Nucleosome destabilization in the epigenetic regulation of gene expression

Crystal structure of the nucleosome core particle at 2.8 Å resolution

1997 • 8,906 citations

The language of covalent histone modifications

2000 • 8,260 citations

High-Resolution Profiling of Histone Methylations in the Human Genome

2007 • 6,479 citations

A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells

2006 • 5,132 citations

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

2007 • 3,994 citations

The Genetics and Biology of Drosophila

1978 • 3,910 citations

The Role of Chromatin during Transcription

2007 • 3,396 citations

Chromosomal Subunits in Active Genes Have an Altered Conformation

1976 • 1,842 citations

New DNA sequence rules for high affinity binding to histone octamer and sequence-directed nucleosome positioning

1998 • 1,703 citations

A genomic code for nucleosome positioning

2006 • 1,478 citations

The Genetics and Biology of Drosophila

1976 • 1,427 citations

Polycomb silencers control cell fate, development and cancer

2006 • 1,283 citations

ATP-Driven Exchange of Histone H2AZ Variant Catalyzed by SWR1 Chromatin Remodeling Complex

2003 • 1,264 citations

Histone H3.1 and H3.3 Complexes Mediate Nucleosome Assembly Pathways Dependent or Independent of DNA Synthesis

2004 • 1,245 citations

Cellular Memory and the Histone Code

2002 • 1,137 citations

Genome-Scale Identification of Nucleosome Positions in S. cerevisiae

2005 • 1,113 citations

Methylation of Lysine 4 on Histone H3: Intricacy of Writing and Reading a Single Epigenetic Mark

2007 • 1,104 citations

Controlling the double helix

2003 • 1,102 citations

The Histone Variant H3.3 Marks Active Chromatin by Replication-Independent Nucleosome Assembly

2002 • 1,088 citations

Epigenetic Codes for Heterochromatin Formation and Silencing

2002 • 858 citations

Polycomb silencing mechanisms and the management of genomic programmes

2006 • 847 citations

FACT Facilitates Transcription-Dependent Nucleosome Alteration

2003 • 845 citations

The Glucocorticoid Receptor: Rapid Exchange with Regulatory Sites in Living Cells

2000 • 791 citations

The Paf1 Complex Is Required for Histone H3 Methylation by COMPASS and Dot1p: Linking Transcriptional Elongation to Histone Methylation

2003 • 717 citations

DNA bending and its relation to nucleosome positioning

1985 • 702 citations

Translational and rotational settings of H2A.Z nucleosomes across the Saccharomyces cerevisiae genome

2007 • 690 citations

Kinetics of Core Histones in Living Human Cells

2001 • 669 citations

Purification and characterization of CAF-I, a human cell factor required for chromatin assembly during DNA replication in vitro

1989 • 667 citations

Acetylation by Tip60 Is Required for Selective Histone Variant Exchange at DNA Lesions

2004 • 657 citations

Conserved Histone Variant H2A.Z Protects Euchromatin from the Ectopic Spread of Silent Heterochromatin

2003 • 619 citations

Maintenance of Stable Heterochromatin Domains by Dynamic HP1 Binding

2003 • 608 citations

Recruitment of the INO80 Complex by H2A Phosphorylation Links ATP-Dependent Chromatin Remodeling with DNA Double-Strand Break Repair

2004 • 602 citations

Epigenetic Gene Regulation in the Bacterial World

2006 • 598 citations

Genome-wide analysis of Polycomb targets in Drosophila melanogaster

2006 • 591 citations

INO80 and γ-H2AX Interaction Links ATP-Dependent Chromatin Remodeling to DNA Damage Repair

2004 • 564 citations

Dynamics of Replication-Independent Histone Turnover in Budding Yeast

2007 • 560 citations

NAD+-Dependent Modulation of Chromatin Structure and Transcription by Nucleosome Binding Properties of PARP-1

2004 • 532 citations

Genome-Wide Dynamics of Htz1, a Histone H2A Variant that Poises Repressed/Basal Promoters for Activation through Histone Loss

2005 • 530 citations

Nucleosome stability mediated by histone variants H3.3 and H2A.Z

2007 • 518 citations

Crystal structure of a nucleosome core particle containing the variant histone H2A.Z.

