Sphingosine 1‐Phosphate: A Ligand for the EDG‐1 Family of G‐Protein‐Coupled Receptors

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

1997 • 1,215 citations

Anchorage dependence, integrins, and apoptosis

1994 • 1,016 citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex.

1996 • 727 citations

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.

1991 • 627 citations

Characterization of a Novel Subtype of Human G Protein-coupled Receptor for Lysophosphatidic Acid

1998 • 535 citations

Signal transduction through lipid second messengers

1996 • 496 citations

Lysophosphatidic acid: G-protein signalling and cellular responses

1997 • 492 citations

An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.

1990 • 474 citations

Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival

1998 • 468 citations

Sphingosine 1-Phosphate, a Bioactive Sphingolipid Abundantly Stored in Platelets, Is a Normal Constituent of Human Plasma and Serum

1997 • 442 citations

Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets

1995 • 435 citations

Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor.

1996 • 280 citations

Identification of cDNAs encoding two G protein‐coupled receptors for lysosphingolipids¹

1997 • 247 citations

Molecular Cloning of the Human Edg2 Protein and Its Identification as a Functional Cellular Receptor for Lysophosphatidic Acid

1997 • 232 citations

EDG6, a Novel G-Protein-Coupled Receptor Related to Receptors for Bioactive Lysophospholipids, Is Specifically Expressed in Lymphoid Tissue

1998 • 231 citations

Sphingosine‐1‐Phosphate in Cell Growth and Cell Death^a

1998 • 202 citations

Activation of a High Affinity Gi Protein-coupled Plasma Membrane Receptor by Sphingosine-1-phosphate

1996 • 197 citations

Sphingosine 1-Phosphate-induced Cell Rounding and Neurite Retraction Are Mediated by the G Protein-coupled Receptor H218

1999 • 183 citations

Ligand-induced Trafficking of the Sphingosine-1-phosphate Receptor EDG-1

1999 • 180 citations

Sphingosine 1-Phosphate Rapidly Activates the Mitogen-activated Protein Kinase Pathway by a G Protein-dependent Mechanism

1995 • 180 citations

Sphingosine 1-phosphate: a prototype of a new class of second messengers

1999 • 176 citations

Involvement of a Pertussis Toxin-sensitive G Protein in the Mitogenic Signaling Pathways of Sphingosine 1-Phosphate

1995 • 161 citations

Molecular Cloning of a Novel Putative G Protein-Coupled Receptor Expressed in the Cardiovascular System

1993 • 150 citations

Sphingosine 1-phosphate stimulates Rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts

1997 • 112 citations

Cloning and Characterization of a Putative G-Protein Coupled Receptor Potentially Involved in Development

1994 • 110 citations

Molecular Cloning of the Novel Human G Protein-Coupled Receptor (GPCR) Gene Mapped on Chromosome 9

1996 • 106 citations

Sphingosine 1-Phosphate Regulates Melanoma Cell Motility through a Receptor-Coupled Extracellular Action and in a Pertussis Toxin-Insensitive Manner

1997 • 78 citations

Exogenous Sphingosine 1-Phosphate Induces Neurite Retraction Possibly through a Cell Surface Receptor in PC12 Cells

1997 • 71 citations

Embryonic expression pattern of H218, a G-protein coupled receptor homolog, suggests roles in early mammalian nervous system development

1997 • 35 citations

Efficient synthesis of sphingosine-1-phosphonate and homo-sphingosine-1-phosphonate

1997 • 19 citations