Epigenetic and replacement roles of histone variant H3.3 in reproduction and development

Translating the Histone Code

2001 • 9,488 citations

The Role of Chromatin during Transcription

2007 • 3,396 citations

A monomeric red fluorescent protein

2002 • 2,344 citations

Histone H3.1 and H3.3 Complexes Mediate Nucleosome Assembly Pathways Dependent or Independent of DNA Synthesis

2004 • 1,245 citations

The WD repeat: a common architecture for diverse functions

1999 • 1,225 citations

The Histone Variant H3.3 Marks Active Chromatin by Replication-Independent Nucleosome Assembly

2002 • 1,088 citations

From Silencing to Gene Expression

2004 • 681 citations

Purification and characterization of CAF-I, a human cell factor required for chromatin assembly during DNA replication in vitro

1989 • 667 citations

Formation of MacroH2A-Containing Senescence-Associated Heterochromatin Foci and Senescence Driven by ASF1a and HIRA

2005 • 651 citations

Meiotic sex chromosome inactivation

2007 • 651 citations

Phylogenomics of the nucleosome

2003 • 578 citations

Nucleosome stability mediated by histone variants H3.3 and H2A.Z

2007 • 518 citations

Histone H3.3 is enriched in covalent modifications associated with active chromatin

2004 • 498 citations

Genome-scale profiling of histone H3.3 replacement patterns

2005 • 493 citations

Regulation of Replication Fork Progression Through Histone Supply and Demand

2007 • 454 citations

Nucleosome destabilization in the epigenetic regulation of gene expression

2007 • 433 citations

Histone H3 variants and their potential role in indexing mammalian genomes: The “H3 barcode hypothesis”

2006 • 415 citations

HIRA Is Critical for a Nucleosome Assembly Pathway Independent of DNA Synthesis

2002 • 406 citations

Characterization of the CHD family of proteins

1997 • 389 citations

PTMs on H3 Variants before Chromatin Assembly Potentiate Their Final Epigenetic State

2006 • 387 citations

The Chd family of chromatin remodelers

2007 • 387 citations

Molecular Dissection of Formation of Senescence-Associated Heterochromatin Foci

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Evidence for Eviction and Rapid Deposition of Histones upon Transcriptional Elongation by RNA Polymerase II

2004 • 357 citations

Histone chaperones: an escort network regulating histone traffic

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The histone H3.3 chaperone HIRA is essential for chromatin assembly in the male pronucleus

2005 • 328 citations

Asymmetry in Histone H3 variants and lysine methylation between paternal and maternal chromatin of the early mouse zygote

2005 • 324 citations

Histone H3 variants specify modes of chromatin assembly

2002 • 320 citations

Transcriptional activation triggers deposition and removal of the histone variant H3.3

2005 • 316 citations

Expression Patterns and Post-translational Modifications Associated with Mammalian Histone H3 Variants

2005 • 314 citations

Epigenetic memory of an active gene state depends on histone H3.3 incorporation into chromatin in the absence of transcription

2007 • 305 citations

Histone variants, nucleosome assembly and epigenetic inheritance

2004 • 303 citations

Histone variants meet their match

2005 • 294 citations

Sperm decondensation in Xenopus egg cytoplasm is mediated by nucleoplasmin

1991 • 281 citations

Structure and function of the histone chaperone CIA/ASF1 complexed with histones H3 and H4

2007 • 280 citations

ASSEMBLY OF VARIANT HISTONES INTO CHROMATIN

2005 • 278 citations

High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo: roles in promoter proximal pausing and transcription elongation

2000 • 273 citations

Histone Replacement Marks the Boundaries of cis-Regulatory Domains

2007 • 270 citations

Genomic and functional evolution of the Drosophila melanogaster sperm proteome

2006 • 269 citations

Distinct activities of CHD1 and ACF in ATP-dependent chromatin assembly

2005 • 262 citations

The role of histones in chromatin remodelling during mammalian spermiogenesis

2004 • 248 citations

Distinct Dynamics of HISTONE3 Variants between the Two Fertilization Products in Plants

2007 • 246 citations

Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryos

2006 • 237 citations

CHD1 Motor Protein Is Required for Deposition of Histone Variant H3.3 into Chromatin in Vivo

2007 • 236 citations

Nucleoplasmin remodels sperm chromatin in Xenopus egg extracts

1992 • 235 citations

New Histone Incorporation Marks Sites of UV Repair in Human Cells

2006 • 230 citations

Spt5 and Spt6 are associated with active transcription and have characteristics of general elongation factors in D. melanogaster

