The role of hepatic lipase in lipoprotein metabolism and atherosclerosis

PLASMA-HIGH-DENSITY-LIPOPROTEIN CONCENTRATION AND DEVELOPMENT OF ISCHÆMIC HEART-DISEASE

1975 • 2,653 citations

Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor

1996 • 2,293 citations

High-Density Lipoprotein — The Clinical Implications of Recent Studies

1989 • 1,565 citations

Postprandial lipoprotein metabolism in normolipidemic men with and without coronary artery disease.

1991 • 538 citations

Meeting Highlights

1996 • 497 citations

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants.

1998 • 454 citations

Isolated Low HDL Cholesterol As a Risk Factor for Coronary Heart Disease Mortality

1997 • 393 citations

High density lipoprotein2. Relationship of the plasma levels of this lipoprotein species to its composition, to the magnitude of postprandial lipemia, and to the activities of lipoprotein lipase and hepatic lipase.

1987 • 383 citations

Lipoprotein abnormalities associated with a familial deficiency of hepatic lipase

1982 • 327 citations

Lipoprotein Metabolism during Acute Inhibition of Hepatic Triglyceride Lipase in the Cynomolgus Monkey

1982 • 259 citations

On the metabolic function of heparin-releasable liver lipase

1980 • 250 citations

A hepatic lipase ( LIPC ) allele associated with high plasma concentrations of high density lipoprotein cholesterol

1997 • 250 citations

Effect of hepatic lipase on LDL in normal men and those with coronary artery disease.

1993 • 248 citations

Triglyceride lpases and atherosclerosis

1995 • 243 citations

Hepatic lipase deficiency. Clinical, biochemical, and molecular genetic characteristics.

1993 • 239 citations

Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins.

1994 • 236 citations

Hepatic endothelial lipase antiserum influences rat plasma low and high density lipoproteins in vivo

1979 • 217 citations

Scavenger Receptor BI (SR-BI) Is Up-regulated in Adrenal Gland in Apolipoprotein A-I and Hepatic Lipase Knock-out Mice as a Response to Depletion of Cholesterol Stores

1996 • 204 citations

Mild Dyslipidemia in Mice following Targeted Inactivation of the Hepatic Lipase Gene

1995 • 199 citations

Low Density Lipoprotein Receptor-related Protein/α2-Macroglobulin Receptor Mediates the Cellular Internalization and Degradation of Thrombospondin

1995 • 181 citations

The mechanism of assimilation of constituents of chylomicrons, very low density lipoproteins and remnants - a new theory

1975 • 176 citations

Atherosclerotic Disease in Marked Hyperalphalipoproteinemia

1995 • 172 citations

Variation at the hepatic lipase and apolipoprotein AI/CIII/AIV loci is a major cause of genetically determined variation in plasma HDL cholesterol levels.

1994 • 167 citations

Common C-to-T Substitution at Position −480 of the Hepatic Lipase Promoter Associated With a Lowered Lipase Activity in Coronary Artery Disease Patients

1997 • 167 citations

Hepatic lipase activity is lower in African American men than in white American men: effects of 5′ flanking polymorphism in the hepatic lipase gene (LIPC)

1998 • 166 citations

Hepatic lipase stimulates the uptake of high density lipoprotein cholesterol by hepatoma cells.

1983 • 155 citations

Heparan Sulfate Proteoglycans Participate in Hepatic Lipaseand Apolipoprotein E-mediated Binding and Uptake of Plasma Lipoproteins, Including High Density Lipoproteins

1997 • 155 citations

Accumulation of intermediate density lipoprotein in plasma after intravenous administration of hepatic triglyceride lipase antibody in rats

1981 • 151 citations

Modification of low density lipoprotein by lipoprotein lipase or hepatic lipase induces enhanced uptake and cholesterol accumulation in cells.

1988 • 148 citations

Human hepatic triglyceride lipase expression reduces high density lipoprotein and aortic cholesterol in cholesterol-fed transgenic mice.

1994 • 143 citations

Role of hepatic lipase in the uptake and processing of chylomicron remnants in rat liver.

1994 • 142 citations

Enhanced binding and uptake of remnant lipoproteins by hepatic lipase-secreting hepatoma cells in culture.

1994 • 138 citations

Activities of lipoprotein lipase and hepatic triglyceride lipase in postheparin plasma of patients with low concentrations of HDL cholesterol.

1993 • 136 citations

Human lipoprotein lipase: the loop covering the catalytic site is essential for interaction with lipid substrates.

1992 • 130 citations

Postheparin plasma lipoprotein and hepatic lipase are determinants of hypo- and hyperalphalipoproteinemia.

1989 • 130 citations

Function of hepatic triglyceride lipase in lipoprotein metabolism

1981 • 129 citations

Overexpression of Human Lecithin Cholesterol Acyltransferase Leads to Hyperalphalipoproteinemia in Transgenic Mice

1995 • 128 citations

The Cellular Internalization and Degradation of Hepatic Lipase Is Mediated by Low Density Lipoprotein Receptor-related Protein and Requires Cell Surface Proteoglycans

1995 • 123 citations

Postheparin plasma triglyceride lipases. Relationships with very low density lipoprotein triglyceride and high density lipoprotein2 cholesterol.

