Modern science versus the stigma of obesity

Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance

2001 • 11,028 citations

Principles of neural science

1982 • 9,410 citations

Prevalence and Trends in Obesity Among US Adults, 1999-2000

2002 • 6,312 citations

Leptin and the regulation of body weight in mammals

1998 • 5,366 citations

Obesity as a medical problem

2000 • 4,948 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1995 • 3,730 citations

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

1998 • 3,700 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1997 • 2,900 citations

Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? 1962.

1999 • 2,323 citations

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 2,024 citations

Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

1999 • 1,959 citations

Changes in Energy Expenditure Resulting from Altered Body Weight

1995 • 1,926 citations

Principles of Neural Science

2014 • 1,891 citations

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

1998 • 1,666 citations

Leptin-regulated endocannabinoids are involved in maintaining food intake

2001 • 1,557 citations

Recombinant Leptin for Weight Loss in Obese and Lean Adults

1999 • 1,408 citations

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

2002 • 1,312 citations

The Response to Long-Term Overfeeding in Identical Twins

1990 • 1,287 citations

The Body-Mass Index of Twins Who Have Been Reared Apart

1990 • 1,283 citations

Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors

1995 • 1,264 citations

Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

2003 • 1,260 citations

Reduced Rate of Energy Expenditure as a Risk Factor for Body-Weight Gain

1988 • 1,210 citations

Leptin-Replacement Therapy for Lipodystrophy

2002 • 1,201 citations

Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance

1996 • 1,170 citations

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

1997 • 1,125 citations

Obesity Wars

2004 • 1,119 citations

Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice

1996 • 1,097 citations

The Need to Feed

2002 • 1,089 citations

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

2002 • 1,051 citations

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

1997 • 1,043 citations

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

1999 • 1,040 citations

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

1996 • 1,020 citations

Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans

1996 • 1,004 citations

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

2003 • 1,003 citations

Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

1998 • 1,000 citations

Role of Nonexercise Activity Thermogenesis in Resistance to Fat Gain in Humans

1999 • 998 citations

Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin

2004 • 975 citations

Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat

2000 • 885 citations

A Twin Study of Human Obesity

1986 • 872 citations

Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss

2002 • 825 citations

Genetics of body-weight regulation

2000 • 797 citations

Molecular characterization of the mouse agouti locus

1992 • 791 citations

PTP1B Regulates Leptin Signal Transduction In Vivo

2002 • 785 citations

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues

1997 • 771 citations

βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance

2002 • 768 citations

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

2002 • 694 citations

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

2002 • 588 citations

Key enzyme in leptin-induced anorexia

2001 • 574 citations

Dietary obesity in nine inbred mouse strains

1992 • 487 citations

Bariatric Surgery and Long-term Control of Morbid Obesity

2002 • 487 citations

Treatment of Obesity by Moderate and Severe Caloric Restriction: Results of Clinical Research Trials

1993 • 482 citations

Activation of Central Melanocortin Pathways by Fenfluramine

2002 • 481 citations

Diabetes mellitus · A

1975 • 462 citations

The heritability of body mass index among an international sample of monozygotic twins reared apart.

1996 • 422 citations

Modulation of Brain Reward Circuitry by Leptin

2000 • 411 citations

Virus-Assisted Mapping of Neural Inputs to a Feeding Center in the Hypothalamus

2001 • 407 citations

Partial leptin deficiency and human adiposity

2001 • 402 citations

A War on Obesity, Not the Obese

2003 • 371 citations

THE SPONTANEOUS ACTIVITY AND FOOD INTAKE OF RATS WITH HYPOTHALAMIC LESIONS

1942 • 316 citations

Body Mass Index and Mortality Among Nonsmoking Older Persons

1988 • 307 citations

A phosphatidylinositol 3-kinase–phosphodiesterase 3B–cyclic AMP pathway in hypothalamic action of leptin on feeding

2002 • 239 citations

Impaired transport of leptin across the blood-brain barrier in obesity is acquired and reversible

2003 • 230 citations

Minireview: Human Obesity—Lessons from Monogenic Disorders

2003 • 224 citations

Minireview: Nutrient Sensing and the Regulation of Insulin Action and Energy Balance

2003 • 217 citations

A Double-blind Clinical Trial in Weight Control

1984 • 205 citations

Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction

1999 • 172 citations

Long-term Pharmacotherapy of Obesity 2000

2001 • 171 citations

Appetite and the regulation of body composition

1994 • 156 citations

Effect of Leptin Replacement on Pituitary Hormone Regulation in Patients with Severe Lipodystrophy

2002 • 118 citations

Short- and Long-Term Changes in Serum Leptin in Dieting Obese Women: Effects of Caloric Restriction and Weight Loss¹

1998 • 116 citations

Obesity: historical development of scientific and cultural ideas.

1990 • 103 citations

A comparison of the effects on central 5‐HT function of sibutramine hydrochloride and other weight‐modifying agents

1998 • 101 citations

Absence of Soluble Leptin Receptor in Plasma fromdbPas/dbPas and Otherdb/db Mice

1998 • 80 citations

Hyperleptinemia Precipitates Diet-Induced Obesity in Transgenic Mice Overexpressing Leptin

2003 • 47 citations

Die Quelle der thierischen Wärme

1893 • 33 citations

Memoir on Heat Read to the Royal Academy of Sciences, 28 June 1783

1994 • 23 citations

Counting Calories—Caveat Emptor

1993 • 18 citations

Counting calories--caveat emptor

1993 • 18 citations

Memoir on Heat

1982 • 12 citations

Morbid Obesity: Perceptions of Character and Comorbidities in Falstaff

2000 • 4 citations