2000 • 221 citations

Patterns of histone variant synthesis can distinguish go from G1 cells

1982 • 217 citations

Chromosome-wide nucleosome replacement and H3.3 incorporation during mammalian meiotic sex chromosome inactivation

2007 • 214 citations

Transition from a nucleosome-based to a protamine-based chromatin configuration during spermiogenesis inDrosophila

2007 • 212 citations

Differential histone modifications mark mouse imprinting control regions during spermatogenesis

2007 • 209 citations

A walk though vertebrate and invertebrate protamines

2003 • 197 citations

Analysis of the histone H3 gene family in Arabidopsis and identification of the male‐gamete‐specific variant AtMGH3

2005 • 195 citations

Histone chaperones: 30 years from isolation to elucidation of the mechanisms of nucleosome assembly and disassembly

2007 • 195 citations

Sperm chromatin proteomics identifies evolutionarily conserved fertility factors

2006 • 194 citations

Serine 31 phosphorylation of histone variant H3.3 is specific to regions bordering centromeres in metaphase chromosomes

2005 • 179 citations

CHD proteins: a diverse family with strong tiesThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.

2007 • 177 citations

Marking histone H3 variants: How, when and why?

2007 • 173 citations

Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging

2007 • 170 citations

Variant histone H3.3 is deposited at sites of nucleosomal displacement throughout transcribed genes while active histone modifications show a promoter-proximal bias

2005 • 169 citations

Transcriptional Activators Are Dispensable for Transcription in the Absence of Spt6-Mediated Chromatin Reassembly of Promoter Regions

2006 • 167 citations

Variant histone H3.3 marks promoters of transcriptionally active genes during mammalian cell division

2005 • 162 citations

Replacement by Drosophila melanogaster Protamines and Mst77F of Histones during Chromatin Condensation in Late Spermatids and Role of Sesame in the Removal of These Proteins from the Male Pronucleus

2005 • 158 citations

Chromatin assembly: a basic recipe with various flavours

2006 • 150 citations

Structural basis for the interaction of Asf1 with histone H3 and its functional implications

2005 • 142 citations

Structure, dynamics, and evolution of centromeric nucleosomes

2007 • 141 citations

Germline histone dynamics and epigenetics

2007 • 139 citations

Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer

2005 • 135 citations

Hir1p and Hir2p Function as Transcriptional Corepressors To Regulate Histone Gene Transcription in the Saccharomyces cerevisiae Cell Cycle

1997 • 134 citations

Targeted Mutagenesis of the Hira Gene Results in Gastrulation Defects and Patterning Abnormalities of Mesoendodermal Derivatives Prior to Early Embryonic Lethality

2002 • 134 citations

ASF1 Binds to a Heterodimer of Histones H3 and H4: A Two-Step Mechanism for the Assembly of the H3−H4 Heterotetramer on DNA

2005 • 128 citations

The Essential Role of Drosophila HIRA for De Novo Assembly of Paternal Chromatin at Fertilization

2007 • 126 citations

A human homolog of the S.cerevisiae HIR1 and HIR2 transcriptional repressors cloned from the DiGeorge syndrome critical region

1995 • 121 citations

The histone chaperone Asf1 at the crossroads of chromatin and DNA checkpoint pathways

2006 • 115 citations

Histone H3.3 Variant Dynamics in the Germline of Caenorhabditis elegans

2006 • 107 citations

A retroviral Gene Trap Insertion into the Histone 3.3A Gene Causes Partial Neonatal Lethality, Stunted Growth, Neuromuscular Deficits and Male Sub-fertility in Transgenic Mice

1999 • 107 citations

Protamine–histone replacement and DNA replication in the male mouse pronucleus

1990 • 106 citations

Core Histones and HIRIP3, a Novel Histone-Binding Protein, Directly Interact with WD Repeat Protein HIRA

1998 • 105 citations

Testis-Specific Expression of a Novel Human H3 Histone Gene

1996 • 105 citations

Changes in nucleosomal core histone variants during chicken development and maturation

1983 • 94 citations

Drosophila GAGA factor directs histone H3.3 replacement that prevents the heterochromatin spreading

2007 • 92 citations

Assembly and Disassembly of Nucleosome Core Particles Containing Histone Variants by Human Nucleosome Assembly Protein I

2005 • 83 citations

Quantitative and qualitative changes in histone gene expression during early mouse embryo development.