1985 • 122 citations

Deficiency of Hepatic Lipase Activity in Post‐heparin Plasma in Familial Hyper‐α‐Triglyceridemia

1986 • 117 citations

Human Hepatic and Lipoprotein Lipase: The Loop Covering the Catalytic Site Mediates Lipase Substrate Specificity

1995 • 115 citations

Hepatic Lipase Deficiency Increases Plasma Cholesterol but Reduces Susceptibility to Atherosclerosis in Apolipoprotein E-deficient Mice

1997 • 115 citations

The carboxyl-terminal domain of lipoprotein lipase binds to the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP) and mediates binding of normal very low density lipoproteins to LRP.

1994 • 115 citations

Overexpression of Hepatic Lipase in Transgenic Mice Decreases Apolipoprotein B-containing and High Density Lipoproteins

1998 • 109 citations

Hepatic lipase mediates the uptake of chylomicrons and beta-VLDL into cells via the LDL receptor-related protein (LRP)

1996 • 108 citations

Angiographically silent atherosclerosis detected by intravascular ultrasound in patients with familial hypercholesterolemia and familial combined hyperlipidemia: Correlation with high density lipoproteins

1996 • 107 citations

Inhibition of hepatic lipase activity impairs chylomicron remnant-removal in rats

1990 • 100 citations

Hepatic lipase may act as a ligand in the uptake of artificial chylomicron remnant-like particles by isolated rat hepatocytes.

1994 • 89 citations

Relative roles of the LDL receptor, the LDL receptor-like protein, and hepatic lipase in chylomicron remnant removal by the liver.

1996 • 76 citations

Hepatic lipase gene therapy in hepatic lipase-deficient mice. Adenovirus-mediated replacement of a lipolytic enzyme to the vascular endothelium.

1996 • 75 citations

Enrichment of apolipoprotein B-48 in the LDL density class following in vivo inhibition of hepatic lipase

1986 • 72 citations

A dose-response relationship between sex hormone-induced change in hepatic triglyceride lipase and high-density lipoprotein cholesterol in postmenopausal women

1991 • 67 citations

Lipases and lecithin: cholesterol acyltransferase in the control of lipoprotein metabolism

1995 • 66 citations

Metabolism of high density lipoprotein lipids by the rat liver: evidence for participation of hepatic lipase in the uptake of cholesteryl ester.

1992 • 65 citations

Hepatic lipase promotes the uptake of HDL esterified cholesterol by the perfused rat liver: a study using reconstituted HDL particles of defined phospholipid composition.

1994 • 61 citations

Chinese Hamster Ovary Cells Expressing a Cell Surface-anchored Form of Hepatic Lipase

1996 • 58 citations

Genetics and molecular biology of hepatic lipase

1996 • 55 citations

A novel A–>G mutation in intron I of the hepatic lipase gene leads to alternative splicing resulting in enzyme deficiency.

1996 • 53 citations

Selective uptake of cholesteryl esters from low density lipoproteins in vitro and in vivo

1991 • 53 citations

Relationship between Post-Heparin Plasma Lipases, Triglycerides and High Density Lipoproteins in Normal Subjects

1990 • 51 citations

A compound heterozygote for hepatic lipase gene mutations Leu334–>Phe and Thr383–>Met: correlation between hepatic lipase activity and phenotypic expression

1996 • 49 citations

Coexistence of abnormalities of hepatic lipase and lipoprotein lipase in a large family.

1990 • 48 citations

Selective uptake of low-density lipoprotein-associated cholesteryl esters by human fibroblasts, human HepG2 hepatoma cells and J774 macrophages in culture

1995 • 44 citations

Behaviour of phospholipase-modified HDL towards cultured hepatocytes. I. Enhanced transfers of HDL sterols and apoproteins

1990 • 42 citations

Characterization of apoB, E receptor function in the luteinized ovary

1988 • 41 citations

Acceleration of uptake of LDL but not chylomicrons or chylomicron remnants by cells that secrete apoE and hepatic lipase.

1994 • 40 citations

Heterozygous hepatic lipase deficiency, due to two missense mutations R186H and L334F, in the HL gene

1997 • 36 citations

Lipoprotein Lipase Correlates Positively and Hepatic Lipase Inversely With Calcific Atherosclerosis in Homozygous Familial Hypercholesterolemia

1997 • 36 citations

Analysis of Protein Structure-Function in Vivo

1996 • 36 citations

Adenovirus-mediated expression of hepatic lipase in LCAT transgenic mice

1997 • 33 citations

Studies on the function of hepatic lipase in the cat after immunological blockade of the enzyme in vivo

1988 • 20 citations

Analysis of the selective uptake of the cholesteryl ester of human intermediate density lipoproteins by HepG2 cells

1994 • 17 citations

Analysis of the binding and association of human intermediate density lipoproteins to HepG2 cells

1992 • 14 citations

Deleted Work

1955 • 0 citations