A compound heterozygote for hepatic lipase gene mutations Leu334–>Phe and Thr383–>Met: correlation between hepatic lipase activity and phenotypic expression

THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM

1955 • 8,846 citations

[21] Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction

1987 • 5,745 citations

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

1987 • 4,937 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing

1980 • 3,476 citations

Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis

1981 • 1,881 citations

The rapid generation of oligonucleotide-directed mutations at high frequency using phosphorothioate-modified DNA

1985 • 849 citations

Triglycerides Determination after Enzymatic Hydrolysis

1974 • 827 citations

Enzymatische Bestimmung des Gesamt-Cholesterins im Serum

1974 • 747 citations

Apolipoprotein E polymorphism in the Finnish population: gene frequencies and relation to lipoprotein concentrations.

1987 • 410 citations

A primer-guided nucleotide incorporation assay in the genotyping of apolipoprotein E

1990 • 402 citations

Optimal conditions for directly sequencing double-stranded PCR products with Sequenase

1990 • 357 citations

Lipoprotein abnormalities associated with a familial deficiency of hepatic lipase

1982 • 327 citations

Lipoprotein Metabolism during Acute Inhibition of Hepatic Triglyceride Lipase in the Cynomolgus Monkey

1982 • 259 citations

On the metabolic function of heparin-releasable liver lipase

1980 • 250 citations

Hepatic lipase deficiency. Clinical, biochemical, and molecular genetic characteristics.

1993 • 239 citations

Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins.

1994 • 236 citations

Post-Heparin Plasma Lipoprotein Lipase and Hepatic Lipase in Normal Subjects and in Patients with Hypertriglyceridaemia: Correlations to Sex, Age and Various Parameters of Triglyceride Metabolism

1976 • 209 citations

Hepatic lipase induces the formation of pre-beta 1 high density lipoprotein (HDL) from triacylglycerol-rich HDL2. A study comparing liver perfusion to in vitro incubation with lipases

1994 • 207 citations

Purification from human plasma of a heparin-released lipase with activity against triglyceride and phospholipids.

1975 • 204 citations

Mild Dyslipidemia in Mice following Targeted Inactivation of the Hepatic Lipase Gene

1995 • 199 citations

Differential electroimmunoassay of human LpA-I lipoprotein particles on ready-to-use plates

1990 • 188 citations

Human hepatic lipase. Cloned cDNA sequence, restriction fragment length polymorphisms, chromosomal localization, and evolutionary relationships with lipoprotein lipase and pancreatic lipase.

1988 • 184 citations

Lipoprotein metabolism in hepatic lipase deficiency: studies on the turnover of apolipoprotein B and on the effect of hepatic lipase on high density lipoprotein.

1988 • 155 citations

Accumulation of intermediate density lipoprotein in plasma after intravenous administration of hepatic triglyceride lipase antibody in rats

1981 • 151 citations

Human hepatic triglyceride lipase expression reduces high density lipoprotein and aortic cholesterol in cholesterol-fed transgenic mice.

1994 • 143 citations

Role of hepatic lipase in the uptake and processing of chylomicron remnants in rat liver.

1994 • 142 citations

High density lipoprotein subfractions in non-insulin-dependent diabetes mellitus and coronary artery disease.

1995 • 136 citations

Activities of lipoprotein lipase and hepatic triglyceride lipase in postheparin plasma of patients with low concentrations of HDL cholesterol.

1993 • 136 citations

Preparation, characterization, and measurement of hepatic lipase

1986 • 135 citations

Postheparin plasma lipoprotein and hepatic lipase are determinants of hypo- and hyperalphalipoproteinemia.

1989 • 130 citations

Plasma lipoproteins in familial hepatic lipase deficiency.

1990 • 126 citations

Determinants of LDL subfraction distribution and concentrations in young normolipidemic subjects.

1994 • 124 citations

Structure of the human hepatic triglyceride lipase gene

1989 • 122 citations

Deficiency of Hepatic Lipase Activity in Post‐heparin Plasma in Familial Hyper‐α‐Triglyceridemia

1986 • 117 citations

Inhibition of hepatic lipase activity impairs chylomicron remnant-removal in rats

1990 • 100 citations

Hepatic lipase may act as a ligand in the uptake of artificial chylomicron remnant-like particles by isolated rat hepatocytes.

1994 • 89 citations

Reduced HDL2 cholesterol subspecies and elevated postheparin hepatic lipase activity in older men with abdominal obesity and asymptomatic myocardial ischemia.

1992 • 87 citations

Enrichment of apolipoprotein B-48 in the LDL density class following in vivo inhibition of hepatic lipase

1986 • 72 citations

The rabbit as an animal model of hepatic lipase deficiency

1989 • 64 citations

Hepatic lipase promotes the uptake of HDL esterified cholesterol by the perfused rat liver: a study using reconstituted HDL particles of defined phospholipid composition.

1994 • 61 citations

A HEPATIC LIPASE GENE MUTATION ASSOCIATED WITH HERITABLE LIPOLYTIC DEFICIENCY

1991 • 51 citations

Coexistence of abnormalities of hepatic lipase and lipoprotein lipase in a large family.

1990 • 48 citations

The role of hepatic triglyceride lipase in the metabolism of intermediate-density lipoprotein—Postheparin lipolytic activities determined by a sensitive, nonradioisotopic method in hyperlipidemic patients and normals

1986 • 46 citations

Human hepatic lipase mutations and polymorphisms

1992 • 45 citations

Hyperlipidemia accelerates allograft arteriosclerosis (chronic rejection) in the rat.

1994 • 44 citations

Chylomicron-remnant uptake by freshly isolated hepatocytes. Effect of heparin and of hepatic triacylglycerol lipase

1989 • 38 citations

Biotinylation of Oligonucleotides Using a Water Soluble Biotin Ester

1990 • 35 citations

A novel polymorphism of apolipoprotein A-IV is the result of an asparagine to serine substitution at residue 127

1992 • 34 citations

Molecular characterization of human hepatic lipase deficiency. In vitro expression of two naturally occurring mutations.

1994 • 29 citations

[23] Sandwich immunoassay for measurement of human hepatic lipase

1996 • 27 citations

Lipids : current perspectives

1996 • 25 citations

Familial Hepatic Lipase Deficiency

1986 • 22 citations

Studies on the function of hepatic lipase in the cat after immunological blockade of the enzyme in vivo

1988 • 20 citations

Libyan family with hypercholesterolemia and increased high-density lipoprotein cholesterol in plasma

1994 • 10 citations

Deleted Work

1955 • 0 citations