citations

Isocratic high-performance liquid chromatographic determination of the concentration and specific radioactivity of phosphoenolpyruvate and uridine disphosphate glucose in tissue extracts

1989 • 33 citations

Hepatic and Extrahepatic Responses to Insulin in NIDDM and Nondiabetic Humans: Assessment in Absence of Artifact Introduced by Tritiated Nonglucose Contaminants

1990 • 32 citations

Facilitative glucose transporters

1994 • 30 citations

Quantitation of hepatic glucose fluxes and pathways of hepatic glycogen synthesis in conscious mice

1995 • 29 citations

Dynamics of hepatic and peripheral insulin effects suggest common rate-limiting step in vivo

1993 • 25 citations

Expression of the major insulin regulatable glucose transporter (GLUT4) in skeletal muscle of noninsulin-dependent diabetic patients and healthy subjects before and after insulin infusion

1993 • 25 citations

Improvement of insulin action in diabetic transgenic mice selectively overexpressing GLUT4 in skeletal muscle

1996 • 24 citations

Effect of insulin on oxidation of intracellularly and extracellularly derived glucose in patients with NIDDM. Evidence for primary defect in glucose transport and/or phosphorylation but not oxidation

1990 • 14 citations

Hepatic and extrahepatic responses to insulin in NIDDM and nondiabetic humans. Assessment in absence of artifact introduced by tritiated nonglucose contaminants

1990 • 14 citations

Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus

1991 • 9 citations

Multiple defects of both hepatic and peripheral intracellular glucose processing contribute to the hyperglycaemia of NIDDM

1995 • 8 citations

Effect of insulin on GLUT-4 mRNA and protein concentrations in skeletal muscle of patients with NIDDM and their first-degree relatives

1994 • 4 citations

Cited By (0)

Loading...