Secrets of the lac Operon

Biochemistry and molecular cell biology of diabetic complications

2001 • 8,707 citations

Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes

2005 • 4,969 citations

Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale

1997 • 4,531 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

2005 • 3,020 citations

Reactive oxygen species have a causal role in multiple forms of insulin resistance

2006 • 2,397 citations

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

2000 • 1,756 citations

Gene Expression Profile of Aging and Its Retardation by Caloric Restriction

1999 • 1,483 citations

The Endocrine Regulation of Aging by Insulin-like Signals

2003 • 1,342 citations

Rates of Behavior and Aging Specified by Mitochondrial Function During Development

2002 • 1,058 citations

Gene-expression profile of the ageing brain in mice

2000 • 1,057 citations

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

2002 • 1,051 citations

Epigenetic Regulation of Cellular Memory by the Polycomb and Trithorax Group Proteins

2004 • 1,049 citations

Multistability in the lactose utilization network of Escherichia coli

2004 • 1,043 citations

Diabetes and mitochondrial function: Role of hyperglycemia and oxidative stress

2006 • 972 citations

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

2002 • 944 citations

The genetics of caloric restriction in Caenorhabditis elegans

1998 • 918 citations

Molecular Physiology of the Regulation of Hepatic Gluconeogenesis and Glycolysis

1992 • 816 citations

Inhibition of Glycolysis in Cancer Cells: A Novel Strategy to Overcome Drug Resistance Associated with Mitochondrial Respiratory Defect and Hypoxia

2005 • 809 citations

A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm

1996 • 728 citations

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

2003 • 719 citations

Methionine‐deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF‐I and insulin levels, and increases hepatocyte MIF levels and stress resistance

2005 • 696 citations

Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake

2003 • 688 citations

A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes

1998 • 676 citations

Malonyl-CoA, fuel sensing, and insulin resistance

1999 • 655 citations

Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes

2004 • 640 citations

Glucokinase as Glucose Sensor and Metabolic Signal Generator in Pancreatic β-Cells and Hepatocytes

1990 • 603 citations

The Mitochondrial Production of Reactive Oxygen Species: Mechanisms and Implications in Human Pathology

2001 • 584 citations

Glucose repression in yeast

1999 • 573 citations

Low methionine ingestion by rats extends life span.

1993 • 547 citations

Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals

2000 • 536 citations

Determination of Life-Span in Caenorhabditis elegans by Four Clock Genes

1996 • 529 citations

New Genes Tied to Endocrine, Metabolic, and Dietary Regulation of Lifespan from a Caenorhabditis elegans Genomic RNAi Screen

2005 • 527 citations

Hypothalamic Pro-Opiomelanocortin mRNA Is Reduced By Fasting in ob/ob and db/db Mice, but Is Stimulated by Leptin

1998 • 518 citations

Calories Do Not Explain Extension of Life Span by Dietary Restriction in Drosophila

2005 • 509 citations

A systematic RNAi screen for longevity genes in C. elegans

2005 • 505 citations

Control of Mitochondrial Redox Balance and Cellular Defense against Oxidative Damage by Mitochondrial NADP+-dependent Isocitrate Dehydrogenase

2001 • 504 citations

Role of NADH Shuttle System in Glucose-Induced Activation of Mitochondrial Metabolism and Insulin Secretion

1999 • 465 citations

Glucose repression in fungi

1995 • 451 citations

Extending the lifespan of long-lived mice

2001 • 425 citations

Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

2003 • 417 citations

Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response

2002 • 417 citations

Overexpression of fibronectin induced by diabetes or high glucose: phenomenon with a memory.

1990 • 406 citations

Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys

2001 • 386 citations

Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart

2001 • 369 citations

Temporal order of chromatin structural changes associated with activation of the major chicken vitellogenin gene

1983 • 366 citations

The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach

1998 • 352 citations

Hypothalamic Proopiomelanocortin Neurons Are Glucose Responsive and Express K_ATPChannels

2003 • 341 citations

Central melanocortin receptors regulate insulin action

2001 • 335 citations

Enhanced Glutathione Levels and Oxidoresistance Mediated by Increased Glucose-6-phosphate Dehydrogenase Expression

1999 • 333 citations

An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness

2000 • 331 citations

Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities.

1998 • 324 citations

Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts

2002 • 312 citations

Dietary Restriction Alters Characteristics of Glucose Fuel Use

1992 • 304 citations

Dietary Restriction in Long-Lived Dwarf Flies

2002 • 292 citations

Glucokinase as pancreatic beta cell glucose sensor and diabetes gene.

1993 • 281 citations

Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut.