2000 • 513 citations

Histone H3.3 is enriched in covalent modifications associated with active chromatin

2004 • 498 citations

Genome-scale profiling of histone H3.3 replacement patterns

2005 • 493 citations

Polycomb/Trithorax response elements and epigenetic memory of cell identity

2006 • 450 citations

Role of linker histone in chromatin structure and function: H1 stoichiometry and nucleosome repeat length

2006 • 434 citations

Structural Basis for the Histone Chaperone Activity of Asf1

2006 • 432 citations

Rtt109 Acetylates Histone H3 Lysine 56 and Functions in DNA Replication

2007 • 421 citations

Nucleosomes Unfold Completely at a Transcriptionally Active Promoter

2003 • 402 citations

Histones Are First Hyperacetylated and Then Lose Contact with the Activated PHO5 Promoter

2003 • 397 citations

Histone trimethylation and the maintenance of transcriptional ONand OFF states by trxG and PcG proteins

2006 • 397 citations

Acetylation in Histone H3 Globular Domain Regulates Gene Expression in Yeast

2005 • 393 citations

Regulated nucleosome mobility and the histone code

2004 • 390 citations

H2A.Z-Mediated Localization of Genes at the Nuclear Periphery Confers Epigenetic Memory of Previous Transcriptional State

2007 • 382 citations

Molecular Dissection of Formation of Senescence-Associated Heterochromatin Foci

2007 • 378 citations

On the use of the word ‘epigenetic’

2007 • 331 citations

Histone chaperones, a supporting role in the limelight

2003 • 319 citations

Genome-Wide Replication-Independent Histone H3 Exchange Occurs Predominantly at Promoters and Implicates H3 K56 Acetylation and Asf1

2007 • 317 citations

Genome-scale mapping of DNase I sensitivity in vivo using tiling DNA microarrays

2006 • 316 citations

Transcriptional activation triggers deposition and removal of the histone variant H3.3

2005 • 316 citations

Expression Patterns and Post-translational Modifications Associated with Mammalian Histone H3 Variants

2005 • 314 citations

Histone variants, nucleosome assembly and epigenetic inheritance

2004 • 303 citations

PCNA connects DNA replication to epigenetic inheritance in yeast

2000 • 302 citations

H2A.Z Alters the Nucleosome Surface to Promote HP1α-Mediated Chromatin Fiber Folding

2004 • 300 citations

Chromatin Disassembly Mediated by the Histone Chaperone Asf1 Is Essential for Transcriptional Activation of the Yeast PHO5 and PHO8 Genes

2004 • 293 citations

Modulation of Heterochromatin Protein 1 Dynamics in Primary Mammalian Cells

2003 • 289 citations

Spreading of silent chromatin: inaction at a distance

2006 • 286 citations

Structure and function of the histone chaperone CIA/ASF1 complexed with histones H3 and H4

2007 • 280 citations

ASSEMBLY OF VARIANT HISTONES INTO CHROMATIN

2005 • 278 citations

The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth

2007 • 277 citations

Histone Replacement Marks the Boundaries of cis-Regulatory Domains

2007 • 270 citations

The histone methyltransferases Trithorax and Ash1 prevent transcriptional silencing by Polycomb group proteins

2004 • 267 citations

Chromatin remodeling by ISW2 and SWI/SNF requires DNA translocation inside the nucleosome

2006 • 257 citations

Removal of Promoter Nucleosomes by Disassembly Rather Than Sliding In Vivo

2004 • 255 citations

Histone chaperone Asf1 is required for histone H3 lysine 56 acetylation, a modification associated with S phase in mitosis and meiosis

2006 • 248 citations

A model for chromatin based upon two symmetrically paired half-nucleosomes

1976 • 245 citations

Mass spectrometry analysis of Arabidopsis histone H3 reveals distinct combinations of post-translational modifications

2004 • 239 citations

Rapid Periodic Binding and Displacement of the Glucocorticoid Receptor during Chromatin Remodeling

2004 • 234 citations

ATP-Dependent Chromatin Remodeling

2004 • 225 citations

A New Fluorescence Resonance Energy Transfer Approach Demonstrates That the Histone Variant H2AZ Stabilizes the Histone Octamer within the Nucleosome

2004 • 217 citations

Chromatin remodeling by nucleosome disassembly in vitro

2006 • 208 citations

Rtt109 Is Required for Proper H3K56 Acetylation

2006 • 207 citations

Hotspots of transcription factor colocalization in the genome of Drosophila melanogaster

2006 • 204 citations

The ABC of the BX-C: the bithorax complex explained

2006 • 200 citations

A hyper-dynamic equilibrium between promoter-bound and nucleoplasmic dimers controls NF-κB-dependent gene activity

