The hypothalamic arcuate nucleus: A key site for mediating leptin’s effects on glucose homeostasis and locomotor activity

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

Obesity and the Regulation of Energy Balance

2001 • 2,387 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

2001 • 2,288 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 2,024 citations

Leptin Regulates Bone Formation via the Sympathetic Nervous System

2002 • 1,651 citations

The role of neuropeptide Y in the antiobesity action of the obese gene product

1995 • 1,521 citations

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

1978 • 1,274 citations

Trophic Action of Leptin on Hypothalamic Neurons That Regulate Feeding

2004 • 1,188 citations

From Lesions to Leptin

1999 • 1,165 citations

Obesity Wars

2004 • 1,119 citations

The Need to Feed

2002 • 1,089 citations

Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

1996 • 1,074 citations

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

1999 • 1,040 citations

Distributions of leptin receptor mRNA isoforms in the rat brain

1998 • 1,011 citations

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

2003 • 1,003 citations

Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin

2004 • 975 citations

Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area

1999 • 909 citations

Leptin Receptor Signaling in POMC Neurons Is Required for Normal Body Weight Homeostasis

2004 • 895 citations

Localization of leptin receptor mRNA and the long form splice variant (Ob‐Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization

1996 • 879 citations

Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in ob/ob Mice

1996 • 873 citations

Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

1997 • 837 citations

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.

1996 • 820 citations

Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of Neuropeptide Y

1996 • 814 citations

Genetics of body-weight regulation

2000 • 797 citations

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues

1997 • 771 citations

Acute stimulation of glucose metabolism in mice by leptin treatment

1997 • 717 citations

Selective deletion of leptin receptor in neurons leads to obesity

2001 • 562 citations

Selective deletion of leptin receptor in neurons leads to obesity

2001 • 533 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 425 citations

Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus

2004 • 416 citations

Minireview: From Anorexia to Obesity—The Yin and Yang of Body Weight Control

2003 • 385 citations

Hypothalamic Agouti-Related Protein Messenger Ribonucleic Acid Is Inhibited by Leptin and Stimulated by Fasting*

1999 • 374 citations

Modern science versus the stigma of obesity

2004 • 368 citations

Transgenic Mice Expressing Green Fluorescent Protein under the Control of the Melanocortin-4 Receptor Promoter

2003 • 362 citations

Is the Energy Homeostasis System Inherently Biased Toward Weight Gain?

2003 • 355 citations

Central melanocortin receptors regulate insulin action

2001 • 335 citations

Role of Signal Transducer and Activator of Transcription 3 in Regulation of Hypothalamic Proopiomelanocortin Gene Expression by Leptin

2003 • 320 citations

Central melanocortin receptors regulate insulin action

2001 • 317 citations

The Central Melanocortin System Can Directly Regulate Serum Insulin Levels*

2000 • 273 citations

Recombinant adeno-associated virus vector: use for transgene expression and anterograde tract tracing in the CNS

1998 • 219 citations

Brain Stem Is a Direct Target for Leptin’s Action in the Central Nervous System

2002 • 202 citations

Neuropeptide Y-Mediated Inhibition of Proopiomelanocortin Neurons in the Arcuate Nucleus Shows Enhanced Desensitization in ob/ob Mice

2004 • 197 citations

Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction

1999 • 172 citations

Arcuate Nucleus-Specific Leptin Receptor Gene Therapy Attenuates the Obesity Phenotype of Koletsky (fak/fak) Rats

2003 • 156 citations

Transgenic Complementation of Leptin-Receptor Deficiency

2001 • 150 citations

Electrophysiological Actions of Peripheral Hormones on Melanocortin Neurons

2003 • 118 citations

An allelic series for the leptin receptor gene generated by CRE and FLP recombinase

2004 • 81 citations

Effects of food restriction on the hypothalamic prepro-orexin gene expression in genetically obese mice

2000 • 65 citations