Tumor lysate–specific cytotoxic T lymphocytes in multiple myeloma: promising effector cells for immunotherapy

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

The expanding universe of T-cell subsets: Th1, Th2 and more

1996 • 3,710 citations

Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells

1998 • 2,916 citations

A PROSPECTIVE, RANDOMIZED TRIAL OF AUTOLOGOUS BONE MARROW TRANSPLANTATION AND CHEMOTHERAPY IN MULTIPLE MYELOMA

2013 • 2,176 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.

1976 • 951 citations

Simultaneous Humoral and Cellular Immune Response against Cancer–Testis Antigen NY-ESO-1: Definition of Human Histocompatibility Leukocyte Antigen (HLA)-A2–binding Peptide Epitopes

1998 • 728 citations

Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in vivo tumor regression.

1995 • 552 citations

Tumor-Specific Idiotype Vaccines in the Treatment of Patients With B-Cell Lymphoma — Long-Term Results of a Clinical Trial

1997 • 464 citations

Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune responsesin vitroandin vivo

1998 • 457 citations

The Treatment of Multiple Myeloma

1994 • 409 citations

Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity.

1996 • 401 citations

Idiotype Vaccination Using Dendritic Cells After Autologous Peripheral Blood Stem Cell Transplantation for Multiple Myeloma—A Feasibility Study

1999 • 398 citations

Cancer vaccines based on the identification of genes encoding cancer regression antigens

1997 • 395 citations

Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes

1994 • 307 citations

Transfer of myeloma idiotype-specific immunity from an actively immunised marrow donor

1995 • 269 citations

Immunotherapy with Dendritic Cells Directed against Tumor Antigens Shared with Normal Host Cells Results in Severe Autoimmune Disease

2000 • 258 citations

Mutations in the Fas Antigen in Patients With Multiple Myeloma

1997 • 228 citations

Idiotype Immunization Combined With Granulocyte-Macrophage Colony-Stimulating Factor in Myeloma Patients Induced Type I, Major Histocompatibility Complex–Restricted, CD8- and CD4-Specific T-Cell Responses

1998 • 189 citations

Mutations in the Fas Antigen in Patients With Multiple Myeloma

1997 • 183 citations

Idiotope‐specific T cell clones that recognize syngeneic immunoglobulin fragments in the context of class II molecules

1986 • 178 citations

Selection for Drug Resistance Results in Resistance to Fas-Mediated Apoptosis

1997 • 165 citations

Idiotype Immunization Combined With Granulocyte-Macrophage Colony-Stimulating Factor in Myeloma Patients Induced Type I, Major Histocompatibility Complex–Restricted, CD8- and CD4-Specific T-Cell Responses

1998 • 161 citations

Idiotypic protein-pulsed dendritic cell vaccination in multiple myeloma

1999 • 160 citations

Diagnostic Criteria of Multiple Myeloma

1992 • 160 citations

Dendritic cells acquire the MAGE-3 human tumor antigen from apoptotic cells and induce a class I-restricted T cell response

2000 • 152 citations

Idiotype-specific cytotoxic T lymphocytes in multiple myeloma: evidence for their capacity to lyse autologous primary tumor cells

2001 • 133 citations

Idiotypic protein-pulsed adherent peripheral blood mononuclear cell-derived dendritic cells prime immune system in multiple myeloma.

1998 • 133 citations

T-cell subsets and cytokines in parasitic infections

1992 • 131 citations

Idiotype-reactive T-cell subsets and tumor load in monoclonal gammopathies

1995 • 117 citations

Modulation of anti‐idiotypic immune response by immunization with the autologous M‐component protein in multiple myeloma patients

1996 • 97 citations

Relapse of multiple myeloma after autologous transplantation: survival after salvage therapy.

1995 • 91 citations

Myeloma Bone Marrow Plasma Cells: Evidence for Their Capacity as Antigen-Presenting Cells

1997 • 78 citations

Plasma cell myeloma

2001 • 77 citations

Phenotypic analysis of human myeloma cell lines

1989 • 74 citations

T‐Cell Stimulation Induced by Idiotypes on Monoclonal Immunoglobulins in Patients with Monoclonal Gammopathies

1993 • 43 citations

Deletion of Idiotype (Id)-Specific T Cells in Multiple Myeloma

2000 • 27 citations

Myeloma‐reactive allospecific cytotoxic T lymphocytes lyse target cells via the granule exocytosis pathway

2001 • 19 citations