Functional analyses of mammalian protein kinase C isozymes in budding yeast and mammalian fibroblasts

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1988 • 1,351 citations

Laboratory course manual for methods in yeast genetics

1986 • 1,310 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

Molecular mechanisms of receptor desensitization using the β-adrenergic receptor-coupled adenylate cyclase system as a model

1985 • 732 citations

GAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits

1996 • 729 citations

Cloning and expression of multiple protein kinase C cDNAs

1986 • 683 citations

Genes to cells edited by Jun-ichi Tomizawa, Blackwell Science Ltd. Institutional: £218.00 (Europe), £242.00 (Rest of World), US$382.00 (USA and Canada). Individual: £65.00 (Europe), £72.00 (Rest of World), US$114.00 (USA and Canada) ISSN 1356 9597

1997 • 673 citations

RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits

1996 • 547 citations

Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity.

1993 • 546 citations

Overproduction of protein kinase C causesdisordered growth control in rat fibroblasts

1988 • 492 citations

G protein—coupled receptor kinases

1993 • 434 citations

A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin.

1990 • 434 citations

The yeast SCG1 gene: A Gα-like protein implicated in the a- and α-factor response pathway

1987 • 431 citations

A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle

1990 • 422 citations

A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C.

1993 • 373 citations

Mutants in the S. cerevisiae PKC1 gene display a cell cycle-specific osmotic stability defect.

1992 • 371 citations

GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction

1987 • 365 citations

RGS10 is a selective activator of Gαi GTPase activity

1996 • 354 citations

Nucleotide sequences of STE2 and STE3 , cell type-specific sterile genes from Saccharomyces cerevisiae

1985 • 351 citations

A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle.

1992 • 340 citations

Dominant Mutations in a Gene Encoding a Putative Protein Kinase (BCKT) Bypass the Requirement for a Saccharomyces cerevisiae Protein Kinase C Homolog

1992 • 322 citations

The carboxy-terminal segment of the yeast α-factor receptor is a regulatory domain

1988 • 317 citations

MKK1 and MKK2, Which Encode Saccharomyces cerevisiae Mitogen-Activated Protein Kinase-Kinase Homologs, Function in the Pathway Mediated by Protein Kinase C

1993 • 306 citations

Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies.

1992 • 300 citations

A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae

1989 • 298 citations

Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-I cDNA

1988 • 285 citations

The proliferation of MAP kinase signaling pathways in yeast

1995 • 243 citations

Photoreceptor Deactivation and Retinal Degeneration Mediated by a Photoreceptor-Specific Protein Kinase C

1991 • 240 citations

The osmotic integrity of the yeast cell requires a functional PKC1 gene product.

1992 • 229 citations

The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts.

1993 • 222 citations

Physiological characterization of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones.

1982 • 216 citations

The C-terminus of the S. cerevisiae α-pheromone receptor mediates an adaptive response to pheromone

1988 • 214 citations

Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation.

1991 • 201 citations

Recovery of S. cerevisiae a cells from G1 arrest by α factor pheromone requires endopeptidase action

1979 • 193 citations

MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C.

1993 • 187 citations

A Drosophila mutant defective in extracellular calcium-dependent photoreceptor deactivation and rapid desensitization

1991 • 186 citations

Dominant mutations in a gene encoding a putative protein kinase (BCK1) bypass the requirement for a Saccharomyces cerevisiae protein kinase C homolog.

1992 • 181 citations

Thrombin and Phorbol Esters Cause the Selective Phosphorylation of a G Protein Other Than Gi in Human Platelets

1989 • 181 citations

Protein kinase C is required for light adaptation in Drosophila photoreceptors

1993 • 154 citations

Saccharomyces cerevisiae PKC1 encodes a protein kinase C (PKC) homolog with a substrate specificity similar to that of mammalian PKC

1994 • 147 citations

Constitutive mutants in the yeast pheromone response: Ordered function of the gene products

1989 • 143 citations

Expression of protein kinase C genes in hemopoietic cells is cell-type- and B cell-differentiation stage specific.

1991 • 142 citations

Structural and functional diversities of a family of signal transducing protein kinases, protein kinase C family; two distinct classes of PKC, conventional cPKC and novel nPKC

1991 • 134 citations

A Yeast Mitogen-Activated Protein Kinase Homolog (Mpk1p) Mediates Signalling by Protein Kinase C

1993 • 126 citations

Mutations in a gene encoding the alpha subunit of a Saccharomyces cerevisiae G protein indicate a role in mating pheromone signaling.

1988 • 121 citations

A mutant protein kinase C that can transform fibroblasts

1989 • 119 citations

Beta and gamma subunits of a yeast guanine nucleotide-binding protein are not essential for membrane association of the alpha subunit but are required for receptor coupling.

1990 • 118 citations

G Protein‐Coupled Receptor Kinases

1994 • 104 citations

Overexpression of protein kinase C epsilon is oncogenic in rat colonic epithelial cells.

1996 • 99 citations

Yeast cells recover from mating pheromone alpha factor-induced division arrest by desensitization in the absence of alpha factor destruction.

1984 • 98 citations

Dissecting the protein kinase C/MAP kinase signalling pathway of Saccharomyces cerevisiae.

1994 • 97 citations

Mouse protein kinase C-.delta., the major isoform expressed in mouse hemopoietic cells: sequence of the cDNA, expression patterns, and characterization of the protein

1991 • 85 citations

SGV1 encodes a CDC28/cdc2-related kinase required for a Gα subunit-mediated adaptive response to pheromone in S. cerevisiae

1991 • 79 citations

Protein kinase C in Saccharomyces cerevisiae: comparison with the mammalian enzyme.

1990 • 76 citations

The protein kinase C-related PKC-L(eta) gene product is localized in the cell nucleus.

1992 • 74 citations

Failure of wild-type or a mutant form of protein kinase C-α to transform fibroblasts

1991 • 68 citations

Identification of Two Essential Phosphorylated Threonine Residues In the Catalytic Domain of Mekk1

1997 • 67 citations

Selective effects of activation of protein kinase C isozymes on cyclic AMP accumulation.

1991 • 66 citations

GPA1Val-50 mutation in the mating-factor signaling pathway in Saccharomyces cerevisiae.

1989 • 61 citations

Signal transduction and growth control in yeast

1995 • 55 citations

Arresting G-protein coupled receptor activity

1993 • 53 citations

Phospholipid and Ca⁺⁺ dependency of phorbol ester receptors

1985 • 53 citations

The η Isoform of Protein Kinase C Is Localized on Rough Endoplasmic Reticulum

1994 • 50 citations

G protein mutations that alter the pheromone response in Saccharomyces cerevisiae.

1990 • 46 citations

Identification of multiple, novel, protein kinase C‐related gene products

1994 • 45 citations

Molecular and biochemical characterization of a recombinant human PKC-δ family member

1993 • 39 citations

The Mating-Specific G_α Protein of Saccharomyces cerevisiae Downregulates the Mating Signal by a Mechanism That Is Dependent on Pheromone and Independent of G_βγ Sequestration

1996 • 39 citations

Suppressors of a gpa1 mutation cause sterility in Saccharomyces cerevisiae.

1988 • 13 citations

Molecular Biology for Nonmolecular Biologists

1990 • 4 citations