1985 • 82 citations

Transcription through chromatin: understanding a complex FACT

2003 • 79 citations

Distribution of histone H3.3 in hematopoietic cell lineages

2006 • 76 citations

Regulation of nucleosomal core histone variant levels in differentiating murine erythroleukemia cells

1984 • 76 citations

The Maternal Effect Mutation sésame Affects the Formation of the Male Pronucleus in Drosophila melanogaster

2000 • 74 citations

Deposition and Function of Histone H3 Variants in Tetrahymena thermophila

2006 • 72 citations

Differential expression of human replacement and cell cycle dependent H3 histone genes

2003 • 69 citations

HP1 Proteins Are Essential for a Dynamic Nuclear Response That Rescues the Function of Perturbed Heterochromatin in Primary Human Cells

2006 • 63 citations

Structure of the yeast histone H3-ASF1 interaction: implications for chaperone mechanism, species-specific interactions, and epigenetics

2006 • 62 citations

2 Transforming Sperm Nuclei into Male Pronuclei in Vivo and in Vitro

1996 • 62 citations

How to Pack the Genome for a Safe Trip

2005 • 60 citations

Structure and expression of histone H3.3 genes inDrosophila melanogasterandDrosophila hydei

1995 • 58 citations

Changes in the Levels of Three Different Classes of Histone mRNA During Murine Erythroleukemia Cell Differentiation

1985 • 58 citations

Expression of metazoan replication-dependent histone genes

2005 • 57 citations

Germline X Chromosomes Exhibit Contrasting Patterns of Histone H3 Methylation in Caenorhabditis elegans

2002 • 55 citations

Induction of H3.3 replacement histone mRNAs during the precommitment period of murine erythroleukemia cell differentiation

1993 • 53 citations

Meiotic sex chromosome inactivation

2010 • 52 citations

The Drosophila maternal gene sésame is required for sperm chromatin remodeling at fertilization

2001 • 50 citations

Remodeling of sperm chromatin following fertilization: Nucleosome repeat length and histone variant transitions in the absence of DNA synthesis

1984 • 49 citations

Changes in core histone variant composition in differentiating neurons: the roles of differential turnover and synthesis rates.

1995 • 49 citations

Structure of the Histone Chaperone Asf1 Bound to the Histone H3 C-Terminal Helix and Functional Insights

2007 • 47 citations

The histone chaperone Asf1 is dispensable for direct de novo histone deposition in Xenopus egg extracts

2007 • 39 citations

Modulation of histone H3 variant synthesis during the myoblast-myotube transition of chicken myogenesis

1987 • 36 citations

Identification and characterization of the Drosophila histone H4 replacement gene

1996 • 36 citations

The localization of histone H3.3 in germ line chromatin of Drosophila males as established with a histone H3.3-specific antiserum

1997 • 35 citations

The characterization of amphibian nucleoplasmins yields new insight into their role in sperm chromatin remodeling

2006 • 33 citations

From silencing to gene expression: Real-time analysis in single cells

2004 • 33 citations

Changes in the proportions of histone H1° subtypes in brain cortical neurons

1987 • 27 citations

How many remodelers does it take to make a brain? Diverse and cooperative roles of ATP-dependent chromatin-remodeling complexes in developmentThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.

2007 • 27 citations

Different Roles of N-terminal and C-terminal Halves of HIRA in Transcription Regulation of Cell Cycle-related Genes That Contribute to Control of Vertebrate Cell Growth

2005 • 25 citations

Specific alterations in the pattern of histone-3 synthesis during conversion of human leukemic cells to terminally differentiated cells in culture

1984 • 25 citations

Phosphorylation of the histone H3.3 variant in mitosis and meiosis of the urochordate Oikopleura dioica

2007 • 24 citations

Dynamic Regulation of Histone Modifications in Xenopus Oocytes through Histone Exchange

2006 • 22 citations

Organization and expression of the developmentally regulated H1(o) histone gene in vertebrates.

1996 • 20 citations

Transcriptional Activators Are Dispensable for Transcription in the Absence of Spt6-Mediated Chromatin Reassembly of Promoter Regions

2006 • 12 citations

Poly A-containing histone H4 mRNA variant (H4-v.1): Isolation and sequence determination from bovine adrenal medulla

1998 • 11 citations

Structure and function of the histone chaperone CIA/ASF1 complexed with histones H3 and H4

2008 • 11 citations

Characterization, localization and possible anti‐inflammatory function of rat histone H4 mRNA variants

2006 • 7 citations

Deleted Work

1955 • 0 citations