1994 • 279 citations

Hypothalamic glucose sensor: similarities to and differences from pancreatic beta-cell mechanisms.

1999 • 277 citations

Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria

2002 • 276 citations

Hypothesis

1985 • 272 citations

Metabolism at a glance

1993 • 267 citations

A Defect in the Cytochrome b Large Subunit in Complex II Causes Both Superoxide Anion Overproduction and Abnormal Energy Metabolism in Caenorhabditis elegans

2001 • 265 citations

The lac repressor

2005 • 257 citations

Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria

1998 • 253 citations

Molecular pathogenesis of Parkinson's disease

2005 • 247 citations

Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans

2003 • 243 citations

Involvement of Mitochondrial Complex II Defects in Neuronal Death Produced by N-Terminus Fragment of Mutated Huntingtin

2006 • 240 citations

Aging in vertebrates, and the effect of caloric restriction: a mitochondrial free radical production–DNA damage mechanism?

2004 • 229 citations

A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts

2004 • 217 citations

Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle

2000 • 215 citations

Does food restriction retard aging by reducing the metabolic rate?

1985 • 212 citations

Localization at complex I and mechanism of the higher free radical production of brain nonsynaptic mitochondria in the short-lived rat than in the longevous pigeon.

1998 • 204 citations

‘The Metabolism of Tumours’: 70 Years Later

2001 • 201 citations

Axenic growth up-regulates mass-specific metabolic rate, stress resistance, and extends life span in Caenorhabditis elegans

2002 • 201 citations

Progressive Accumulation of Mitochondrial DNA Mutations and Decline in Mitochondrial Function Lead to β-Cell Failure

2005 • 195 citations

A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants

2001 • 193 citations

Signatures of hippocampal oxidative stress in aged spatial learning-impaired rodents

2001 • 178 citations

Relationship between antioxidant defenses and longevity in different mammalian species

1990 • 175 citations

“Wages of Fear”: transient threefold decrease in intracellular ATP level imposes apoptosis

2004 • 172 citations

Failure to increase glucose consumption through the pentose-phosphate pathway results in the death of glucose-6-phosphate dehydrogenase gene-deleted mouse embryonic stem cells subjected to oxidative stress

2003 • 172 citations

Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long‐term caloric restriction

2003 • 170 citations

Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle

2002 • 170 citations

Localization of glucokinase gene expression in the rat brain.

2000 • 164 citations

Dietary Restriction at Old Age Lowers Mitochondrial Oxygen Radical Production and Leak at Complex I and Oxidative DNA Damage in Rat Brain

2005 • 160 citations

Elevated Glucose and Diabetes Promote Interleukin-12 Cytokine Gene Expression in Mouse Macrophages

2006 • 157 citations

Hypoglycemia-Associated Autonomic Failure in Insulin-Dependent Diabetes Mellitus

1997 • 155 citations

Enhanced expression of glucose-6-phosphate dehydrogenase in human cells sustaining oxidative stress

1997 • 155 citations

Dietary modulation of the progression of nephropathy in aging rats: an evaluation of the importance of protein

1989 • 154 citations

The Mammalian Longevity-associated Gene Product p66 Regulates Mitochondrial Metabolism

2006 • 153 citations

Localization of the site of oxygen radical generation inside the complex I of heart and nonsynaptic brain mammalian mitochondria.

2000 • 148 citations

Glucose as a regulator of eukaryotic gene transcription

2005 • 145 citations

Intermittent fasting and dietary supplementation with 2‐deoxy‐<scp>D</scp>‐glucose improve functional and metabolic cardiovascular risk factors in rats

2003 • 138 citations

Induction by Glucose of Genes Coding for Glycolytic Enzymes in a Pancreatic β-Cell Line (INS-1)

1997 • 135 citations

Influence of the Restriction of Individual Dietary Components on Longevity And Age-Related Disease of Fischer Rats: The Fat Component and the Mineral Component

1988 • 132 citations

Oxidative Stress: The Old Enemy in Alzheimers Disease Pathophysiology

2005 • 130 citations

The impact of α-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice

2004 • 129 citations

No reduction of metabolic rate in food restricted Caenorhabditis elegans

2002 • 129 citations

Caloric Restriction and Aging: Controversial Issues

2006 • 122 citations

Gerontogenes mediate health and longevity in nematodes through increasing resistance to environmental toxins and stressors

2000 • 120 citations

Mutations in amyloid precursor protein and presenilin‐1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid β‐peptide (1–42), H₂O₂ and kainic acid: implications for Alzheimer's disease

2006 • 115 citations

Hyperphagia and Weight Gain after Gold-Thioglucose: Relation to Hypothalamic Neuropeptide Y and Proopiomelanocortin**This work was supported by grants from the Children’s Hospital Research Foundation (to H.T.B.) and the NIH (DK-50110; to C.V.M.).