2006 • 197 citations

Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae Cause Dependence on the Hir/Hpc Pathway: Polymerase Passage May Degrade Chromatin Structure

2002 • 194 citations

PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis

2005 • 194 citations

Polycomb group and trithorax group proteins in Arabidopsis

2007 • 193 citations

Continuous Histone H2B and Transcription-Dependent Histone H3 Exchange in Yeast Cells outside of Replication

2007 • 190 citations

Analysis of Nucleosome Repositioning by Yeast ISWI and Chd1 Chromatin Remodeling Complexes

2006 • 183 citations

CTCF Genomic Binding Sites in Drosophila and the Organisation of the Bithorax Complex

2007 • 179 citations

Variant histone H3.3 is deposited at sites of nucleosomal displacement throughout transcribed genes while active histone modifications show a promoter-proximal bias

2005 • 169 citations

The Drosophila BRM complex facilitates global transcription by RNA polymerase II

2002 • 168 citations

Histone tails modulate nucleosome mobility and regulate ATP-dependent nucleosome sliding by NURF

2001 • 168 citations

Split Decision: What Happens to Nucleosomes during DNA Replication?

2005 • 167 citations

The role of histone H2Av variant replacement and histone H4 acetylation in the establishment of Drosophila heterochromatin

2005 • 166 citations

Variant histone H3.3 marks promoters of transcriptionally active genes during mammalian cell division

2005 • 162 citations

MSI1-like proteins: an escort service for chromatin assembly and remodeling complexes

2005 • 158 citations

Dynamics of histone acetylation in vivo. A function for acetylation turnover?

2002 • 149 citations

Modulation of a Transcription Factor Counteracts Heterochromatic Gene Silencing in Drosophila

2001 • 147 citations

Replication-independent core histone dynamics at transcriptionally active loci in vivo

2005 • 136 citations

Polycomb group protein complexes exchange rapidly in livingDrosophila

2005 • 133 citations

Chaperone-mediated assembly of centromeric chromatinin vitro

2006 • 132 citations

Histone Tails and the H3 αN Helix Regulate Nucleosome Mobility and Stability

2007 • 131 citations

Antagonistic forces that position nucleosomes in vivo

2006 • 129 citations

Probing long-distance regulatory interactions in the Drosophila melanogaster bithorax complex using Dam identification

2006 • 123 citations

Global patterns of histone modifications

2007 • 117 citations

Rules and regulation in the primary structure of chromatin

2007 • 114 citations

Maintenance of gene expression patterns

2005 • 113 citations

14 Pairing-sensitive silencing, polycomb group response elements, and transposon homing in Drosophila

2002 • 111 citations

Histone H3.3 Variant Dynamics in the Germline of Caenorhabditis elegans

2006 • 107 citations

Histone chaperone ASF1 cooperates with the Brahma chromatin-remodelling machinery

2002 • 107 citations

Patterning chromatin: form and function for H2A.Z variant nucleosomes

2006 • 102 citations

Sequence analysis of acetylation and methylation in two histone H3 variants of alfalfa.

1990 • 96 citations

Drosophila GAGA factor directs histone H3.3 replacement that prevents the heterochromatin spreading

2007 • 92 citations

Transcription-induced Chromatin Remodeling at the c-myc Gene Involves the Local Exchange of Histone H2A.Z

2005 • 90 citations

Histones Are Incorporated in trans during Reassembly of the Yeast PHO5 Promoter

2005 • 89 citations

The Function and Regulation of the JARID1 Family of Histone H3 Lysine 4 Demethylases: the Myc Connection

2007 • 89 citations

Assembly and Disassembly of Nucleosome Core Particles Containing Histone Variants by Human Nucleosome Assembly Protein I

2005 • 83 citations

Transcription through chromatin by RNA polymerase II: Histone displacement and exchange

2007 • 82 citations

Distribution of histone H3.3 in hematopoietic cell lineages

2006 • 76 citations

Structure of the yeast histone H3-ASF1 interaction: implications for chaperone mechanism, species-specific interactions, and epigenetics

2006 • 62 citations

HMG-D and histone H1 alter the local accessibility of nucleosomal DNA

2003 • 43 citations

Molecular analysis of the responder satellite DNA in Drosophila melanogaster: DNA bending, nucleosome structure, and Rsp-binding proteins.

1991 • 31 citations