1998 • 114 citations

Influences of Age and Dietary Restriction on Gastrocnemius Electron Transport System Activities in Mice

1996 • 110 citations

Mitochondrial Oxidative Phosphorylation Is Defective in the Long-lived Mutant clk-1

2004 • 106 citations

Mitochondrial genotype associated with longevity and its inhibitory effect on mutagenesis

2000 • 104 citations

A Complex II Defect Affects Mitochondrial Structure, Leading to ced-3- and ced-4-dependent Apoptosis and Aging

2003 • 100 citations

Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells

2005 • 92 citations

The Effects of Hormone Replacement Therapy on Hypothalamic Neuropeptide Gene Expression in a Primate Model of Menopause¹

1999 • 92 citations

Transgenic Neuronal Expression of Proopiomelanocortin Attenuates Hyperphagic Response to Fasting and Reverses Metabolic Impairments in Leptin-Deficient Obese Mice

2003 • 84 citations

clk-1, mitochondria, and physiological rates

2000 • 82 citations

Hierarchy of Physiological Responses to Hypoglycemia: Relevance to Clinical Hypoglycemia in Type I (Insulin Dependent) Diabetes Mellitus*

1997 • 78 citations

Neuropeptide Y Is Required for Hyperphagic Feeding in Response to Neuroglucopenia

2004 • 77 citations

Caloric restriction augments ROS defense inS. cerevisiae, by a Sir2p independent mechanism

2004 • 76 citations

Influence of age and caloric restriction on liver glycolytic enzyme activities and metabolite concentrations in mice

2003 • 75 citations

No reduction of energy metabolism in Clk mutants

2002 • 69 citations

Hypoxia and Hypoxia Inducible Factors (HIF) as Important Regulators of Tumor Physiology

2004 • 60 citations

Presumed apoptosis and reduced arcuate nucleus neuropeptide Y and pro-opiomelanocortin mRNA in non-coma hypoglycemia.

2000 • 57 citations

Protein oxidation during aging of the nematode Caenorhabditis elegans

2002 • 57 citations

Counterregulatory deficits occur within 24 h of a single hypoglycemic episode in conscious, unrestrained, chronically cannulated mice

2006 • 50 citations

Food Restriction Enhances the Proteolytic Capacity of the Aging Rat Liver

1988 • 49 citations

Acute Induction of Gene Expression in Brain and Liver by Insulin-Induced Hypoglycemia

2005 • 48 citations

Proopiomelanocortin gene expression is decreased in the infundibular nucleus of postmenopausal women

1999 • 46 citations

Age-related decrease in proopiomelanocortin gene expression in the arcuate nucleus of the male rat brain

1991 • 43 citations

Age-Related Changes in Proopiomelanocortin Messenger Ribonucleic Acid Levels in Hypothalamus and Pituitary of Female C57BL/6 J Mice*

1988 • 43 citations

Stereologic study of the hypothalamic infundibular nucleus in young and older women

2000 • 40 citations

Age-Related Changes in Proopiomelanocortin (POMC) Gene Expression in the Periarcuate Region of Ovariectomized Rats

1991 • 33 citations

The role of glucose-6-phosphate dehydrogenase in the evolution of longevity in Drosophila melanogaster

1990 • 32 citations

Bistability and hysteresis in epigenetic regulation of the lactose operon. Since Delbrück, a long series of ignored models.

2005 • 30 citations

Mechanism of Polycomb Group Gene Silencing

2004 • 23 citations

Decreased ratio of fat to carbohydrate oxidation with increasing age in Pima Indians.

1996 • 23 citations

Essential biochemical design features of the fuel-sensing system in pancreatic β-cells

1997 • 22 citations

Genetic influences on glucose neurotoxicity, aging, and diabetes: A possible role for glucose hysteresis

1993 • 19 citations

Citric acid cycle: A mainstream metabolic pathway influencing life span in drosophila melanogaster?

1996 • 17 citations

Mining Microarrays for Metabolic Meaning: Nutritional Regulation of Hypothalamic Gene Expression

2004 • 17 citations

Modulation of NADP⁺-dependent isocitrate dehydrogenase in aging

2004 • 16 citations

Molecular hysteresis: Residual effects of hormones and glucose on genes during aging

1994 • 12 citations

Gene Memory in Neuroendocrine and Behavioural Systems

2007 • 3 citations